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Oncogenic Ras downregulates mdr1b expression through generation of reactive oxygen species

Jun S, Kim SW, Kim B, Chang IY, Park SJ

In the present study, we investigated the effect of oncogenic H-Ras on rat mdr1b expression in NIH3T3 cells. The constitutive expression of H-RasV12 was found to downregulate the mdr1b promoter...
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Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells

Youn CK, Park SJ, Li MH, Lee MY, Lee KY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ

Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine...
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Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells

Youn CK, Park SJ, Lee MY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ

  • KMID: 2170670
  • Biomol Ther.
  • 2013 Jul;21(4):258-263.
We demonstrate herein that silibinin, a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), inhibits LPS-induced activation of macrophages and production of nitric oxide (NO) in RAW 264.7 cells....
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Synergistic Induction of iNOS by IFN-gamma and Glycoprotein Isolated from Dioscorea batatas

Huong PT, Lee MY, Lee KY, Chang IY, Lee SK, Yoon SP, Lee DC, Jeon YJ

Dioscorea species continue to be used in traditional Chinese medicine, and represent a major source of steroid precursors for conventional medicine. In the previous study, We isolated glycoprotein (GDB) from...
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Developmental Strategy for Stem Cell Therapy Products in Regulatory Considerations

Chang IY, Kim KS

Expectation that stem cell therapy products will prove better and more effective in treating a variety of medical conditions continues to drive expanding research efforts. Stem cell therapy products consist...
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Heat Shock Proteins and Autophagy in Rats with Cerulein-Induced Acute Pancreatitis

Kim JN, Lee HS, Ryu SH, Kim YS, Moon JS, Kim CD, Chang IY, Yoon SP

  • KMID: 2284244
  • Gut Liver.
  • 2011 Dec;5(4):513-520.
BACKGROUND/AIMS: Heat shock proteins (HSPs) protect rats from cerulein-induced acute pancreatitis (AP) by preventing the subcellular redistribution of cathepsin B and the activation of trypsinogen. Autophagy plays a critical role...
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Bipolar Pulsed Radiofrequency Denervation of Third Occipital Nerve in Patient with Cervicogenic Headache: A case report

Lee SY, Sim WS, Lee SM, Chang IY

Pulsed or conventional radiofrequency (RF) denervation of the third occipital nerve (TON) is considered to be a safe and effective alternative for the treatment of pain originating from the cervical...
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The Expression of P53 and Phosphorylation of H2AX in Germ Cells of Varicocele Rats

Cho WJ, Yeo MH, You HJ, Chang IY, Moon HY, Kim CS

PURPOSE: To explore the expressions of P53 and phosphorylation-H2AX in varicocele-induced rat testes. MATERIALS AND METHODS: A total of 16 adult male Sprague-Dawley rats underwent an operation; 12 underwent an...
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Intracerebral Hemorrhage after Vesicolitholapaxy under Spinal Anesthesia: A case report

Kim EJ, Chang IY

Intracerebral hemorrhage is a rare complication of spinal anesthesia. We report a case in a 83-year-old man with a history of Alzheimer dementia who underwent vesicolitholapaxy with spinal anesthesia and...
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Activation of Macrophage by Polysaccharide Isolated from Salicornia herbacea L.

Im JS, Lee SK, Chang IY, Ha HC, Lim Y, Kim HY, Park KH, Yoon SP

  • KMID: 1512979
  • Korean J Phys Anthropol.
  • 2006 Jun;19(2):117-124.
Salicornia herbacea L. is one of the halophytes that can grow in salt marshes, or salt fields along the seashores in Korea. The objective of this study is to investigate...
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Inhibition of p65 Nuclear Translocation by KIOM-79

Kim JS, Jang DS, Jeon YJ, You HJ, Park KH, Ming J, Moon HY, Yoon SP, Chang IY

  • KMID: 1937821
  • Korean J Anat.
  • 2006 Apr;39(2):103-110.
We demonstrate that KIOM-79, combined extracts isolated from Magnolia officinalis, Pueraria lobata, Glycyrrhiza uralensis, and Euphorbia pekinensis, inhibits LPS-induced expression of iNOS gene in RAW 264.7 cells. Treatment of RAW...
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Changes of Calretinin-Immunoreactivities in the Rat Superior Collicuclus after Eye Enucleation

Yoon SP, Kim HY, Jun YJ, Chang IY

  • KMID: 2283207
  • Korean J Phys Anthropol.
  • 2005 Sep;18(3):179-186.
Calcium-binding proteins play an important role in the protection, differentiation, and reorganization of the central nervous system. The effects of neonatal retinal deafferentiation on calretinin, and tracing of retinotectal pathway...
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iNOS Induction by Polysaccharide Isolated from Astragalus membranaceus

Jeon YJ, Yoon SP, You HJ, Chang IY

  • KMID: 2071894
  • Korean J Phys Anthropol.
  • 2005 Jun;18(2):131-138.
Astragalus membranaceus is used as a natural herbal medicine in East Asia for preventing carcinogenesis and reducing side effects induced by chemotherapy in cancer patients. Although the mechanism of anti-tumor...
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Expression of Bradykinin Receptors and Effects of Bradykinin in the Interstitial Cells of Cajal from Mouse Small Intestine

Koh YY, Jun JY, Choi S, Lim Y, Kim JS, Moon HS, Kim MY, Cho KW, Cho HH, Chang IY

  • KMID: 1609552
  • Korean J Phys Anthropol.
  • 2004 Dec;17(4):289-295.
Interstitial Cells of Cajal (ICC) are pacemaker cells that generates slow waves and drive spontaneous mechanical contractions of gastrointestinal smooth muscle. Slow waves are generated the periodic activation of spontaneous...
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Activation of Macrophage by PCSC22 Isolated from Poria cocos Sclerotium

Lee KY, Jeon YJ, Oh JH, Chang IY

  • KMID: 1609479
  • Korean J Phys Anthropol.
  • 2004 Sep;17(3):241-248.
The sclerotium of Poria cocos Wolf, which grows on the roots of pine trees, has long been used as a sedative, diuretic, and anti-inflammatory agent. The accumulating data revealed that...
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Calcitonin Gene-related Peptide Immunoreactivity in the Muscle Layer of Small Intestine; Its Action on Interstitial Cell

Yoon SP, Jun JY, Lim Y, Kim IJ, Kim JY, Kim JM, Chang IY

  • KMID: 1609465
  • Korean J Phys Anthropol.
  • 2004 Sep;17(3):207-214.
In addition to the central and the peripheral nervous system, calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) has been identified throughout the enteric nervous system. Several functions of the CGRP in gastrointestinal...
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Nuclear Translocation of NF-kappaB/Rel Component by PCSC22 Isolated from Poria cocos Sclerotium

Lee KY, Kim HY, Jeon YJ, Chang IY

  • KMID: 2224510
  • Korean J Anat.
  • 2004 Jun;37(3):301-308.
The sclerotium of Poria cocos Wolf, which grows on the roots of pine trees, has long been used as a sedative and diuretic (Chang and But, 1987). The accumulating data...
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Vanilloid Receptor Type-1 Immunoreactivities in the Mouse Myenteric Plexus: Immunohistochemical and Electrophysiological Study

Jun JY, Yang ES, Kim KH, Chang IY

  • KMID: 1517133
  • Korean J Phys Anthropol.
  • 2004 Mar;17(1):45-53.
The vanilloid receptor type-1 (VR1) is a nonselective cation channel activated by capsaicin and can be act as mediator of chemical and physical stimuli that elicit pain. The presence of...
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Characterization of Pacemaking Currents in Cultured Interstitial Cells of Cajal from Mice Small Intestine

Chang SJ, Cho ET, Heo GS, Park CG, Kim MW, Chang IY, Shin MK, Cha KH, Yeum CH, Jun JY

  • KMID: 772533
  • Korean J Gastroenterol.
  • 2003 Aug;42(2):121-127.
BACKGROUND/AIMS: Gastrointestinal motility is initiated by the periodic generation of slow waves. Interstitial cells of Cajal (ICC) are pacemaker cells that generate slow waves and drive spontaneous mechanical contractions...
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Plasticity of Interstitial Cells of Cajal (ICC) and Intestinal Motility in Murine Small Bowel Obstruction

Jun JY, Kim JH, You HJ, Kim JY, Oh JW, Moon JS, Chang IY

  • KMID: 1917150
  • Korean J Phys Anthropol.
  • 2003 Jun;16(2):109-118.
Interstitial cells of Cajal (ICC) are the pacemakers in gastrointestinal slow wave, and also transduce signal inputs from the enteric nervous system to smooth muscle. The abnormal motility corresponded to...
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