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An effective method for improving outcomes in patients with a fertilization defect

Yoon HJ, Kim HJ, Bae IH, Chae SJ, Yoon SH, Lee WD, Lim JH

The effect of artificial oocyte activation (AOA) with a calcium ionophore on intracytoplasmic morphologically selected sperm injection (IMSI) was examined in patients with histories of repeated failed implantation attempts. Four...
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Observation of sperm-head vacuoles and sperm morphology under light microscope

Park YS, Park S, Ko DS, Park DW, Seo JT, Yang KM

OBJECTIVE: The presence of sperm-head vacuoles has been suspected to be deleterious to the outcomes of assisted reproductive technology (ART). It is difficult to accurately distinguish morphologically abnormal sperm with...
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Vitrification solution without sucrose for cryopreservation in mouse blastocysts

Joo JK, Lee YJ, Jeong JE, Kim SC, Ko GR, Lee KS

OBJECTIVE: This study was designed to investigate the survival rate of vitrified mouse blastocysts depending on the presence or absence of sucrose in vitrification solution. METHODS: Mouse two-cell embryos were collected...
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Spontaneous ovarian hyperstimulation syndrome following a thawed embryo transfer cycle

Kim MK, Won HJ, Shim SH, Cha DH, Yoon TK

This article reports a case of spontaneous ovarian hyperstimulation syndrome (OHSS) following a thawed embryo transfer cycle. OHSS, a potentially life-threatening condition, is an iatrogenic complication of controlled ovarian stimulation;...
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Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure

Pyun JA, Kim S, Kwack K

OBJECTIVE: The aim of the present study was to examine whether interactions between polymorphisms in the thyroglobulin and ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) genes are associated...
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The role of autophagy in the placenta as a regulator of cell death

Gong JS, Kim GJ

The placenta is a temporary fetomaternal organ capable of supporting fetal growth and development during pregnancy. In particular, abnormal development and dysfunction of the placenta due to cha nges in...
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Empirical medical therapy in idiopathic male infertility: Promise or panacea?

Jung JH, Seo JT

Male factors account for 20%-50% of cases of infertility and in 25% of cases, the etiology of male infertility is unknown. Effective treatments are well-established for hypogonadotropic hypogonadism, male accessory...
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Relationship between reactive oxygen species and autophagy in dormant mouse blastocysts during delayed implantation

Shin H, Choi S, Lim HJ

OBJECTIVE: Under estrogen deficiency, blastocysts cannot initiate implantation and enter dormancy. Dormant blastocysts live longer in utero than normal blastocysts, and autophagy has been suggested as a mechanism underlying the...
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