- The Effect of Capsaicin on Neuroinflammatory Mediators of Rosacea
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Kim HB, Na EY, Yun SJ, Lee JB
- KMID: 2531873
- Ann Dermatol.
- 2022 Aug;34(4):261-269.
- doi: 10.5021/ad.21.223
Background: Rosacea is a chronic inflammatory skin disease with a pathophysiological mechanism that remains unclear. Recently, dysregulation of the sensory nerve system has been implicated in the development of this... -
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- The ability of orexin-A to modify pain-induced cyclooxygenase-2 and brain-derived neurotrophic factor expression is associated with its ability to inhibit capsaicin-induced pulpal nociception in rats
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Shahsavari F, Abbasnejad M, Esmaeili-Mahani S, Raoof M
- KMID: 2530981
- Korean J Pain.
- 2022 Jul;35(3):261-270.
- doi: 10.3344/kjp.2022.35.3.261
Background: The rostral ventromedial medulla (RVM) is a critical region for the management of nociception. The RVM is also involved in learning and memory processes due to its relationship with... -
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- Capsaicin Reduces Ethanol Consumption in C57BL/6 but not DBA/2 Mice
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Huh SY, Kim SG, Kim HK
- KMID: 2530469
- Clin Psychopharmacol Neurosci.
- 2022 May;20(2):343-349.
- doi: 10.9758/cpn.2022.20.2.343
Objective: Capsaicin, the pungent analgesic substance of hot peppers which produces a burning sensation and pain is known to affect Substance P and central opioid activities. This experiment was designed... -
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- Pathophysiological Role of TLR4 in Chronic Relapsing Itch Induced by Subcutaneous Capsaicin Injection in Neonatal Rats
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Kim HJ, Lee EH, Lim YH, Jeong D, Na HS, Jung Y
- KMID: 2536247
- Immune Netw.
- 2022 Apr;22(2):e20.
- doi: 10.4110/in.2022.22.e20
Despite the high prevalence of chronic dermatitis and the accompanied intractable itch, therapeutics that specifically target itching have low efficacy. Increasing evidence suggests that TLRs contribute to immune activation and... -
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- Effect of Oropharyngeal Sensory Stimulation Using Capsaicin in Acute Stroke Patients with Dysphagia
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Bae H, Lee E
- KMID: 2521671
- J Korean Crit Care Nurs.
- 2021 Oct;14(3):73-86.
- doi: 10.34250/jkccn.2021.14.3.73
Purpose : This study aimed to investigate the effects of oropharyngeal sensory stimulation using low-temperature capsaicin on dysphagia, dietary level, aspiration pneumonia, and nutritional status in acute stroke patients with... -
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- Ononis spinosa alleviated capsaicin-induced mechanical allodynia in a rat model through transient receptor potential vanilloid 1 modulation
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Jaffal SM, Al-Najjar BO, Abbas MA
- KMID: 2517511
- Korean J Pain.
- 2021 Jun;34(3):262-270.
- doi: 10.3344/kjp.2021.34.3.262
Background: Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel implicated in pain sensation in response to heat, protons, and capsaicin (CAPS). It is well established that TRPV1... -
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- Topical agents: a thoughtful choice for multimodal analgesia
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Choi E, Nahm FS, Han WK, Lee PB, Jo J
- KMID: 2506867
- Korean J Anesthesiol.
- 2020 Oct;73(5):384-393.
- doi: 10.4097/kja.20357
For over a thousand years, various substances have been applied to the skin to treat pain. Some of these substances have active ingredients that we still use today. However,... -
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- Comparison of the deleterious effects of yaji and cadmium chloride on testicular physiomorphological and oxidative stress status: The gonadoprotective effects of an omega-3 fatty acid
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Ekhoye EI, Olerimi SE, Ehebha SE
- KMID: 2506139
- Clin Exp Reprod Med.
- 2020 Sep;47(3):168-179.
- doi: 10.5653/cerm.2019.03517
Objective This study investigated testicular oxidative stress status and physiomorphological function in Wistar rats fed with yaji and cadmium chloride (CdCl2). Methods: Sixty male albino Wistar rats (12 per group) were... -
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- Capsaicin-Induced Apoptosis in MBT-2 Murine Bladder Tumor Cells and Bladder Wall Penetration Effect of the Nano-Encapsulated Capsaicin in Rabbit
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Cho SJ, Moon HW, Bae WJ, Park YH, Ha US, Hong SH, Kim SW, Lee JY
- KMID: 2470402
- Korean J Urol Oncol.
- 2019 Dec;17(3):168-177.
- doi: 10.22465/kjuo.2019.17.3.168
PURPOSE: In this study, we attempted to characterize capsaicin's effects with regard to the apoptosis of murine bladder cancer cells (MBT-2) as well as the pharmacodynamics of nano-encapsulated capsaicin formulation... -
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- Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity
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Lai K, Long L, Yi F, Tang J, Chen Z, Chen F, Zhou J, Peng W, Zhang L, Li H, Zhan W, Chen R, Luo W, Chen Q, Chung KF, Zhong N
- KMID: 2459190
- Allergy Asthma Immunol Res.
- 2019 Nov;11(6):871-884.
- doi: 10.4168/aair.2019.11.6.871
PURPOSE: An older female predominance has been reported among chronic cough patients in Western countries, which is considered to be associated with a higher cough sensitivity in females. However, the... -
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- Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level
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Pearce LV, Ann J, Blumberg P, Lee J
- KMID: 2456217
- Biomol Ther.
- 2019 Sep;27(5):435-441.
- doi: 10.4062/biomolther.2019.013
The capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) has been an object of intense interest for pharmacological development on account of its critical role in nociception. In the course... -
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- Modalities in managing postherpetic neuralgia
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Shrestha M, Chen A
- KMID: 2421514
- Korean J Pain.
- 2018 Oct;31(4):235-243.
- doi: 10.3344/kjp.2018.31.4.235
Postherpetic neuralgia (PHN) is the most troublesome side effect of Herpes Zoster (HZ), which mainly affects the elderly and immunocompromised populations. Despite the current advancement of treatments, PHN persists in... -
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- Neonatal Bladder Irritation Is Associated With Vanilloid Receptor TRPV1 Expression in Adult Rats
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Park JS, Jung HD, Cho YS, Jin MH, Hong CH
- KMID: 2422504
- Int Neurourol J.
- 2018 Sep;22(3):169-176.
- doi: 10.5213/inj.1836020.101
PURPOSE: To evaluate whether mild chemical irritation of the bladder in neonatal rats is associated with persistent vanilloid receptor transient receptor potential vanilloid subfamily 1 (TRPV1) activity in adult rats. METHODS:... -
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- Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats
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Kooshki R, Abbasnejad M, Esmaeili Mahani S, Raoof M, Moeini Aghtaei MM, Dabiri S
- KMID: 2417955
- Korean J Pain.
- 2018 Jul;31(3):174-182.
- doi: 10.3344/kjp.2018.31.3.174
BACKGROUND: The trigeminal nucleus caudalis (Vc) is a primary central site for trigeminal transmitting. Noxious stimulation of the trigeminal nociceptors alters the central synaptic releases and neural expression of some... -
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- Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder
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Chang HH, Chang SJ, Hsieh CH, Hsu CK, Yang SS
- KMID: 2417780
- Int Neurourol J.
- 2018 Jun;22(2):83-89.
- doi: 10.5213/inj.1836078.039
PURPOSE: The urinary bladder (UB) is innervated by both sensory and autonomic nerves. Recent studies have shown that sensory neuropeptides induced contractions in the detrusor muscle. Therefore, in a mouse... -
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- The effects of regular exercise on capsaicin-induced pulpal pain and pain-induced changes in passive avoidance learning and memory in rats
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Raoof M, Shakoori A, Kooshki R, Abbasnejad M, Amanpour S
- KMID: 2392902
- Korean J Pain.
- 2017 Oct;30(4):258-264.
- doi: 10.3344/kjp.2017.30.4.258
BACKGROUND: Pulpal pain is one of the most common and severe orofacial pain conditions with considerable adverse effects on physiological processes including learning and memory. Regular exercise is known to... -
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- Esophageal Submucosal Injection of Capsaicin but Not Acid Induces Symptoms in Normal Subjects
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Lee RH, Korsapati , Bhalla V, Varki N, Mittal RK
- KMID: 2327948
- J Neurogastroenterol Motil.
- 2016 Jul;22(3):436-443.
- doi: 10.5056/jnm15166
BACKGROUND/AIMS: Transient receptor potential vanilloid-1 (TRPV1) is a candidate for mediating acid-induced symptoms in the esophagus. We conducted studies to determine if the presence of acid in the mucosa/submucosa and... -
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- Effect of capsicum plaster at the P6 acupoint on postoperative nausea and vomiting in patients undergoing endoscopic sinus surgery
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Kim JM, Kim KS, Koo MS, Kwon MY, Kim GH, Kim JE, Yun MJ, Lee SY
- KMID: 2358478
- Anesth Pain Med.
- 2016 Apr;11(2):160-165.
- doi: 10.17085/apm.2016.11.2.160
BACKGROUND: We evaluated the efficacy of capsicum plaster, applied to the Chinese acupuncture point (acupoint) Pericardium 6 (P6), in reducing postoperative nausea and vomiting (PONV) in patients who underwent endoscopic... -
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- Considerable Variability in the Efficacy of 8% Capsaicin Topical Patches in the Treatment of Chronic Pruritus in 3 Patients with Notalgia Paresthetica
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Andersen H, Sand C, Elberling
- KMID: 2429486
- Ann Dermatol.
- 2016 Feb;28(1):86-89.
- doi: 10.5021/ad.2016.28.1.86
Notalgia paresthetica (NP) is a focal neuropathic itch condition manifesting in intense chronic or recurrent episodic itch in a hyperpigmented, macular, uni- or bilateral skin area located below and/or medially... -
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- Postoperative nausea and vomiting after capsicum plaster at the P6 acupoint after laparoscopic cholecystectomy according to gender
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Kim KN, Kim KS, Lee HJ, Oh SY
- KMID: 2148010
- Anesth Pain Med.
- 2015 Oct;10(4):261-266.
- doi: 10.17085/apm.2015.10.4.261
BACKGROUND: Postoperative nausea and vomiting (PONV) has a remarkably high reported incidence (70%) in female patients after anesthesia. This study aims to evaluate the clinical effect of capsicum plaster at... -
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