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Clinical development and trial operations in COVID-19 era

Choe SC

no abstract available.
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Treatment of Hypercholesterolemia in Elderly Patients; From the Viewpoint of Statins

Choe SC, Lee S, Kim CJ

  • KMID: 1742778
  • J Korean Geriatr Soc.
  • 2002 Dec;6(4):253-260.
No abstract available.
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Apolipoprotein E Polymorphism in Patients with Myocardial Infarction

Jeong HS, Kim SK, Lee SC, Bang DW, Shin WY, On YK, Choe SC, Kim CH, Choi TM, Hyun MS, Jeon ES, Kwon YJ

BACKGROUND AND OBJECTIVES: In this study we investigated the association between the polymorphism of apolipoprotein E and the development of myocardial infarction, and assessed whether this polymorphism produces any changes...
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ACE(Angiotensin Converting Enzyme) Gene Polymorphism in Hypertrophic Cadiomyopathy

Choi JH, Kim HS, Lee SC, Choi HS, Choe SC, Oh BH, Lee MM, Park YB, Choi YS, Seo JD

BACKGROUND: In hypertrophic cardiomyopathy(HCM), which is known as genetic disease, severity and location of left ventricular hypertrophy(LVH) is variable. So we investigated additional modify role of angintensin-I converting enzyme(ACE) gene,...
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Screening of the Presence of Hepatitis B and C Virus Infections in Terminally Failing Human Hearts

Choe SC, Kim HS, Oh BH

In order to evaluate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in terminally failing hearts, we screened the explanted hearts of transplantation recipients for...
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A Case of Dilated Cardiomyopathy Associated with Autosomal Dominant Polycystic Kidney Disease

Choe SC, Jeon ES, Hwang SD

  • KMID: 1571916
  • J Korean Soc Echocardiogr.
  • 2001 Dec;9(2):152-156.
Autosomal dominant polycystic kidney disease is a systemic disorder with cystic manifestations in the kidneys, liver, pancreas, seminal vesicles, and meninges; its noncystic manifestations affect mostly the vascular, cardiac, and...
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A Case Report of Infective Endocarditis that Caused by Gemella Haemolysans in a Patient with Ventricular Septal Defect

Kim YC, Lee MS, Kim BY, Lee JW, Lim DS, Kang JA, Kim JH, Sung BY, Choe SC, Seong IW, Jeon ES

Infective endocarditis is the infectious disease that produces vegetation on endocardium. Acute bacterial endocarditis is most frequently caused by Staphylococcus aureus, occurs on a normal heart valve, and subacute endocarditis...
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A 54 kDa cysteine protease purified from the crude extract of Neodiplostomum seoulense adult worms

Choi MH, Choe SC, Lee SH

As a preliminary study for the explanation of pathobiology of Neodiplostomum seoulense infection, a 54 kDa protease was purified from the crude extract of adult worms by sequential chromatographic...
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The Analysis of Mitochondrial DNA in the Failing and Normal Hearts

Choi HS, Kim HS, Oh BH, Lee MM, Choe SC, Hong SK, Sohn DW, Park YB, Choi YS, Seo JD, Lee YW

  • KMID: 2251563
  • Korean J Med.
  • 1997 Sep;53(3):404-413.
OBJECTIVE: The aim of this study is to analyze the mitochondrial DNA in failing and normal hearts. METHODS: Genomic DNA was extracted from 18 failing and 4 normal hearts. The DNA...
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Permanent pacemaker implantation via coronary sinus

Choi HS, Lee MY, Lee MY, Choe SC, Choi YJ, Kim HS, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Lee YW

We report a case of successful ventricular pacing via the coronary sinus in a 34 year-old female patient admitted because of repetitive dizziness and syncope. She had rheumatic valvular disease...
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Screening of the Presence of Enterovirus and Cytomegalovirus Infections in Terminally Failing Human Hearts

Choe SC, Kim SY, Hong SK, Kim HS, Oh BH

BACKGROUND: In order to evaluate the prevalence of enterovirus and cytomegalovirus infections to terminally failing hearts, the presence of enteroviral RNA and cytomegaloviral DNA was screened in the explanted hearts...
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Differentiation of Korean isolates of Entamoeba histolytica from Entamoeba dispar

Choe SC, Lee M, Lee SK, Im K, Tannich E, Lee SH, Hong ST

Cysts of Entamoeba histolytica are still found from humans in Korea, but not all of the cysts are known as pathogenic. The non-pathogenic strain is regarded as a different species,...
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Safety and efficacy of fimasartan with essential hypertension patients in real world clinical practice: data from a post marketing surveillance in Korea

Han SE, Jeong SH, Kang HJ, Hong MS, Paek E, Cho H, Choe SC

The safety and efficacy of fimasartan have been evaluated through post-marketing surveillance in real world clinical practice. The multi-center, prospective, open-label and non-interventional study. A total of 3,945 patients (3,729...
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Korean multicenter clinical trial of simvastatin ( KS-1 study )

Shin HH, Kim KB, Kang JC, Son MS, Kim JH, Kim JS, Cho SY, Shin YW, Kim HS, Chae IH, Park YB, Choe SC, Seo JD, Bae JH, Rho YM, Lee WR, Chae SC, Kim KS, Ahn JC, Kim CH, Park JE, Lee CW, Jeong JW, Choe KH, Shin GJ, Rhee KJ, Ko JK, Hong SP, Ryoo UH, Jeon ES, Kim DW, Rim CY

  • KMID: 2143093
  • Korean J Med.
  • 1999 Nov;57(5):906-915.
The aim of this study was to investigate the efficacy of simvastatin to improved lipid profiles in hypercholesterolemic Korean patients. METHODS: From 25 hospitals in Korea, 478 hypercholesterolemic patients were enrolled from November...
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Use of Oral Antibiotics in Elderly Gastrointestinal Patients

Choe SC, Lee DH

  • KMID: 2339432
  • J Korean Geriatr Soc.
  • 2012 Sep;16(3):108-113.
Oral antibiotics are usually prescribed for geriatric patients for the treatment of infectious diarrhea and management of hepatic encephalopathy. But oral antibiotics have systemic adverse events, so many doctors face...
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Incidence of eNOS gene mutationin Korean patients with coronary artery spasm

Kim JH, Lim BK, Kim BY, Lee JW, Kang JA, Lim DS, Lee MS, Kim YC, Sung BY, Choe SC, Seong IW, Jeon ES

BACKGROUND: Coronary artery spasm is an important mechanism in producing myocardial ischemia. But the exact mechanism of the spasm is not well known. We investigated the mutation of endothelial nitric...
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Prevalence of Cytomegalovirus Infections in the Terminally Failing Hearts from Korean Patients

Choe SC, Kim HS, Oh BH, Lee MM, Choi HS, Kim YJ, Sohn DW, Park YB, Choi YS, Seo JD, Lee YW

  • KMID: 2251560
  • Korean J Med.
  • 1997 Sep;53(3):380-388.
OBJECTIVE: In order to evaluate the prevalence of cytomegalovirus infection to terminally failing heart, cytomegaloviral DNA was detected in the explanted hearts of transplantation recipients. METHODS: DNA extractions were performed from...
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Antiatherogenic Effect of Naringin Independent of Lipid-Lowering Action in Hypercholesterolemic Rabbits

Choe SC, Kim HS, Jeong TS, Bok SH, Park YB

BACKGROUND: Naringin, one of the flavonoids in citrus fruit peels, is known to have antioxidant and hepatotonic effects in animal studies. We evaluated the effect of naringin on 1) blood...
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4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Its Effects on Coronary Artery Disease

Kang HJ, Han KH, Choe SC, Kim HS, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Lee YW

BACKGROUND: 4G allele of one base pair insertion/deletion polymorphism (4G/5G) at plasminogen activator inhibitor-1 (PAI-1) was associated with increased plasma activity of PAI-1. Increased plasma PAI-1 activity was associated with...
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Thrombolytic Therapy Followed by Myotomy of Gastrocnemius Muscle in Popliteal Artery Entrapment Syndrome

Jung IM, Seong IW, Choe SC, Jeon ES, Bae JS

  • KMID: 1941206
  • J Korean Soc Vasc Surg.
  • 2000 Nov;16(2):249-254.
Popliteal artery entrapment syndrome (PAES) is rare, but increasingly reported in the literature as a cause of lower limb arterial impairment. Management of a patient with PAES depends on the...
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