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Characterization of Oncolytic Vaccinia Virus Harboring the Human IFNB1 and CES2 Transgenes

Cho E, Islam SMBU, Jiang F, Park JE, Lee B, Kim ND, Hwang TH

  • Cancer Res Treat.
  • 2020 Jan;52(1):309-319.
  • doi: 10.4143/crt.2019.161
Purpose The purpose of this study was to assess characteristics of SJ-815, a novel oncolytic vaccinia virus lacking a functional thymidine kinase-encoding TK gene, and instead, having two human transgenes: the...
Prognostic Model for Survival and Recurrence in Patients with Early-Stage Cervical Cancer: A Korean Gynecologic Oncology Group Study (KGOG 1028)

Paik ES, Lim MC, Kim MH, Kim YH, Song ES, Seong SJ, Suh DH, Lee JM, Lee C, Choi CH

  • Cancer Res Treat.
  • 2020 Jan;52(1):320-333.
  • doi: 10.4143/crt.2019.124
Purpose We aimed to develop and validate individual prognostic models in a large cohort of cervical cancer patients that were primarily treated with radical hysterectomy. Materials and Methods We analyzed 1,441 patients with...
Time Trends for Prostate Cancer Incidence from 2003 to 2013 in South Korea: An Age-Period-Cohort Analysis

Lee HY, Kim DK, Doo SW, Yang WJ, Song YS, Lee B, Kim JH

  • Cancer Res Treat.
  • 2020 Jan;52(1):301-308.
  • doi: 10.4143/crt.2019.194
Purpose Prostate cancer (PCa) incidence is affected by aging phenomenon and performance of screening test. In United States, PCa incidence is affected by period effect of U.S. Preventive Services Task Force...
Clinical Characteristics and Outcomes of Non-small Cell Lung Cancer Patients with HER2 Alterations in Korea

Lee K, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ

  • Cancer Res Treat.
  • 2020 Jan;52(1):292-300.
  • doi: 10.4143/crt.2019.186
Purpose Human epidermal growth factor receptor 2 (HER2) alterations are found in approximately 1%-3% of non-small cell lung cancers (NSCLCs). We evaluated the clinical features and outcomes of NSCLC harboring HER2...
Osimertinib in Patients with T790M-Positive Advanced Non-small Cell Lung Cancer: Korean Subgroup Analysis from Phase II Studies

Ahn MJ, Han JY, Kim DW, Cho BC, Kang JH, Kim SW, Yang JCH, Mitsudomi , Lee JS

  • Cancer Res Treat.
  • 2020 Jan;52(1):284-291.
  • doi: 10.4143/crt.2019.200
Purpose Osimertinib is a third-generation, irreversible, oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that potently and selectively inhibits both EGFR sensitizing mutation and EGFR T790M and has demonstrated...
Clinical Characteristics of Clear Cell Ovarian Cancer: A Retrospective Multicenter Experience of 308 Patients in South Korea

Lee HY, Hong JH, Byun JH, Kim HJ, Baek SK, Kim JY, Kim KH, Yun J, Kim JA, Park K, Lee HJ, Lee JL, Won YW, Kim IH, Bae WK, Park KH, Sun DS, Lee S, Lee MY, Lee GJ, Hong SH, Jung YH, An HJ

  • Cancer Res Treat.
  • 2020 Jan;52(1):277-283.
  • doi: 10.4143/crt.2019.292
Purpose The purpose of this study was to evaluate clinical characteristics and treatment pattern of ovarian clear cell carcinoma (OCCC) in Korea and the role of adjuvant chemotherapy in early stage. Materials and...
Pancreatic High-Grade Neuroendocrine Neoplasms in the Korean Population: A Multicenter Study

Kim H, An S, Lee K, Ahn S, Park DY, Kim JH, Kang DW, Kim MJ, Chang MS, Jung ES, Kim JM, Choi YJ, Jin SY, Chang HK, Cho MY, Kang YK, Kang M, Ahn S, Kim YW, Hong SM, on behalf of the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists

  • Cancer Res Treat.
  • 2020 Jan;52(1):263-276.
  • doi: 10.4143/crt.2019.192
Purpose The most recent 2017 World Health Organization (WHO) classification of pancreatic neuroendocrine neoplasms (PanNENs) has refined the three-tiered 2010 scheme by separating grade 3 pancreatic neuroendocrine tumors (G3 PanNETs) from...
Clinical Outcomes of Second-Line Chemotherapy after Progression on Nab-Paclitaxel Plus Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Lee K, Bang K, Yoo C, Hwang I, Jeong JH, Chang HM, Oh D, Song TJ, Park DH, Lee SS, Lee SK, Kim MH, Park Jh, Kim Kp, Ryoo BY

  • Cancer Res Treat.
  • 2020 Jan;52(1):254-262.
  • doi: 10.4143/crt.2019.190
Purpose Since the introduction of nab-paclitaxel plus gemcitabine (nab-P+GEM) as first-line (1L) treatment for metastatic pancreatic adenocarcinoma (mPDAC), optimal second-line (2L) chemotherapy after progression is unclear. We assessed clinical outcomes of...
Immunogenicity and Optimal Timing of 13-Valent Pneumococcal Conjugate Vaccination during Adjuvant Chemotherapy in Gastric and Colorectal Cancer: A Randomized Controlled Trial

Choi W, Kim JG, Beom SH, Hwang JE, Shim HJ, Cho SH, Shin MH, Jung SH, Chung IJ, Song JY, Bae WK

  • Cancer Res Treat.
  • 2020 Jan;52(1):246-253.
  • doi: 10.4143/crt.2019.189
Purpose Pneumococcal vaccination (13-valent pneumococcal conjugate vaccine [PCV13]) is recommended to cancer patients undergoing systemic chemotherapy. However, the optimal time interval between vaccine administration and initiation of chemotherapy has been little...
Anterior Gradient 3 Promotes Breast Cancer Development and Chemotherapy Response

Xu Q, Shao Y, Zhang J, Zhang H, Zhao Y, Liu X, Guo Z, Chong W, Gu F, Ma Y

  • Cancer Res Treat.
  • 2020 Jan;52(1):218-245.
  • doi: 10.4143/crt.2019.217
Purpose Anterior gradient 3 (AGR3) belongs to human anterior gradient (AGR) family. The function of AGR3 on cancer remains unknown. This research aimed to investigate if AGR3 had prognostic values in...
Inequalities in Awareness and Attitude towards HPV and Its Vaccine between Local and Migrant Residents Who Participated in Cervical Cancer Screening in Shenzhen, China

Lin W, Wang Y, Liu Z, Chen B, Yuan S, Wu B, Gong L

  • Cancer Res Treat.
  • 2020 Jan;52(1):207-217.
  • doi: 10.4143/crt.2019.053
Purpose A cross-sectional survey was conducted to evaluate the differences on awareness and attitude towards human papillomavirus (HPV) and its vaccine between local and migrant residents who participated in cervical...
Diabetes Mellitus Is Associated with Inferior Prognosis in Patients with Chronic Lymphocytic Leukemia: A Propensity Score-Matched Analysis

Gao R, Man TS, Liang JH, Wang L, Zhu HY, Wu W, Fan L, Li JY, Yang T, Xu W

  • Cancer Res Treat.
  • 2020 Jan;52(1):189-206.
  • doi: 10.4143/crt.2019.122
Purpose Diabetes mellitus (DM) is associated with elevated cancer risk and poor survival outcome in malignancies. The objective of this study was to evaluate the prognostic value of preexisting DM in...
Factors Influencing Imatinib-Induced Hepatotoxicity

Han JM, Yee J, Cho YS, Gwak HS

  • Cancer Res Treat.
  • 2020 Jan;52(1):181-188.
  • doi: 10.4143/crt.2019.131
Purpose Although imatinib-induced hepatotoxicity may aggravate the patient’s clinical condition and alter the treatment plan, the underlying mechanism of and factors influencing imatinibinduced hepatotoxicity have rarely been investigated. The purpose of...
Clinical Outcomes of Postoperative Radiotherapy Following Radical Prostatectomy in Patients with Localized Prostate Cancer: A Multicenter Retrospective Study (KROG 18-01) of a Korean Population

Lee SU, Cho KH, Park W, Cho WK, Kim JS, Wee CW, Kim YS, Kim JH, Nam TK, Cho J, Jeong SM, Kim Y, Shim SJ, Choi Y, Kim JS

  • Cancer Res Treat.
  • 2020 Jan;52(1):167-180.
  • doi: 10.4143/crt.2019.126
Purpose The purpose of this study was to investigate the clinical outcomes of postoperative radiotherapy (PORT) patients who underwent radical prostatectomy for localized prostate cancer. Materials and Methods Localized prostate cancer patients who...
Therapeutic Co-targeting of WEE1 and ATM Downregulates PD-L1 Expression in Pancreatic Cancer

Jin MH, Nam AR, Park JE, Bang JH, Bang YJ, Oh DY

  • Cancer Res Treat.
  • 2020 Jan;52(1):149-166.
  • doi: 10.4143/crt.2019.183
Purpose Pancreatic cancer (PC) is one of the most lethal cancers worldwide, but there are currently no effective treatments. The DNA damage response (DDR) is under investigation for the development of...
Prevalence and Predictors of Sustained Smoking after a Cancer Diagnosis in Korean Men

Koo HY, Lee K, Park SM, Chang J, Kim K, Choi S, Cho MH, Jun J, Kim SM

  • Cancer Res Treat.
  • 2020 Jan;52(1):139-148.
  • doi: 10.4143/crt.2018.609
Purpose Although smoking has a significant impact on mortality and morbidity of cancer patients, many patients continue to smoke post-diagnosis. The purpose of this study was to investigate prevalence and predictors...
Identification of Significant Prognostic Tissue Markers Associated with Survival in Upper Urinary Tract Urothelial Carcinoma Patients Treated with Radical Nephroureterectomy: A Retrospective Immunohistochemical Analysis Using Tissue Microarray

Kim SH, Park WS, Park B, Chung J, Joung JY, Lee KH, Seo HK

  • Cancer Res Treat.
  • 2020 Jan;52(1):128-138.
  • doi: 10.4143/crt.2019.119
Purpose The purpose of this study was to identify prognostic tissue markers for several survival outcomes after radical nephroureterectomy among patients with upper urinary tract urothelial carcinoma using tissue microarray and...
Pediatric Adenocarcinoma in Korea: A Multicenter Study

Yang HB, Namgoong J, Kim KH, Kim DY, Park J, Shin HB, Youn JK, Lee S, Lee JW, Jung SE, Chung JH, Choe YM, Heo TG, Ho IG, Kim HY

  • Cancer Res Treat.
  • 2020 Jan;52(1):117-127.
  • doi: 10.4143/crt.2019.092
Purpose Adenocarcinoma is an extremely rare malignancy in the pediatric population. Research regarding pediatric adenocarcinoma is very rare in Korea. This study aimed to investigate the clinical features of pediatric adenocarcinomas...
Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma

Dai L, Fang Q, Li P, Wu J, Zhang X

  • Cancer Res Treat.
  • 2020 Jan;52(1):109-116.
  • doi: 10.4143/crt.2019.202
Purpose The main goal of this study was to analyze the prognosis of secondary oral squamous cell carcinoma (SCC) with a comparison with sporadic oral SCC by a matched-pair design. Materials and...
High-Throughput Multiplex Immunohistochemical Imaging of the Tumor and Its Microenvironment

Koh J, Kwak Y, Kim J, Kim WH

  • Cancer Res Treat.
  • 2020 Jan;52(1):98-108.
  • doi: 10.4143/crt.2019.195
Purpose The aim of this study was to develop a formalin-fixed paraffin-embedded (FFPE) tissue based multiplex immunochemistry (mIHC) method for high-throughput comprehensive tissue imaging and demonstrate its feasibility, validity, and usefulness. Materials...

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