- Prognostic Value of Combined Programmed Cell Death 1 Ligand and p16 Expression Predicting Responsiveness to Radiotherapy in Patients with Oropharyngeal Squamous Cell Carcinoma
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Kwon M, Kim DH, Cho KJ, Kim Y, Kim JP, Jeong BK, Lee JS, Seo JH, Park JJ
- KMID: 2469956
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2019 Dec;62(12):712-719.
- doi: 10.3342/kjorl-hns.2019.00619
BACKGROUND AND OBJECTIVES: This study examined the expressions of p16 and the programmed cell death 1 ligand (PD-L1) in patients with oropharyngeal cancer (OPC) treated with radiotherapy (RT) to identify... -
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- Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells
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Moon D, Kim J
- KMID: 2459547
- Anat Cell Biol.
- 2019 Sep;52(3):312-323.
- doi: 10.5115/acb.18.192
Cyclosporin A (CsA) does not only exert a toxic effect on kidney parenchymal cells, but also protects them against necrotic cell death by inhibiting opening of mitochondrial permeability transition pore.... -
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- Cell Death Mechanisms in Esophageal Squamous Cell Carcinoma Induced by Vesicular Stomatitis Virus Matrix Protein
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Douzandegan Y, Tahamtan A, Gray Z, Nikoo HR, Tabarraei , Moradi A
- KMID: 2456577
- Osong Public Health Res Perspect.
- 2019 Aug;10(4):246-252.
- doi: 10.24171/j.phrp.2019.10.4.08
OBJECTIVES: Vesicular stomatitis virus (VSV) is under development as an oncolytic virus due to its preferential replication in cancer cells and oncolytic activity, however the viral components responsible have not... -
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- Guanabenz Acetate Induces Endoplasmic Reticulum Stress–Related Cell Death in Hepatocellular Carcinoma Cells
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Kang HJ, Seol HS, Lee SE, Suh YA, Kim J, Jang SJ, Yu E
- KMID: 2465448
- J Pathol Transl Med.
- 2019 Mar;53(2):94-103.
- doi: 10.4132/jptm.2019.01.14
BACKGROUND: Development of chemotherapeutics for the treatment of advanced hepatocellular carcinoma (HCC) has been lagging. Screening of candidate therapeutic agents by using patient-derived preclinical models may facilitate drug discovery for... -
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- Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress
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Kang Y, Lee JH, Seo YH, Jang JH, Jeong CH, Lee S, Jeong GS, Park B
- KMID: 2442005
- Biomol Ther.
- 2019 Feb;27(2):145-151.
- doi: 10.4062/biomolther.2018.092
Methamphetamine (METH) acts strongly on the nervous system and damages neurons and is known to cause neurodegenerative diseases such as Alzheimer's and Parkinson's. Flavonoids, polyphenolic compounds present in green tea,... -
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- Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
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Han X, Kang KA, Piao MJ, Zhen AX, Hyun YJ, Kim HM, Ryu YS, Hyun JW
- KMID: 2432065
- Biomol Ther.
- 2019 Jan;27(1):41-47.
- doi: 10.4062/biomolther.2018.047
The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated... -
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- Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
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Ali A, Kim MJ, Kim MY, Lee HJ, Roh GS, Kim HJ, Cho GJ, Choi WS
- KMID: 2430195
- Anat Cell Biol.
- 2018 Dec;51(4):274-283.
- doi: 10.5115/acb.2018.51.4.274
Hyper-O-GlcNAcylation is a general feature of cancer which contributes to various cancer phenotypes, including cell proliferation and cell growth. Quercetin, a naturally occurring dietary flavonoid, has been reported to reduce... -
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- Cyanidin-3-glucoside inhibits amyloid β₂₅₋₃₅-induced neuronal cell death in cultured rat hippocampal neurons
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Yang JS, Jeon S, Yoon KD, Yoon SH
- KMID: 2430091
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):689-696.
- doi: 10.4196/kjpp.2018.22.6.689
Increasing evidence implicates changes in [Ca²âº]i and oxidative stress as causative factors in amyloid beta (Aβ)-induced neuronal cell death. Cyanidin-3-glucoside (C3G), a component of anthocyanin, has been reported to protect... -
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- Dapsone modulates lipopolysaccharide-activated bone marrow cells by inducing cell death and down-regulating tumor necrosis factor-α production
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Kwon MJ, Joo HG
- KMID: 2427022
- J Vet Sci.
- 2018 Nov;19(6):744-749.
- doi: 10.4142/jvs.2018.19.6.744
Dapsone, an antibiotic, has been used to cure leprosy. It has been reported that dapsone has anti-inflammatory activity in hosts; however, the anti-inflammatory mechanism of dapsone has not been fully... -
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- Melanoma Cell Death Mechanisms
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Broussard , Howland A, Ryu S, Song K, Norris D, Armstrong , Song PI
- KMID: 2420880
- Chonnam Med J.
- 2018 Sep;54(3):135-142.
- doi: 10.4068/cmj.2018.54.3.135
Over recent years, several new molecular and immunogenic therapeutic approaches to melanoma treatment have been approved and implemented in clinical practice. Mechanisms of resistance to these new therapies have become... -
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- Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)
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Kondo T, Yoshida S, Nagai H, Takeshita , Mino M, Morioka H, Nakajima T, Kusakabe K, Okada T
- KMID: 2417565
- J Vet Sci.
- 2018 Jul;19(4):505-511.
- doi: 10.4142/jvs.2018.19.4.505
In Mongolian gerbils, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia, due to an incomplete circle of Willis, resulting in delayed neuronal cell death in the Cornet... -
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- Inhibitory effect of the leaves and stems of Actinidia arguta on Aβ (25–35)-induced neuronal cell death and memory impairment
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Kang SG, Seong YH
- KMID: 2435752
- J Biomed Transl Res.
- 2018 Jun;19(2):26-31.
- doi: 10.12729/jbtr.2018.19.2.026
Actinidia arguta (Actinidiaceae), which is commonly referred to as hardy kiwifruit, has been reported to possess anti-inflammatory, anti-allergic and antioxidative properties. The protective effect of the leaves and stems of... -
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- The Phosphodiesterase 4 Inhibitor Roflumilast Protects against Cigarette Smoke Extract-Induced Mitophagy-Dependent Cell Death in Epithelial Cells
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Kyung SY, Kim YJ, Son ES, Jeong SH, Park JW
- KMID: 2420602
- Tuberc Respir Dis.
- 2018 Apr;81(2):138-147.
- doi: 10.4046/trd.2017.0115
BACKGROUND: Recent studies show that mitophagy, the autophagy-dependent turnover of mitochondria, mediates pulmonary epithelial cell death in response to cigarette smoke extract (CSE) exposure and contributes to the development of... -
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- Black Rice (Oryza sativa L., Poaceae) Extract Reduces Hippocampal Neuronal Cell Death Induced by Transient Global Cerebral Ischemia in Mice
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Hwang SN, Kim JC, Bhuiyan MI, Kim JY, Yang JS, Yoon SH, Yoon KD, Kim SY
- KMID: 2410474
- Exp Neurobiol.
- 2018 Apr;27(2):129-138.
- doi: 10.5607/en.2018.27.2.129
Rice is the most commonly consumed grain in the world. Black rice has been suggested to contain various bioactive compounds including anthocyanin antioxidants. There is currently little information about the... -
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- Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide
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Lee AY, Choi JM, Lee MH, Lee J, Lee S, Cho EJ
- KMID: 2407805
- Nutr Res Pract.
- 2018 Apr;12(2):93-100.
- doi: 10.4162/nrp.2018.12.2.93
BACKGROUND/OBJECTIVE: Oxidative stress plays a key role in neuronal cell damage, which is associated with neurodegenerative disease. The aim of present study was to investigate the neuroprotective effects of perilla... -
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- Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells
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Moon H, Jang JH, Jang TC, Park GH
- KMID: 2429057
- Biomol Ther.
- 2018 Mar;26(2):175-181.
- doi: 10.4062/biomolther.2018.009
Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts... -
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- Cilostazol attenuates kainic acid-induced hippocampal cell death
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Park YS, Jin Z, Jeong EA, Yi CO, Lee JY, Park IS, Roh GS
- KMID: 2398556
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):63-70.
- doi: 10.4196/kjpp.2018.22.1.63
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate... -
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- Polyvinylidene Fluoride Alters Inflammatory Responses by Activation-induced Cell Death in Macrophages
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Kim HG, Kim SH, Kim TS, Park TW, Won R, Park HD, Choi SA, Jung YW
- KMID: 2400626
- Immune Netw.
- 2017 Dec;17(6):402-409.
- doi: 10.4110/in.2017.17.6.402
Carbon nanotubes (CNTs) are nanomaterials that have been employed in generating diverse materials. We previously reported that CNTs induce cell death in macrophages, possibly via asbestosis. Therefore, we generated CNT-attached... -
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- Novel non-apoptotic cell death: ferroptosis
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Woo SM, Kwon TK
- KMID: 2400352
- Yeungnam Univ J Med.
- 2017 Dec;34(2):174-181.
- doi: 10.12701/yujm.2017.34.2.174
Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic... -
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- Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress
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Kim B, Kim J, Kim YS
- KMID: 2399898
- Anat Cell Biol.
- 2017 Dec;50(4):293-300.
- doi: 10.5115/acb.2017.50.4.293
Cyclooxygenase-2 (COX-2) is an enzyme induced by various proinflammatory and mitogenic stimuli. Celecoxib is a selective inhibitor of COX-2 that have been shown to affect cell growth and apoptosis. Lung... -
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