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Management of Clostridioides difficile infection in patients with inflammatory bowel disease

Khanna S

Inflammatory bowel disease (IBD) is a common diarrheal illness with gastrointestinal and extraintestinal manifestations and complications. The most common infectious complication associated with IBD is Clostridioides difficile infection (CDI). Active...
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Factors Related to Outcomes of Fecal Microbiota Transplantation in Patients with Clostridioides difficile Infection

Yoon H, Shim HI, Seol M, Shin CM, Park YS, Kim N, Lee DH

Background/Aims: The aim of this study was to evaluate factors related to outcomes of fecal microbiota transplantation (FMT) in patients with Clostridioides difficile infection (CDI) and viability of frozen stock...
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The diagnostic delay and treatment outcome of Clostridium difficile infection in the patients who underwent rectal surgery

Lee J, Yeom SS, Lee SY, Kim CH, Kim HR, Kim YJ

PURPOSE: The bowel frequency of patients who had undergone rectal resection might be difficult to distinguish from the diarrhea of Clostridium difficile infection (CDI). The change of bowel movement following...
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Determining the risk factors associated with the development of Clostridium difficile infection in patients with hematological diseases

Lee-Tsai Y, Luna-Santiago R, Demichelis-Gómez R, Ponce-de-León A, Ochoa-Hein E, Tamez-Torres KM, Bourlon MT, Bourlon C

BACKGROUND: Clostridium difficile infection (CDI) is a nosocomial condition prevalent in patients with hematological disorders. We aimed to identify the risk factors associated with the development of CDI and assess...
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Laboratory Diagnosis of Clostridium difficile Infection in Korea: The First National Survey

Chung HS, Park JS, Shin BM

In May 2015, we conducted a voluntary online survey on laboratory diagnostic assays for Clostridium difficile infection (CDI) across clinical microbiology laboratories in Korea. Responses were obtained from 66 laboratories,...
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The impact of corticosteroid use on inpatients with inflammatory bowel disease and positive polymerase chain reaction for Clostridium difficile

Lim HW, Schuster I, Rajapakse , Monzur F, Khan S, Sultan K

BACKGROUND/AIMS: Optimal management of inflammatory bowel disease (IBD) with concomitant Clostridium difficile infection (CDI) is controversial, especially when CDI diagnosis is made by polymerase chain reaction (PCR) testing, which may...
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Fecal Microbiota Transplantation: An Update on Clinical Practice

Kim KO, Gluck M

Fecal microbiota transplantation (FMT) is an infusion in the colon, or the delivery through the upper gastrointestinal tract, of stool from a healthy donor to a recipient with a disease...
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Recurrent Clostridium difficile Infection: Risk Factors, Treatment, and Prevention

Song JH, Kim YS

The most common cause of antibiotic-associated diarrhea is Clostridium difficile infection (CDI). Recurrent C. difficile infection (rCDI) often occurs after successful treatment of CDI. Due to the increased incidence and...
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Analyzing Patterns for Stool Culture Requests by Physicians to Improve Quality

Shin H, Kim S

Although international clinical guidelines generally recommend bacterial stool cultures for patients with acute diarrhea, stool cultures are frequently being requested by physicians regardless of the likelihood of a bacterial infection....
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Drug Use Evaluation of Clostridium difficile Infection in Elderly Patients and Risk Factors of Non-improving Group

Noh HJ, Ham JY, Lee JG, Rhie SJ

OBJECTIVE: Clostridium difficile Infection (CDI) is one of the common nosocomial infections. As elderly population increases, the proper treatment has been emphasized. We investigated the risk factors associated with CDI...
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Enteric infections complicating ulcerative colitis

Micic D, Hirsch A, Setia N, Rubin DT

Enteric infections have previously been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD), however, little evidence exists in the etiologic role of specific enteric infections...
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Characteristics and Immunological Roles of Surface Layer Proteins in Clostridium difficile

Mori N, Takahashi

Clostridium difficile is a major causative agent of antibiotic-associated diarrhea and has become the most common pathogen of healthcare-associated infection worldwide. The pathogenesis of C. difficile infection (CDI) is mediated...
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Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki K, Mizuno S, Matsuoka K, Ono K, Sugimoto S, Kiyohara H, Arai M, Nakashima , Takeshita , Saigusa K, Senoh M, Fukuda T, Naganuma M, Kato H, Suda W, Hattori M, Kanai T

Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a...
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Rapid and accurate diagnosis of Clostridium difficile infection by real-time polymerase chain reaction

Song PH, Min JH, Kim YS, Jo SY, Kim EJ, Lee KJ, Lee J, Sung H, Moon JS, Whang DH

BACKGROUND/AIMS: The incidence and severity of Clostridium difficile infection (CDI) have increased worldwide, resulting in a need for rapid and accurate diagnostic methods. METHODS: A retrospective study was conducted to compare...
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Clostridium difficile Infection at Diagnosis and during the Disease Course of Pediatric Inflammatory Bowel Disease

Kim DH, Cho JM, Yang HR

PURPOSE: Clostridium difficile colonization and infection are commonly associated with poor outcomes in patients with pediatric inflammatory bowel disease (PIBD). We aimed to investigate the prevalence of C. difficile colonization...
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Safety and effectiveness of fecal microbiota transplantation: a systematic review

Kim S, Lee Y, Kim SH

Fecal microbiota transplantation is a technique for treating patients suffering from Clostridium difficile infection who do not positively respond to traditional treatment with antibiotics or whose infections have recurred, by...
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A Comparison of Vancomycin and Metronidazole for the Treatment of Clostridium difficile-associated Diarrhea (CDAD) in Medical Intensive Care Unit (MICU)

Cho EA, Lee KA, Kim JS, Kim SH, Son ES

BACKGROUND: Clostridium difficile associated diarrhea (CDAD) is a leading cause of hospital-associated gastrointestinal illness. Risk factors for CDAD include advanced age, long-term admission, antibiotics, proton-pump inhibitor or Hâ‚‚ blocker use...
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Risk of Bacterial Infection from Proton Pump Inhibitor Use

Kim SS, Jo Y, Park SJ, Moon JS, Lee DH, Kim JJ, Lee YC, Ethics and Education Committee of Korean College of Helicobacter and Upper Gastrointestinal Research

Currently, proton pump inhibitors are used in a wide range of patients with gastroesophageal reflux disease, peptic ulcer, and upper gastrointestinal symptoms such as dyspepsia. In addition, the application of...
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Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases

Lee SH, Gong YN, Ryoo E

PURPOSE: The gut microbiota can influence several diseases through immune modulation; however, the exact role of microbes such as Clostridium difficileand the relationship between microbiota colonization and allergic diseases are...
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Fecal Microbiota Transplantation for Refractory and Recurrent Clostridium difficile Infection: A Case Series of Nine Patients

Bang BW, Park JS, Kim HK, Shin YW, Kwon KS, Kwon HY, Baek JH, Lee JS

BACKGROUND/AIMS: Fecal microbiota transplantation (FMT) is a highly effective therapy for refractory and recurrent Clostridium difficile infection (CDI). Despite its excellent efficacy and recent widespread use, FMT has not been...
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