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Diffuse Large B-Cell Lymphoma Arising within Ileal Neobladder: An Expanding Spectrum of Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation

Lee H, Shin H, Kim NY, Park HS, Park J

  • Cancer Res Treat.
  • 2019 Oct;51(4):1666-1670.
  • doi: 10.4143/crt.2019.022
Diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI), specifically arising in ileal neobladder, is a rare neoplasm. We present an unusual case of Epstein–Barr virus (EBV)–positive DLBCL-CI arising within...
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis

Li N, Piao J, Wang X, Kim KY, Bae JY, Ren X, Lin Z

  • Cancer Res Treat.
  • 2019 Oct;51(4):1653-1665.
  • doi: 10.4143/crt.2018.544
PURPOSE: This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. MATERIALS AND METHODS: The expression of Paip1 in normal cervical epithelial tissues and...
Validation of the 8th AJCC Cancer Staging System for Pancreas Neuroendocrine Tumors Using Korean Nationwide Surgery Database

You Y, Jang JY, Kim SC, Yoon YS, Park JS, Cho CK, Park SJ, Yang JD, Lee WJ, Hong TH, Ahn KS, Jeong CY, Lee HK, Lee SE, Roh YH, Kim HJ, Kim H, Han IW

  • Cancer Res Treat.
  • 2019 Oct;51(4):1639-1652.
  • doi: 10.4143/crt.2019.023
PURPOSE: The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic neuroendocrine tumor (PNET) included several significant changes. We aim to evaluate this staging system...
Feasibility Study of Physician Orders for Life-Sustaining Treatment for Patients with Terminal Cancer

An HJ, Jeon HJ, Chun SH, Jung HA, Ahn HK, Lee KH, Kim MH, Kim JH, Cheon J, Kim J, Koh SJ

  • Cancer Res Treat.
  • 2019 Oct;51(4):1632-1638.
  • doi: 10.4143/crt.2019.009
PURPOSE: Physician Orders for Life-Sustaining Treatment (POLST) form is a legal document for terminally ill patients to make medical decisions with physicians near the end-of-life. A multicenter prospective study was...
Low Doses of Nonylphenol Promote Growth of Colon Cancer Cells through Activation of ERK1/2 via G Protein‒Coupled Receptor 30

Xie M, Liang JL, Huang HD, Wang MJ, Zhang T, Yang XF

  • Cancer Res Treat.
  • 2019 Oct;51(4):1620-1631.
  • doi: 10.4143/crt.2018.340
PURPOSE: Nonylphenol (NP) is an endocrine disruptor found in products such as cleaners, plastics, and detergents. It exerts actions similar to endogenous 17β-estradiol (E2) and is reported to influence various...
Validity and Reliability of Korean Version of Simplified Nutritional Appetite Questionnaire in Patients with Advanced Cancer: A Multicenter, Longitudinal Study

Oh SY, Koh SJ, Baek JY, Kwon KA, Jeung HC, Lee KH, Won YW, Lee HJ

  • Cancer Res Treat.
  • 2019 Oct;51(4):1612-1619.
  • doi: 10.4143/crt.2018.505
PURPOSE: Malnutrition and a loss of muscle mass are frequent in cancer patients and have a negative effect on clinical outcome. Nutrition risk screening aims to increase awareness and allow...
Prognostic Value of Post-diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea

Mai TT, Choi JH, Lee MK, Chang YJ, Jung SY, Cho H, Lee ES

  • Cancer Res Treat.
  • 2019 Oct;51(4):1600-1611.
  • doi: 10.4143/crt.2018.426
PURPOSE: We aimed to evaluate health-related quality of life (HRQOL) at 1-year post-diagnosis in breast cancer (BC) patients and its association with overall survival using data from the National Cancer...
Treatment Outcome after Fractionated Conformal Radiotherapy for Hepatocellular Carcinoma in Patients with Child-Pugh Classification B in Korea (KROG 16-05)

Bae SH, Park HC, Yoon WS, Yoon SM, Jung IH, Lee IJ, Kim JW, Seong J, Kim TH, Nam TK, Choi Y, Lee SY, Jang HS, Lee DS, Kim JH

  • Cancer Res Treat.
  • 2019 Oct;51(4):1589-1599.
  • doi: 10.4143/crt.2018.687
PURPOSE: There is limited data on radiotherapy (RT) for hepatocellular carcinoma (HCC) in patients with Child-Pugh classification B (CP-B). This study aimed to evaluate the treatment outcomes of fractionated conformal...
Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma

Lee JB, Park HS, Park S, Lee HJ, Kwon KA, Choi YJ, Kim YJ, Nam CM, Cho NH, Kang B, Chung HC, Rha SY

  • Cancer Res Treat.
  • 2019 Oct;51(4):1578-1588.
  • doi: 10.4143/crt.2018.671
PURPOSE: Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment...
Inter-observer Reproducibility in the Pathologic Diagnosis of Gastric Intraepithelial Neoplasia and Early Carcinoma in Endoscopic Submucosal Dissection Specimens: A Multi-center Study

Kim JM, Sohn JH, Cho MY, Kim WH, Chang HK, Jung ES, Kook MC, Jin SY, Chae YS, Park YS, Kang MS, Kim H, Lee JH, Park DY, Kim KM, Kim H, Suh YJ, Seol SY, Jung HY, Kim DH, Lee NR, Park SH, You JH

  • Cancer Res Treat.
  • 2019 Oct;51(4):1568-1577.
  • doi: 10.4143/crt.2019.019
PURPOSE: The diagnostic criteria of gastric intraepithelial neoplasia (IEN) are controversial across the world. We investigated how many discrepancies occur in the pathologic diagnosis of IEN and early gastric carcinoma...
Characteristics, Prognostic Factors, and Survival of Patients with NK/T-Cell Lymphoma of Non-upper Aerodigestive Tract: A 17-Year Single-Center Experience

Liu ZL, Bi XW, Zhang XW, Lei DX, Liu PP, Yang H, Gao Y, Jiang YX, Jiang WQ, Xia Y

  • Cancer Res Treat.
  • 2019 Oct;51(4):1557-1567.
  • doi: 10.4143/crt.2018.681
PURPOSE: The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small...
Bevacizumab Plus Erlotinib Combination Therapy for Advanced Hereditary Leiomyomatosis and Renal Cell Carcinoma-Associated Renal Cell Carcinoma: A Multicenter Retrospective Analysis in Korean Patients

Choi Y, Keam B, Kim M, Yoon S, Kim D, Choi JG, Seo JY, Park I, Lee JL

  • Cancer Res Treat.
  • 2019 Oct;51(4):1549-1556.
  • doi: 10.4143/crt.2019.086
PURPOSE: Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare genetic syndrome resulting from germline mutations in fumarate hydratase. The combination of bevacizumab plus erlotinib showed promising interim results...
Clinical Significance of Pleural Attachment and Indentation of Subsolid Nodule Lung Cancer

Kim HJ, Cho JY, Lee YJ, Park JS, Cho YJ, Yoon HI, Chung JH, Cho S, Kim K, Lee KW, Lee JH, Lee CT

  • Cancer Res Treat.
  • 2019 Oct;51(4):1540-1548.
  • doi: 10.4143/crt.2019.057
PURPOSE: Lung cancers presenting as subsolid nodule commonly have peripheral location, making the cancer-pleura relationship noteworthy. We aimed to evaluate the effect of pleural attachment and/or indentation on visceral pleural...
BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 Therapy

Kim SB, Do IG, Tsang J, Kim TY, Yap YS, Cornelio G, Gong G, Paik S, Lee S, Ng TY, Park S, Oh HS, Chiu J, Sohn J, Lee M, Choi YJ, Lee EM, Park KH, Nathaniel , Ro J

  • Cancer Res Treat.
  • 2019 Oct;51(4):1527-1539.
  • doi: 10.4143/crt.2018.598
PURPOSE: BioPATH is a non-interventional study evaluating the relationship of molecular biomarkers (PTEN deletion/downregulation, PIK3CA mutation, truncated HER2 receptor [p95HER2], and tumor HER2 mRNA levels) to treatment responses in Asian...
Loss of LKB1 Protein Expression Correlates with Increased Risk of Recurrence and Death in Patients with Resected, Stage II or III Colon Cancer

Sfakianaki M, Papadaki C, Tzardi M, Trypaki M, Alam S, Lagoudaki , Messaritakis I, Zoras O, Mavroudis , Georgoulias V, Souglakos

  • Cancer Res Treat.
  • 2019 Oct;51(4):1518-1526.
  • doi: 10.4143/crt.2019.008
PURPOSE: The purpose of this study was to investigate the prognostic significance of liver kinase b1 (LKB1) loss in patients with operable colon cancer (CC). MATERIALS AND METHODS: Two hundred sixty-two...
Television Viewing Time and Breast Cancer Incidence for Japanese Premenopausal and Postmenopausal Women: The JACC Study

Cao J, Eshak ES, Liu K, Muraki I, Cui R, Iso H, Tamakoshi , JACC Study Group

  • Cancer Res Treat.
  • 2019 Oct;51(4):1509-1517.
  • doi: 10.4143/crt.2018.705
PURPOSE: The evidence on effects of TV viewing time among premenopausal and postmenopausal women for breast cancer risk remains controversial and limited. MATERIALS AND METHODS: A prospective study encompassing 33,276 (17,568...
Impact of Regional Nodal Irradiation for Breast Cancer Patients with Supraclavicular and/or Internal Mammary Lymph Node Involvement: A Multicenter, Retrospective Study (KROG 16-14)

Kim K, Jeong Y, Shin KH, Kim JH, Ahn SD, Kim SS, Suh CO, Kim YB, Choi DH, Park W, Cha J, Chun M, Lee DS, Lee SY, Kim JH, Park HJ, Jung W

  • Cancer Res Treat.
  • 2019 Oct;51(4):1500-1508.
  • doi: 10.4143/crt.2018.575
PURPOSE: The purpose of this study was to evaluate the treatment outcomes of radiotherapy (RT) for breast cancer with ipsilateral supraclavicular (SCL) and/or internal mammary (IMN) lymph node involvement. MATERIALS AND...
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Re-biopsy in Previously Treated Lung Cancer

Kim J, Kang HJ, Moon SH, Lee JM, Kim HY, Lee GK, Lee JS, Hwangbo B

  • Cancer Res Treat.
  • 2019 Oct;51(4):1488-1499.
  • doi: 10.4143/crt.2019.031
PURPOSE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used for the diagnosis and staging of lung cancer. However, evidence of its usefulness for re-biopsy in treated lung cancer, especially...
Prognostic Value of Baseline and Interim Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on ¹⁸F-FDG PET-CT in Patients with Follicular Lymphoma

Liang JH, Zhang YP, Xia J, Ding CY, Wu W, Wang L, Cao L, Zhu HY, Fan L, Li TN, Li JY, Xu W

  • Cancer Res Treat.
  • 2019 Oct;51(4):1479-1487.
  • doi: 10.4143/crt.2018.649
PURPOSE: The purpose of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) in patients with follicular lymphoma (FL) at...
Novel Prognostic Nomograms Based on Inflammation-Related Markers for Patients with Hepatocellular Carcinoma Underwent Hepatectomy

Wang Y, Sun K, Shen J, Li B, Kuang M, Cao Q, Peng S

  • Cancer Res Treat.
  • 2019 Oct;51(4):1464-1478.
  • doi: 10.4143/crt.2018.657
PURPOSE: Hepatocellular carcinoma (HCC) is an aggressive disease with high recurrence rate. However, current staging systems were lack of predictive capacity for HCC recurrence. We aimed to develop prognostic nomograms...

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