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Effectiveness of Concomitant Chemoradiotherapy with Gemcitabine in Locally Advanced Cervical Cancer Patients with Comorbidities

Brau-Figueroa H, Arango-Bravo E, Castro-Eguiluz D, Galicia-Carmona T, Lugo-Alferez LA, Cruz-Bautista I, Jiménez-Lima R, Cetina-Pérez L

Purpose The standard treatment for locally advanced cervical cancer (LACC) is concomitant chemoradiotherapy with cisplatin (CDDP) followed by brachytherapy. The presence of comorbidities are risk factors for nephrotoxicity and are associated...
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Effect of Waiting Time from Pathological Diagnosis to Definitive Concurrent Chemoradiation for Cervical Cancer on Overall Survival

Noh KW, Kim B, Choi CH, Kim TJ, Lee JW, Kim BG, Bae DS, Cho WK, Park W, Lee YY

Purpose This study aimed to evaluate the effect of waiting time, from diagnosis to initiation of definitive concurrent chemoradiation (CCRT), on overall survival in cervical cancer patients. Materials and Methods Patients...
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Synthetic Computed Tomography Generation while Preserving Metallic Markers for Three-Dimensional Intracavitary Radiotherapy: Preliminary Study

Jin H, Kang S, Kang HC, Choi CH

Purpose: This study aimed to develop a deep learning architecture combining two task models to generate synthetic computed tomography (sCT) images from low-tesla magnetic resonance (MR) images to improve metallic...
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Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors

Choi S, Lee SH, Park S, Park SH, Park C, Key J

Purpose: Indocyanine green (ICG) is a promising agent for intraoperative visualization of tumor tissues and sentinel lymph nodes in early-stage gynecological cancer. However, it has some limitations, including a short...
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Rectal mobilization for laparoscopic pelvic lymphadenectomy of the lower paracervical pathway in patients with uterine cancer

Kisu I, Nomura H, Iida M, Banno K, Shiraishi T, Iijima M, Nakamura K, Matsuda K, Hirao N

Objective The pelvic lymphatic drainage system comprises the upper and lower paracervical pathways (LPPs). Lymph node dissection of the LPP, including the cardinal ligament, internal iliac, internal common iliac, and presacral...
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Evaluation of partial genotyping with HPV16/18 for triage of HPV positive, cytology negative women in the COMPACT study

Hanley SJ, Fujita H, Aoyama-Kikawa S, Kasamo M, Torigoe T, Matsuno Y, Noriaki S, for the COMPACT study group

Objective While cytology-based screening programs have significantly reduced mortality and morbidity from cervical cancer, the global consensus is that primary human papillomavirus (HPV) testing increases detection of high-grade cervical intraepithelial neoplasia...
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Fertility-sparing surgery for women with stage I cervical cancer of 4 cm or larger: a systematic review

Donato VD, Caruso G, Sassu CM, Santangelo G, Bogani G, Plotti F, Sorbi F, Perniola G, Palaia I, Terrin G, Angioli R, Panici PB, Muzii L

Objective To investigate current evidence on oncological, fertility and obstetric outcomes of patients with stage I cervical cancer of 4 cm or larger undergoing fertility-sparing surgery (FSS). Methods Systematic review of studies including...
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Long-term outcomes of cervical cancer patients with complete metabolic response after definitive chemoradiotherapy

Onal C, Guler OC, Reyhan M, Yapar AF

Objective We investigated the importance of metabolic parameters measured with 18F-fluorodeoxyglucose positron-emission tomography integrated with computed tomography (FDG-PET/CT) for predicting progression-free survival (PFS) and overall survival (OS) in cervical cancer with...
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Laterally extended parametrectomy

Căpîlna ME, Ungár L, Cozlea AL, Gheorghe M, Stanca M, Lintner B, Moldovan AA

Objective To describe the laterally extended parametrectomy (LEP) surgical technique, emphasizing the main challenges of the procedure. Methods LEP was designed as a more radical surgical procedure aiming to remove the...
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Significance of serum CA125 level in surgically resected cervical adenocarcinoma with adverse features

Kim N, Park W, Cho WK, Bae DS, Kim BG, Lee JW, Choi CH, Kim TJ, Lee YY

Objective Unlike cervical squamous cell carcinoma, there are no consensus criteria for serum tumor markers in cervical adenocarcinoma. This study aimed to identify the prognostic value of preoperative carbohydrate antigen 125...
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Autologous cervical tumor lysate pulsed dendritic cell stimulation followed by cisplatin treatment abrogates FOXP3+ cells in vitro

Dhandapani H, Seetharaman A, Jayakumar H, Ganeshrajah S, Singh SS, Thangarajan R, Ramanathan P

Objective Dendritic cells (DCs) are administered as immunotherapeutic adjuvants after the completion of standard treatment in most settings. However, our Phase I trial indicated that one patient out of four, who...
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Practical issues and research trends of oncofertility in gynecologic cancer

Park JY

In recent years, there has been a greater impetus toward preserving fertility in young women with gynecologic cancer. This is related to the increasing incidence of gynecologic cancer in young...
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Patterns of definitive radiotherapy practice for cervical cancer in South Korea: a survey endorsed by the Korean Radiation Oncology Group (KROG 20-06)

Kim N, Park W

Objective: The Korean Radiation Oncology Group conducted a nationwide questionnaire survey to evaluate the patterns of clinical practice for patients with cervical cancer receiving definitive radiation therapy (RT) in South...
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The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee

Ikeda M, Shida M, Shigeta S, Nagase S, Takahashi F, Yamagami W, Katabuchi H, Yaegashi N, Aoki D, Mikami M

Objective: The Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007. The aim of this research was to evaluate the influence of...
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The prognostic significance of tumor-infiltrating lymphocytes in cervical cancer

He M, Wang Y, Zhang G, Cao K, Yang M, Liu H

Objective: To predict the prognosis of cervical cancer, we constructed a novel model with 5 specific cell types and identified a potential biomarker. Methods: We employed CIBERSORT and xCell method to...
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Vaginal delivery after robot-assisted uterine artery-preserving radical trachelectomy for early-stage cervical cancer

Lee N, Mun J, Park SJ, Lee EJ, Lee S, Kim HS

Radical trachelectomy is conducted in women with early stage cervical cancer who strongly desire fertility preservation. To improve fertility outcomes, the preservation of the uterine artery has been suggested, which...
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The first-round results of a populationbased cohort study of HPV testing in Japanese cervical cancer screening: baseline characteristics, screening results, and referral rate

Kono K, Morisada T, Saika K, Aoki ES, Miyagi E, Ito K, Takahashi H, Nakayama T, Saito H, Aoki D

Objective: In 2013, a cohort study aimed to clarify the positive and negative effects of introducing the human papillomavirus (HPV) testing for population-based cervical cancer screening has been launched in...
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Lymph Node Ratio Is a Strong Prognostic Factor in Patients with Early-Stage Cervical Cancer Undergoing Minimally Invasive Radical Hysterectomy

Kim SI, Kim TH, Lee M, Kim HS, Chung HH, Lee TS, Jeon HW, Kim JW, Park NH, Song YS

Purpose: To determine whether the prognostic impact of lymph node ratio (LNR), defined as the ratio between the number of positive lymph nodes and removed lymph nodes, differs between open...
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Comparison between laparoscopic and abdominal radical hysterectomy for stage IB1 and tumor size <2 cm cervical cancer with visible or invisible tumors: a multicentre retrospective study

Li P, Chen L, Ni Y, Liu J, Li D, Guo J, Liu Z, Jin S, Xu Y, Li Z, Wang L, Bin X, Lang J, Liu P, Chen C

Objective: To compare 5-year disease-free survival (DFS) and overall survival (OS) rates of laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for stage IB1 and tumor size
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Total laparoscopic vs. conventional open abdominal nerve-sparing radical hysterectomy: clinical, surgical, oncological and functional outcomes in 301 patients with cervical cancer

Ceccaroni M, Roviglione G, Malzoni M, Cosentino F, Spagnolo E, Clarizia R, Casadio P, Seracchioli R, Ghezzi F, Mautone D, Bruni F, Uccella S

Objective: Total laparoscopic nerve-sparing radical hysterectomy (TL-NSRH) has been considered a promising approach, however, surgical, clinical, oncological and functional outcomes have not been systematically addressed. We present a large retrospective...
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