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Successful Early Clozapine Trial in the Treatment of First-episode Schizophrenia: A Case Report

Kim YJ, No SH, Lee SY

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):168-169.
Clozapine remains the treatment of choice in refractory schizophrenia despite its various requirement to prescribe, such as mandatory blood monitoring program and various metabolic complication. Currently, clozapine is recommended only...
Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases

Min A, Kim D

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):165-167.
We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is...
Simultaneous Screening of 177 Drugs of Abuse in Urine Using Ultra-performance Liquid Chromatography with Tandem Mass Spectrometry in Drug-intoxicated Patients

Lee YW

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):158-164.
OBJECTIVE: The demand for rapid and broad clinical toxicology screening methods to identify drugs of abuse and medicinal drugs is increasing steadily. Liquid chromatography-tandem mass spectrometry (LC-TMS) is increasingly used...
The Influence of Previous Antipsychotic Polypharmacy Versus Monotherapy on the Effectiveness of Antipsychotic after Switching to Paliperidone Extended-release

Lee HW, Na KS, Jung SH, Kang MH, Lee JS, Bae JN, Kim HY, Kim CE

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):152-157.
OBJECTIVE: Although antipsychotic polypharmacy is widely used in the pharmacotherapy of schizophrenia, its effectiveness is controversial. In particular, clinicians tend to avoid switching to monotherapy in patients who have been...
Effects of Antipsychotics on the Inflammatory Response System of Patients with Schizophrenia in Peripheral Blood Mononuclear Cell Cultures

Al-Amin MM, Nasir Uddin MM, Mahmud Reza H

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):144-151.
OBJECTIVE: We investigated the effects of antipsychotics on immune-challenged peripheral blood mononuclear cell (PBMC) cultures. METHODS: Blood samples were collected from twelve patients with first-episode schizophrenia. The PBMCs were separated and...
Comparative Study of Heart Rate Variability in Patients with Schizophrenia, Bipolar Disorder, Post-traumatic Stress Disorder, or Major Depressive Disorder

Moon E, Lee SH, Kim DH, Hwang B

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):137-143.
OBJECTIVE: Heart rate variability (HRV) changes as a function of psychiatric illness. This study aimed to evaluate HRV among patients with various psychiatric disorders. METHODS: The present study recruited patients with...
Long-term Efficacy and Tolerability of Perospirone for Young Help-seeking People at Clinical High Risk: a Preliminary Open Trial

Tsujino N, Nemoto T, Morita K, Katagiri N, Ito S, Mizuno M

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):132-136.
OBJECTIVE: Interest in the "at-risk mental state" (ARMS) for psychosis has increased because early intervention is expected to delay or prevent the onset of schizophrenia. However, the optimum intervention strategy...
Effects of Color Temperature and Brightness on Electroencephalogram Alpha Activity in a Polychromatic Light-emitting Diode

Park JY, Ha RY, Ryu V, Kim E, Jung YC

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):126-131.
OBJECTIVE: It has been reported that working and learning efficiency might be increased through artificially controlling the color temperature and brightness of light. However, the neurological bases of these outcomes...
Transcranial Direct Current Stimulation in Schizophrenia

Agarwal SM, Shivakumar V, Bose A, Subramaniam A, Nawani H, Chhabra H, Kalmady SV, Narayanaswamy JC, Venkatasubramanian G

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):118-125.
Transcranial direct current stimulation (tDCS) is an upcoming treatment modality for patients with schizophrenia. A series of recent observations have demonstrated improvement in clinical status of schizophrenia patients with tDCS....
The Neuroimmunology of Schizophrenia

Smyth AM, Lawrie SM

  • Clin Psychopharmacol Neurosci.
  • 2013 Dec;11(3):107-117.
Schizophrenia (SCZ) is a polygenic, multi-factorial disorder and a definitive understanding of its pathophysiology has been lacking since it was first described more than a century ago. The predominant pharmacological...

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