- Induction of Melanoma Cell-Selective Apoptosis Using Anti-HER2 Antibody-Conjugated Gold Nanoparticles
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Jeon HJ, Choi BB, Park KH, Hwang DS, Kim UK, Kim GC
- KMID: 2446955
- Yonsei Med J.
- 2019 Jun;60(6):509-516.
- doi: 10.3349/ymj.2019.60.6.509
PURPOSE: This study was conducted to verify the induction and mechanism of selective apoptosis in G361 melanoma cells using anti-HER2 antibody-conjugated gold nanoparticles (GNP-HER2). MATERIALS AND METHODS: Following GNP-HER2 treatment of... -
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- Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis
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Schlossberger V, Worni M, Kihm C, Montani M, Datz C, Hampe J, Stickel F
- KMID: 2434394
- Gut Liver.
- 2019 Jan;13(1):77-82.
- doi: 10.5009/gnl18037
BACKGROUND/AIMS: Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments... -
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- Anti-growth Effects of Imatinib and GNF5 via Regulation of Skp2 in Human Hepatocellular Carcinoma Cells
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Kim SH, Kim MO, Kim KR
- KMID: 2447448
- J Cancer Prev.
- 2018 Dec;23(4):170-175.
- doi: 10.15430/JCP.2018.23.4.170
BACKGROUND: Human hepatocellular carcinoma (HCC) is a common liver tumor and the main cause of cancer-related death. Tyrosine kinase inhibitors, such as imatinib and GNF5 which were developed to treat... -
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- ABT-737 ameliorates docetaxel resistance in triple negative breast cancer cell line
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Hwang E, Hwang SH, Kim J, Park JH, Oh S, Kim YA, Hwang KT
- KMID: 2422933
- Ann Surg Treat Res.
- 2018 Nov;95(5):240-248.
- doi: 10.4174/astr.2018.95.5.240
PURPOSE: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). METHODS: Western blot analysis... -
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- Effect of caspases and RANKL induced by heavy force in orthodontic root resorption
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Minato Y, Yamaguchi , Shimizu M, Kikuta J, Hikida T, Hikida M, Suemitsu M, Kuyama K, Kasai K
- KMID: 2417967
- Korean J Orthod.
- 2018 Jul;48(4):253-261.
- doi: 10.4041/kjod.2018.48.4.253
OBJECTIVE: Orthodontic root resorption (ORR) due to orthodontic tooth movement is a difficult treatment-related adverse event. Caspases are important effector molecules for apoptosis. At present, little is known about the... -
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- Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
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Liu Q, Cao Y, Zhou P, Gui S, Wu X, Xia Y, Tu J
- KMID: 2421743
- Biomol Ther.
- 2018 May;26(3):328-334.
- doi: 10.4062/biomolther.2017.042
Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary... -
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- Reactive oxygen species-dependent apoptosis induction by water extract of Citrus unshiu peel in MDA-MB-231 human breast carcinoma cells
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Kim MY, Choi EO, HwangBo H, Kwon DH, Ahn KI, Kim HJ, Ji SY, Hong SH, Jeong JW, Kim GY, Park C, Choi YH
- KMID: 2407809
- Nutr Res Pract.
- 2018 Apr;12(2):129-134.
- doi: 10.4162/nrp.2018.12.2.129
BACKGROUND/OBJECTIVES: Although several recent studies have reported the anti-cancer effects of extracts or components of Citrus unshiu peel, which has been used for various purposes in traditional medicine, the molecular... -
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- 17-DMAG has the Potentiated Anticancer Effects Against Hepatocellular Carcinoma Cells by Transfection of the Gene Encoding Hepatitis B Viral X Protein
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Lee CS, Kim OH, Hong HE, Jeon SJ, Won SS, Kim SJ
- KMID: 2396567
- J Liver Cancer.
- 2017 Sep;17(2):126-135.
- doi: 10.17998/jlc.17.2.126
BACKGROUND/AIMS: Hepatitis B viral protein X (HBx) is implicated in the pathogenesis of hepatocellular carcinoma (HCC) as well as the elevation of heat shock proteins (HSPs) after hepatitis B virus... -
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- Flavonoids: A new generation molecule to stimulate programmed cell deaths in cancer cells
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Venkatarame Gowda Saralamma V, Kim EH, Lee HJ, Raha S, Lee WS, Heo JD, Lee SJ, Won CK, Kim GS
- KMID: 2377353
- J Biomed Transl Res.
- 2017 Mar;18(1):30-37.
- doi: 10.12729/jbtr.2017.18.1.030
Programmed cell death (PCD) is decisive in eliminating affected cells in human cancers, whereas there are increasing cases of cancer-related death due to side effects of modern treatment methods. There... -
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- Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis
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Deka SJ, Mamdi N, Manna D, Trivedi V
- KMID: 2362922
- J Breast Cancer.
- 2016 Dec;19(4):358-371.
- doi: 10.4048/jbc.2016.19.4.358
PURPOSE: The protein kinase C (PKC) family of serine-threonine kinases plays an important role in cancer cell progression. Thus, molecules that target PKC have potential as anticancer agents. The current... -
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- Novel functional roles of caspase-related genes in the regulation of apoptosis and autophagy
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Shin JH, Min SH
- KMID: 2364261
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):573-580.
- doi: 10.4196/kjpp.2016.20.6.573
Caspases, a family of cysteine proteases, cleave substrates and play significant roles in apoptosis, autophagy, and development. Recently, our group identified 72 genes that interact with Death Caspase-1 (DCP-1) proteins... -
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- Bacillus spp. or Bacillus spp.-Derived Membrane Vesicles Induce the Intrinsic Pathways of Apoptosis of Human Colon Cancer Cell Lines
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Yang M, Jang IT, Kim HJ, Park JK
- KMID: 2327903
- J Bacteriol Virol.
- 2016 Jun;46(2):84-92.
- doi: 10.4167/jbv.2016.46.2.84
The striking increase in colorectal cancer (CRC) has shown the great fatality in Korea for more than 15 years. The leading edge of this rising incidence rate is mainly due... -
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- Inhibitory Effect of Apocynin on Proteasome Inhibition-Induced Apoptosis in Differentiated PC12 Cells
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Kang JH, Han SW, Han JH, Kim DE, Lee CS
- KMID: 2163256
- J Korean Neurol Assoc.
- 2016 May;34(2):116-123.
- doi: 10.17340/jkna.2016.2.5
BACKGROUND: The dysfunction of the proteasome system has been implicated in neuronal degeneration. Apocynin, a specific inhibitor for nicotinamide adenine dinucleotide phosphate oxidase, has anti-inflammatory and anti-oxidant effects. However, the... -
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- Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
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Zhao H, Liu W, Wang Y, Dai N, Gu J, Yuan Y, Liu X, Bian J, Liu ZP
- KMID: 2344302
- J Vet Sci.
- 2015 Sep;16(3):297-306.
- doi: 10.4142/jvs.2015.16.3.297
Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell... -
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- Apoptosis: role in myeloid cell development
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Sarvothaman S, Undi RB, Pasupuleti SR, Gutti U, Gutti RK
- KMID: 2172770
- Blood Res.
- 2015 Jun;50(2):73-79.
- doi: 10.5045/br.2015.50.2.73
Hematopoiesis is the process that generates blood cells in an organism from the pluripotent stem cells. Hematopoietic stem cells are characterized by their ability to undergo self-renewal and differentiation. The... -
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- The Histone Deacetylase Inhibitor Trichostatin A Sensitizes Human Renal Carcinoma Cells to TRAIL-Induced Apoptosis through Down-Regulation of c-FLIP(L)
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Han MH, Park C, Kwon TK, Kim GY, Kim WJ, Hong SH, Yoo YH, Choi YH
- KMID: 2380360
- Biomol Ther.
- 2015 Jan;23(1):31-38.
- doi: 10.4062/biomolther.2014.092
Histone acetylation plays a critical role in the regulation of transcription by altering the structure of chromatin, and it may influence the resistance of some tumor cells to tumor necrosis... -
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- Degradation of the Transcription Factors NF-kappaB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
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Kim KA, Min A, Lee YA, Shin MH
- KMID: 1792210
- Korean J Parasitol.
- 2014 Oct;52(5):459-469.
- doi: 10.3347/kjp.2014.52.5.459
Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of... -
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- Amoebic PI3K and PKC Is Required for Jurkat T Cell Death Induced by Entamoeba histolytica
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Lee YA, Kim KA, Min A, Shin MH
- KMID: 1792196
- Korean J Parasitol.
- 2014 Aug;52(4):355-365.
- doi: 10.3347/kjp.2014.52.4.355
The enteric protozoan parasite Entamoeba histolytica is the causative agent of human amebiasis. During infection, adherence of E. histolytica through Gal/GalNAc lectin on the surface of the amoeba can induce... -
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- Inhibitory Effect of 3,4,5-Tricaffeoylquinic Acid on Parkinsonian Toxin 1-Methyl-4-phenylpyridinium-induced Apoptosis
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Joo JJ, Kang JH, Han JH, Kim DE, Lee CS
- KMID: 2191157
- J Korean Neurol Assoc.
- 2014 May;32(2):72-81.
BACKGROUND: 1-Methyl-4-phenylpyridinium (MPP+) causes a neuronal cell injury that is similar to the findings observed in Parkinson's disease. Caffeoylquinic acid derivatives have demonstrated anti-oxidant and anti-inflammatory effects. Nevertheless, the effect... -
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- Parthenolide Sensitizes Human Colorectal Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand through Mitochondrial and Caspase Dependent Pathway
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Trang KT, Kim SL, Park SB, Seo SY, Choi CH, Park JK, Moon JC, Lee ST, Kim SW
- KMID: 2174335
- Intest Res.
- 2014 Jan;12(1):34-41.
- doi: 10.5217/ir.2014.12.1.34
BACKGROUND/AIMS: Combination therapy utilizing tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in conjunction with other anticancer agents, is a promising strategy to overcome TRAIL resistance in malignant cells. Recently, parthenolide... -
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