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Validation of soy isoflavone intake and its health effects: a review of the development of exposure biomarkers

Jang HH, Lee YM, Choe JS, Kwon O

BACKGROUND/OBJECTIVES: It is difficult to consistently demonstrate the health effects of soy isoflavones owing to the multitude of factors contributing to their bioavailability. To accurately verify these health effects, dietary...
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Supraeruption as a consideration for implant restoration

Lee BA, Kim B, Kim YT

Purpose: The aim of this study was to compare the prevalence, amount, and rate of supraeruption of the maxillary second molar according to sex, age, and history of periodontitis. Methods: Data...
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The effect of atropine in preventing catheter-related pain and discomfort in patients undergoing transurethral resection due to bladder tumor; prospective randomized, controlled study

Şahiner Y, Yağan , Ekici AA, Ekici M, Demir E

Background: Catheter-related bladder discomfort (CRBD) has been observed in many patients undergoing a urethral catheterization. CRBD may be so severe that the patients require additional analgesics. Muscarinic receptors are involved...
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Clinical interventions and speech outcomes for individuals with submucous cleft palate

Jung SE, Ha S, Koh KS, Oh TS

Background This study aimed to identify the initial diagnostic characteristics and treatment status of children with submucous cleft palate (SMCP) and to examine the relationship between the timing of surgical...
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A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function

Han B, Kim SM, Nam GE, Kim SH, Park SJ, Park YK, Baik HW

Non-alcoholic fatty liver disease (NAFLD) has the potential to develop into hepatic steatosis and progress to terminal liver diseases such as cirrhosis and hepatocellular carcinoma. This human clinical study was...
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Association between fruit and vegetable allergies and pollen-food allergy syndrome in Japanese children: a multicenter cross-sectional case series

Takemura Y, Takaoka Y, Arima T, Masumi H, Yamasaki K, Nagai M, Sugimoto K, Hamada M, Takano T, Doi M, Kawakami T, Kameda M

BACKGROUND: Recently, the prevalence of food allergies during childhood is increasing, with fruits being common allergens. However, data on allergens that cause fruit and vegetable allergies and pollen-food allergy syndrome...
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The Accuracy of the Calculated Dose for a Cardiac Implantable Electronic Device

Sung J, Son J, Park JM, Kim JI, Choi CH

The objective of this study is to monitor the radiation doses delivered to a cardiac implantable electronic device (CIED) by comparing the absorbed doses calculated by a commercial treatment planning...
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Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodefi ciency Mice: Preclinical Study

Quesada MP, García-Bernal D, Pastor D, Estirado A, Blanquer M, García-Hernández AM, Moraleda J, Martínez

BACKGROUND: Mesenchymal stromal cells (MSCs) have potent immunomodulatory and neuroprotective properties, and have been tested in neurodegenerative diseases resulting in meaningful clinical improvements. Regulatory guidelines specify the need to perform...
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PECS II block is associated with lower incidence of chronic pain after breast surgery

De Cassai , Bonanno C, Sandei L, Finozzi F, Carron M, Marchet A

BACKGROUND: Breast cancer is complicated by a high incidence of chronic postoperative pain (25%–60%). Regional anesthesia might play an important role in lowering the incidence of chronic pain; however it...
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Efficacy of a self - applied paint - on whitening gel combined with wrap

Kim SY, Ahn JH, Kim JY, Kim JW, Park SH, Cho KM

PURPOSE: The aim of this clinical study was to evaluate the efficacy and safety of a self - applied paint - on whitening gel combined with wrap to increase the...
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Clinical effects of additional use of erythritol powder air polishing device on non-surgical periodontal treatment in moderate chronic periodontitis

Lee MY, Park EJ, Kwon EY, Kim HJ, Lee JY, Joo JY

PURPOSE: The purpose of this study was to evaluate the clinical effects of erythritol powder air polishing device (EPAP) in addition to scaling and root planing (SRP) in non-surgical periodontal...
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Sagittal Alignment of a Strut Graft Affects Graft Subsidence and Clinical Outcomes of Anterior Cervical Corpectomy and Fusion

Yamauchi K, Fushimi K, Miyamoto K, Hioki A, Shimizu K, Akiyama H

STUDY DESIGN: Retrospective study. PURPOSE: The purpose of this study was to investigate the influence of sagittal alignment of the strut graft on graft subsidence and clinical outcomes after anterior cervical...
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Considerations when calculating the sample size for an inequality test

In J

Calculating the sample size is a vital step during the planning of a study in order to ensure the desired power for detecting clinically meaningful differences. However, estimating the sample...
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Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside

Ahmed MS, Bae YS

Dendritic cells (DCs) are professional antigen presenting cells, and play an important role in the induction of antigen-specific adaptive immunity. However, some DC populations are involved in immune regulation and...
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A Clinical Study of Cutaneous Malignant Tumors in Daegu City and Kyungpook Province for the Recent 20 Years: Comparison of the First (1994~2003) and Second Decade (2004~2013)

Lee K, Kim MJ, Chae SY, Cha HW, Jang YH, Lee WJ, Kim DW, Lee SJ

  • KMID: 2046260
  • Korean J Dermatol.
  • 2015 Aug;53(7):505-514.
BACKGROUND: Although skin cancer incidence has recently increased, there has been little research into the incidence, clinical manifestations, and prognosis of skin cancers in Korea, especially in Daegu City and...
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A Novel Simultaneous Determination of Sarpogrelate and its Active Metabolite (M-1) in Human Plasma, Using Liquid Chromatography-Tandem Mass Spectrometry: Clinical Application

Yang JS, Kim JR, Cho E, Huh W, Ko JW, Lee SY

BACKGROUND: This study describes a novel analytical method for simultaneously determining sarpogrelate and its metabolite (M-1) in human plasma, using liquid chromatography coupled with tandem mass spectrometry, with electrospray ionization...
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Adoptive Cell Therapy of Melanoma with Cytokine-induced Killer Cells

Kim JS, Kim YG, Pyo M, Lee HK, Hong JT, Kim Y, Han SB

Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of
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Optical Coherence Tomography for the Diagnosis and Evaluation of Human Otitis Media

Cho NH, Lee SH, Jung W, Jang JH, Kim J

We report the application of optical coherence tomography (OCT) to the diagnosis and evaluation of otitis media (OM). Whereas conventional diagnostic modalities for OM, including standard and pneumatic otoscopy, are...
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The Present and Future of Clinical Research for Korean Lupus Patients

Kim D, Cho SK, Sung YK

Systemic lupus erythematosus (SLE) is considered to be the prototype of systemic autoimmune disease because it involves the most immune cells and it can affect all organs of the human...
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Medical technology development and globalization: the role of the medical device industry

Lee SS

Modern medical technology aligns with medical device advancement, and new medical devices create the need for new procedure techniques. Unmet needs that physicians experience in clinical practice suggest solutions to...
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