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Neuroimmune interactions and kidney disease

Hasegawa S, Inoue T, Inagi R

The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a well-studied...
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Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala

Lee S, Kim JH

The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning....
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Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods

Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW

PURPOSE: Loss of cholinergic neurons in the hippocampus is a hallmark of many dementias. Administration of stem cells as a therapeutic intervention for patients is under active investigation, but the...
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Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats

Lee B, Sur B, Cho SG, Yeom M, Shim I, Lee H, Hahm DH

We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these...
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Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex

Jeong DU, Oh JH, Lee JE, Lee J, Cho ZH, Chang JW, Chang WS

PURPOSE: Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer's disease and have been correlated with memory function. Although regions representing glucose hypometabolism in...
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Regulation of Gastric Electrical and Mechanical Activity by Cholinesterases in Mice

Worth AA, Forrest AS, Peri LE, Ward SM, Hennig GW, Sanders KM

  • KMID: 2381252
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):200-216.
  • doi: 10.5056/jnm14120
BACKGROUND/AIMS: Gastric peristalsis begins in the orad corpus and propagates to the pylorus. Directionality of peristalsis depends upon orderly generation and propagation of electrical slow waves and a frequency gradient...
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Vivid Dreaming after Acetyl-L-Carnitine Administration: A Report of Two Cases

Kim H, Yoon DY, Park DY, Han HJ

Acetyl-L-carnitine (ALC), an acetylated form of L-carnitine, is able to influence the activity of cholinergic neurons, cell membrane stabilization and enhancing mitochondrial function. A 52-year-old woman was referred to neurology...
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Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats

Lee B, Sur B, Shim I, Lee H, Hahm DH

We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic...
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Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain

Lee JH, Cheon YH, Woo RS, Song DY, Moon C, Baik TK

Apoptosis inducing factor (AIF) has been proposed to act as a putative reactive oxygen species scavenger in mitochondria. When apoptotic cell death is triggered, AIF translocates to the nucleus, where...
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Novel Pharmacotherapies for Alzheimer's Disease

Han SH

Alzheimer disease (AD) is pathologically characterized by extracellular amyloid deposits composed of beta-amyloid (A beta) peptide, neurofibrillary tangles (NFTs) made up of hyperphosphorylated tau, and deficit of cholinergic neurons in...
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Multiple Eccrine Hidrocystomas Treated with Botulinum Toxinand Fine Needle Electrocoagulation

Choi JH, Sim HS, Jung Y, Seung KH, Lee SK

  • KMID: 2302148
  • Korean J Dermatol.
  • 2007 Oct;45(10):1090-1092.
Multiple eccrine hidrocystomas are benign cysts of eccrine duct and occur mainly in middle aged women with numerous translucent papules on the central face. The treatment of multiple eccrine hidrocystomas...
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Effects of Mosapride Citrate on the Motility of Stomach, Ileum and Colon in Conscious Guinea Pigs

Park CI, Jung IS, Lim JH, Kim NK, Kim H, Park H

  • KMID: 2307471
  • Korean J Neurogastroenterol Motil.
  • 2007 Jun;13(1):53-60.
BACKGROUND/AIMS: Mosapride citrate (Mosapride) is a relatively new selective 5-HT4 receptor agonist. Several studies have reported that mosapride selectively stimulates the upper GI motility, but not lower GI motility. However,...
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Effects of Mirtazapine on Hippocampal Metabolites of Female Patients with Major Depression

Nam YY, Kim CH, Lee SK, Jang DP, Kim JJ, Kim JW, Kim SI, Lee HS

  • KMID: 2286820
  • Korean J Psychopharmacol.
  • 2005 Mar;16(2):146-155.
OBJECTIVE: Recent studies suggested that the neurotrophic effects might be a major therapeutic mechanism of antidepressants. However, these effects have not been confirmed yet in depressed patients. We investigated whether...
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The Improvement of Learning and Memory Ability of Normal Persons by BF-7

Lee SH, Kim YS, Kang YK, Kwon OS, Shin YK, Song JH, Lee MY, Lee KG, Yeo JH, Lee WB, Lee TJ, Kim SS

  • KMID: 1611488
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):307-312.
To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group...
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Choline Acetyltrans ferase Immunoreactivity in the Rat Brainstem

Kim ES, Han DH

  • KMID: 2338343
  • J Korean Geriatr Soc.
  • 2004 Sep;8(3):170-176.
BACKGROUND: Cholinergic neurons in the forebrain of mamals are well elucidated, meanwhile, the distribution of these neurons in the brainstem is not conformed according to investigators. To identify cholinergic neurons...
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Effects of gamma-Aminobutyric Acid on Intrinsic Cholinergic Action in Exocrine Secretion of Isolated, Perfused Rat Pancreas

Park YD, Park HS, Cui ZY, Park HJ

  • KMID: 2071592
  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):169-174.
gamma-Aminobutyric acid (GABA) has been reported to enhance exocrine secretion evoked not only by secretagogues but also by intrinsic neuronal excitation in the pancreas. The pancreas contains cholinergic neurons abundantly...
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Muscarine M2 Receptor-mediated Presynaptic Inhibition of GABAergic Transmission in Rat Meynert Neurons

Jang IS, Akaike N

  • KMID: 1614991
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):63-70.
Cholinergic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) by the activation of muscarine receptors was investigated in mechanically dissociated rat nucleus basalis of the Meynert neurons using the...
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Neurobiology of Age-Associated Memory Impairment

Kim SH, Shin KH

  • KMID: 2064040
  • J Korean Geriatr Psychiatry.
  • 2001 Jun;5(1):17-24.
The diagnostic concept of age-associated memory impairment (AAMI) suggests that clinically recognized memory dysfunction could be a feature of normal aging. Although the memory impairment associated with aging is well...
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The Role of 5-HT Receptors on the Acetylcholine Release from the Rat Striatum

Joo YH, Jung KY, Choi BK

  • KMID: 1607282
  • Korean J Psychopharmacol.
  • 2001 Jun;12(2):140-146.
The aim of this study was to investigate the role of the 5-HT receptors in acetylcholine (ACh) release from the striatum. Slices from the rat striatum and synaptosomes were incubated...
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Synaptic Morphology of the Mouse Striatal Cholinergic Neurons in the Early Postnatal Life

Hann HJ, Lee HL

  • KMID: 2224577
  • Korean J Anat.
  • 1999 Apr;32(2):161-170.
The cholinergic neurons in the striatal complex are the major interneurons that integrate the informations incoming to and outflowing from the striatum. The shape of synapses may change even after...
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