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IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis

Tanaka A

Sclerosing cholangitis (SC) is defined as a condition with progressive stenosis and destruction of the bile ducts due to diffuse inflammation and fibrosis and currently includes three categories: primary sclerosing...
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Hepatobiliary Manifestation of Inflammatory Bowel Disease

Seo KI, Kang SB

The hepatobiliary system is one of the most common sites of extraintestinal manifestation in patients with inflammatory bowel disease (IBD). The progression of IBD can lead to a primary hepatobiliary...
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Detection of Autoantibodies Against Nucleoporin p62 in Sera of Patients With Primary Biliary Cholangitis

Bauer A, Habior A

BACKGROUND: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by specific autoantibodies. We evaluated the prevalence of autoantibodies against nucleoporin p62 (anti-p62) in PBC patients' sera to determine...
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Secondary Sclerosing Cholangitis in Critically Ill Patients

Park N, Paik WH

No abstract available.
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Statin Exposure Is Not Associated with Reduced Prevalence of Colorectal Neoplasia in Patients with Inflammatory Bowel Disease

Shah SC, Glass J, Giustino G, ten Hove J, Castaneda , Torres J, Kumar A, Elman J, Ullman TA, Itzkowitz

BACKGROUND/AIMS: Statins have been postulated to lower the risk of colorectal neoplasia. No studies have examined any possible chemopreventive effect of statins in patients with inflammatory bowel disease (IBD) undergoing...
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Immunoglobulin G4-related sclerosing cholangitis

Goodchild , Pereira SP, Webster G

Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition of which IgG4-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation. In this review, we provide an overview of IgG4-RD, with a...
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A 2-Week Steroid Trial for Differentiating Isolated IgG4-Related Sclerosing Cholangitis from Cholangiocarcinoma

Lee BH, Moon SH, Min KW, Park JW, Lim H, Kim SE, Kang HS, Kim JH

Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is rare disease which is steroid-responsive and often associated with IgG4 related systemic disease such as autoimmune pancreatitis. It is characterized by increased serum IgG4...
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Liver Fluke-Associated Biliary Tract Cancer

Prueksapanich P, Piyachaturawat P, Aumpansub , Ridtitid W, Chaiteerakij R, Rerknimitr R

Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In Western countries,...
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Epidemiology and Risk Factors of Gallbladder Cancer

Kim YS

Gallbladder cancer (GBC)t is highly fatal. Despite recent advances in diagnostic and therapeutic modalities, 5-year survival rate of patients with GBC is less than 5%. Most cases are diagnosed in...
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Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Review of the Phenotype and Associated Specific Features

Palmela C, Peerani F, Castaneda , Torres J, Itzkowitz

Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic disease that is associated with inflammatory bowel disease (IBD) in approximately 70% of cases. Although the pathogenesis is still unknown for...
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Primary Sclerosing Cholangitis in an Elderly Patient: A Diagnostic Challenge

Marco TM, Hiram VV, Lenin PR

Jaundice syndrome is a diagnostic challenge for physicians. It must be diagnosed based on its etiology, which depends on liver function test results, clinical manifestations, and age of presentation, and...
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The role and utility of cholangioscopy for diagnosing indeterminate biliary strictures

Thaker AM, Muthusamy

Biliary strictures are considered indeterminate when evaluation with imaging and standard tissue sampling during endoscopic retrograde cholangiopancreatography (ERCP) are non-diagnostic. Standard tissue sampling techniques include cytologic brushings, with or without...
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IgG4-Related Sclerosing Cholangitis Showing Natural Course of Progression to Decompensated Liver Cirrhosis

Han J, Jun JH, Jung KH, Jeong DH, Park JC, Noh S, Hsing LC, Kim MH

Immunoglobulin G4-related disease (IgG4-RD) is characterized by extensive IgG4-positive plasma cells infiltration resulting in inflammation and fibrosis of the affected organs. Patient with IgG4-RD shows an excellent response to glucocorticoid...
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The Role of Bile Acid Receptors in Chronic Inflammatory Diseases

Park R, Ji JD

With recent developments, biologic therapies has shown superior efficacy for rheumatic diseases compared with preexisting pharmacologic therapies, which are associated with high costs, non-response in certain patient groups, and severe...
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Cholangiocarcinoma: Current Knowledge and New Developments

Blechacz B

Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The...
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Oral Vancomycin Therapy in a Child with Primary Sclerosing Cholangitis and Severe Ulcerative Colitis

Buness C, Lindor KD, Miloh T

Primary sclerosing cholangitis (PSC), a rare progressive liver disease characterized by cholestasis and bile duct fibrosis, has no accepted, effective therapy known to delay or arrest its progression. We report...
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Cholangiocarcinoma Masquerading as IgG4-related Sclerosing Cholangitis

Yi S, Cho DH, Hwang S, Oh K, Kim HJ, Kim J, Kim MH

IgG4-related sclerosing cholangitis (IgG4-SC) represents a rare but clinically challenging differential diagnosis in patients with biliary strictures which can be mistaken for cholangiocarcinoma. We present a case of a 73-year-old...
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Role of random biopsies in surveillance of dysplasia in ulcerative colitis patients with high risk of colorectal cancer

Bopanna S, Roy M, Das P, Dattagupta S, Sreenivas , Mouli VP, Kedia S, Dhingra R, Pradhan R, Kumar NS, Yadav DP, Makharia G, Ahuja V

BACKGROUND/AIMS: Recent data suggest that the incidence of ulcerative colitis (UC) related colorectal cancer (CRC) in India is similar to that of West. The optimum method for surveillance is still...
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Two Cases of Immunoglobulin G4-Related Sclerosing Disease in Submandibular Triangle

Choi JH, Kim CD, Kim EJ, Kim SW

Immunoglobulin G4-related sclerosing disease (IgG4-RD) is histologically a chronic inflammatory disorder characterized by infiltration of lymphoplasmacytes, sclerosis, and an elevated serum level of IgG4 and IgG4 positive plasmocytes. IgG4-RD is...
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Sclerosing Cholangitis: Clinicopathologic Features, Imaging Spectrum, and Systemic Approach to Differential Diagnosis

Seo N, Kim SY, Lee SS, Byun JH, Kim JH, Kim HJ, Lee MG

Sclerosing cholangitis is a spectrum of chronic progressive cholestatic liver disease characterized by inflammation, fibrosis, and stricture of the bile ducts, which can be classified as primary and secondary sclerosing...
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