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Cellular Senescence in Arterial Diseases

Shimizu I, Minamino T

Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the...
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Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway

Kim SG, Sung JY, Kim JR, Choi HC

Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance...
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Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway

Kim I, Park CS, Lee HY

BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and...
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Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes

Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY

Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and...
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Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis

Lim CJ, Lee YM, Kang SG, Lim HW, Shin KO, Jeong SK, Huh YH, Choi S, Kor M, Seo HS, Park BD, Park K, Ahn JK, Uchida Y, Park K

Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only...
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Survive or thrive: tradeoff strategy for cellular senescence

Park SC

Aging-dependent cellular behaviors toward extrinsic stress are characterized by the confined localization of certain molecules to either nuclear or perinuclear regions. Although most growth factors can activate downstream signaling in...
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Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling

Song J, Lee B, Kang S, Oh Y, Kim E, Kim CH, Song HT, Lee JE

Neuronal senescence caused by diabetic neuropathy is considered a common complication of diabetes mellitus. Neuronal senescence leads to the secretion of pro-inflammatory cytokines, the production of reactive oxygen species, and...
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Enhanced Viral Replication by Cellular Replicative Senescence

Kim JA, Seong RK, Shin OS

Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of...
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The dependence of nitric oxide synthase inhibition caused by cigarette smoking extract on the cellular aging of bovine aortic endothelial cells

Le V, Kim YH, Min J

OBJECTIVES: Cigarette smoking had been recorded as the main cause of impaired endothelium- dependent vasodilation in smokers by reducing nitric oxide (NO), a production of endothelial nitric oxide synthase (eNOS)....
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Effects of Replicative Senescence on the Cell Cycle Regulation in Human Gingival Fibroblasts

Park YC, Yang DS, Kim JH, Kim HA, You YO, You HK, Shin HS

Gingival fibroblasts are major cellular component of gingiva. However, the molecular mechanisms of senescence of human gingival fibroblasts are unknown. Human fibroblasts undergo replicative senescence in vitro after a limited...
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Replicative Senescence and Differentiation Properties of Reconstituted Skin and Monolayer Human Keratinocytes in Vitro

Doh YH, Liu Y, Sung HK, Jung TE, Park JH, Kim JY, Song IH, Lee YC, Sung EG

  • KMID: 1558765
  • Korean J Anat.
  • 2001 Dec;34(6):553-565.
This experiment tried to elucidate the characteristics of senescence and differentiation in the reconstituted skin and the monolayer cultured human keratinocytes in vitro, respectively. While the keratinocytes were cultivated from...
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Effects of Retinoic Acid on Replicative Senescence and Apoptosis of Normal Human Oral Keratinocytes

You YO, Min SK, Kim SN, Kim KJ, Chun SW, Seo SJ, Kim KH, Lee DK

  • KMID: 1921220
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2001 Nov;23(6):481-492.
No abstract available.
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Measurement of Replicative Senescence in Long Term Cultured Human Keratinocytes

Yoon KH, Yin L, Song IH, Sung HK, Kim JY, Park JH, Lee YC, Sung EG

  • KMID: 2224526
  • Korean J Anat.
  • 2000 Dec;33(6):643-650.
The keratinocyte culture has been used for the reconstruction of artificial skin or as in vitro skin model. For these purpose, keratinocytes should be cultured for long time (usually 10...
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