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Vaccine adjuvant materials for cancer immunotherapy and control of infectious disease

Lim YT

Adjuvants can be defined as pharmacological and immunological components that are able to modify and/or enhance antigen-specific immune responses. Based on the interdisciplinary research between immunology and material science/engineering, various...
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Suggested guidelines for vaccination of pigs in Korea

Lee WH, Yoo HS

There is no published guideline for the vaccination to pigs even though several vaccine companies suggested the program based on their products. It is very difficult to standardize the program...
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Clinical vaccine development

Han S

Vaccination is regarded as one of the biggest triumphs in the history of medicine. We are living in the most successful period of vaccine development. The accumulation of multidisciplinary knowledge...
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Comparative evaluation of booster efficacies of BCG, Ag85B, and Ag85B peptides based vaccines to boost BCG induced immunity in BALB/c mice: a pilot study

Husain AA, Warke SR, Kalorey DR, Daginawala HF, Taori GM, Kashyap RS

PURPOSE: In the present study booster efficacies of Ag85 B, Bacillus Calmette-Guerin (BCG), and Ag85B peptides were evaluated using prime boost regimes in BALB/c mice. MATERIALS AND METHODS: Mice were primed...
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Ebola outbreak in Western Africa 2014: what is going on with Ebola virus?

Na W, Park N, Yeom M, Song D

The 2014 outbreak of Ebola virus disease (EVD) in West Africa, caused by Ebola virus (Zaire Ebola virus species), is the largest outbreak of EVD in history. It cause hemorrhagic...
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In silico analysis for identifying potential vaccine candidates against Staphylococcus aureus

Delfani S, Imani Fooladi AA, Mobarez AM, Emaneini M, Amani J, Sedighian

PURPOSE: Staphylococcus aureus is one of the most important causes of nosocomial and community-acquired infections. The increasing incidence of multiple antibiotic-resistant S. aureus strains and the emergence of vancomycin resistant...
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Progress of vaccine and drug development for Ebola preparedness

Choi WY, Hong KJ, Hong JE, Lee WJ

Since the first case of Ebola virus disease (EVD) in Guinea was reported in March 2014 by World Health Organization (WHO), the outbreak has continued through the year and the...
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Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain

Kim RH, Chu JQ, Park JN, Lee SY, Lee YJ, Ko MK, Hwang JH, Lee KN, Kim SM, Tark D, Ko YJ, Lee HS, Seo MG, Park ME, Kim B, Park JH

We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of...
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Preliminary study on the immunogenicity of a newly developed GCC Tdap vaccine and its protection efficacy against Bordetella pertussis in a murine intranasal challenge model

Han SB, Kang KR, Huh DH, Lee HC, Lee SY, Kim JH, Hur JK, Kang JH

PURPOSE: Active reduced dose tetanus-diphtheria-acellular pertussis (Tdap) vaccination for adolescents and adults is necessary because waning immunity after primary diphtheria-tetanus-pertussis vaccination is related to the recent emergence of pertussis. This...
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Systemic antibody response to nano-size calcium phospate biocompatible adjuvant adsorbed HEV-71 killed vaccine

Saeed MI, Omar AR, Hussein MZ, Elkhidir I, Sekawi Z

PURPOSE: Since 1980s, human enterovirus-71 virus (HEV-71) is one of the common infectious disease in Asian Pacific region since late 1970s without effective commercial antiviral or protective vaccine is unavailable...
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Tetanus toxin fragment C fused to flagellin makes a potent mucosal vaccine

Lee SE, Nguyen CT, Kim SY, Thi TN, Rhee JH

PURPOSE: Recombinant subunit vaccines provide safe and targeted protection against microbial infections. However, the protective efficacy of recombinant subunit vaccines tends to be less potent than the whole cell vaccines,...
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Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases

Grunwald T, Ulbert S

Advantages of DNA vaccination against infectious diseases over more classical immunization methods include the possibilities for rapid manufacture, fast adaptation to newly emerging pathogens and high stability at ambient temperatures....
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Oral immunization of mice with recombinant rabies vaccine strain (ERAG3G) induces complete protection

Yang DK, Kim HH, Choi SS, Kim JT, Jeong WH, Song JY

PURPOSE: New rabies vaccine bait for both pets and raccoon dogs residing in Korea is needed to eradicate rabies infection among animals. In this study, we constructed a recombinant rabies...
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Cellular immune response following pre-exposure and postexposure rabies vaccination by intradermal and intramuscular routes

Venkataswamy MM, Madhusudana SN, Sanyal SS, Taj S, Belludi AY, Mani RS, Hazra N

PURPOSE: Immunization against rabies in humans induces protective neutralizing antibodies; however, the induction of type 1 or type 2 cytokine mediated cellular immune responses following rabies vaccination is not understood....
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Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes

Powell BS, Andrianov , Fusco PC

Adjuvants improve the adaptive immune response to a vaccine antigen by modulating innate immunity or facilitating transport and presentation. The selection of an appropriate adjuvant has become vital as new...
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