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41 results

ERRATUM: Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms

Kang J, Park JH, Lee HJ, Jo U, Park JK, Seo JH, Kim YH, Kim I, Park KH

  • Cancer Res Treat.
  • 2019 Jul;51(3):1257-1257.
  • doi: 10.4143/crt.2015.227.2
For the data represented in Fig. 4B, we have generated a new figure from one of these repeat experiments.
Prospective Validation of The Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy

Kim JW, Kim SH, Lee YG, Hwang IG, Kim JY, Koh SJ, Ko YH, Shin SH, Woo IS, Hong S, Kim TY, Baek JY, Kim HJ, Kim HJ, Lee MA, Kwon JH, Hong YS, Ryoo HM, Lee KH, Kim JH

  • Cancer Res Treat.
  • 2019 Jul;51(3):1249-1256.
  • doi: 10.4143/crt.2018.451
PURPOSE: The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned...
Higher Age Puts Lung Cancer Patients at Risk for Not Receiving Anti-cancer Treatment

Choi WI, Choi J, Kim MA, Lee G, Jeong J, Lee CW

  • Cancer Res Treat.
  • 2019 Jul;51(3):1241-1248.
  • doi: 10.4143/crt.2018.513
PURPOSE: We aimed to determine the demographic and epidemiologic variables that are associated with no treatment in lung cancer patients. MATERIALS AND METHODS: Patient data were collected from the Korean National...
Alterations in PD-L1 Expression Associated with Acquisition of Resistance to ALK Inhibitors in ALK-Rearranged Lung Cancer

Kim SJ, Kim S, Kim DW, Kim M, Keam B, Kim TM, Lee Y, Koh J, Jeon YK, Heo DS

  • Cancer Res Treat.
  • 2019 Jul;51(3):1231-1240.
  • doi: 10.4143/crt.2018.486
PURPOSE: The purpose of this study was to evaluate the relationships between the resistance of anaplastic lymphoma kinase (ALK)‒positive non-small cell lung cancer (NSCLC) to ALK inhibitors and the programmed...
Prognostic Value and Staging Classification of Lymph Nodal Necrosis in Nasopharyngeal Carcinoma after Intensity-Modulated Radiotherapy

Feng Y, Cao C, Hu Q, Chen X

  • Cancer Res Treat.
  • 2019 Jul;51(3):1222-1230.
  • doi: 10.4143/crt.2018.595
PURPOSE: The aim of the present study was to evaluate the prognostic value of magnetic resonance imaging (MRI)‒determined lymph nodal necrosis (LNN) in nasopharyngeal carcinoma (NPC) and explore the feasibility...
KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer

Zhou J, Chen WR, Yang LC, Wang J, Sun JY, Zhang WW, He ZY, Wu SG

  • Cancer Res Treat.
  • 2019 Jul;51(3):1207-1221.
  • doi: 10.4143/crt.2018.460
PURPOSE: The study aimed to search and identify genes that were differentially expressed in breast cancer, and their roles in cancer growth and progression. MATERIALS AND METHODS: The Gene Expression Omnibus...
Associations of Genetic Variations in Mismatch Repair Genes MSH3 and PMS1 with Acute Adverse Events and Survival in Patients with Rectal Cancer Receiving Postoperative Chemoradiotherapy

Yang J, Huang Y, Feng Y, Li H, Feng T, Chen J, Yin L, Wang W, Wang S, Liu Y, Song Y, Li Y, Jin J, Tan W, Lin D

  • Cancer Res Treat.
  • 2019 Jul;51(3):1198-1206.
  • doi: 10.4143/crt.2018.527
PURPOSE: Mismatch repair (MMR) deficiency plays a critical role in rectal cancer. This study aimed to explore the associations between genetic variations in seven MMR genes and adverse events (AEs)...
Impact of Mucin Proportion in the Pretreatment MRI on the Outcomes of Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiotherapy

Kim E, Kim K, Kim SH, Han SW, Kim TY, Jeong SY, Park KJ, Koh J, Kang GH, Chie EK

  • Cancer Res Treat.
  • 2019 Jul;51(3):1188-1197.
  • doi: 10.4143/crt.2018.434
PURPOSE: The purpose of this study was to evaluate treatment response to neoadjuvant chemoradiotherapy (CRT) with regard to mucin status in pathology and pretreatment magnetic resonance imaging (MRI) in locally...
Inherited NBN Mutations and Prostate Cancer Risk and Survival

Rusak B, Kluźniak , Wokołorczykv D, Stempa K, Kashyap A, Gronwald J, Huzarski T, Dębniak T, Jakubowska A, Masojć B, Akbari MR, Narodv SA, Lubiński , Cybulski C, The Polish Hereditary Prostate Cancer Consortium

  • Cancer Res Treat.
  • 2019 Jul;51(3):1180-1187.
  • doi: 10.4143/crt.2018.532
PURPOSE: The purpose of this study was to establish the contribution of four founder alleles of NBN to prostate cancer risk and cancer survival. MATERIALS AND METHODS: Five thousand one hundred...
Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer

Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ

  • Cancer Res Treat.
  • 2019 Jul;51(3):1167-1179.
  • doi: 10.4143/crt.2018.526
PURPOSE: The DNA damage response (DDR) is a multi-complex network of signaling pathways involved in DNA damage repair, cell cycle checkpoints, and apoptosis. In the case of biliary tract cancer...
High-Dose Thoracic Re-irradiation of Lung Cancer Using Highly Conformal Radiotherapy Is Effective with Acceptable Toxicity

Hong JH, Kim YS, Lee SW, Lee SJ, Kang JH, Hong SH, Hong JY, Cheon G

  • Cancer Res Treat.
  • 2019 Jul;51(3):1156-1166.
  • doi: 10.4143/crt.2018.472
PURPOSE: Thoracic re-irradiation (re-RT) of lung cancer has been challenged by the tolerance doses of normal tissues. We retrospectively analyzed local control, overall survival (OS) and toxicity after thoracic re-RT...
Development of Web-Based Nomograms to Predict Treatment Response and Prognosis of Epithelial Ovarian Cancer

Kim SI, Song M, Hwangbo S, Lee S, Cho U, Kim JH, Lee M, Kim HS, Chung HH, Suh DS, Park T, Song YS

  • Cancer Res Treat.
  • 2019 Jul;51(3):1144-1155.
  • doi: 10.4143/crt.2018.508
PURPOSE: Discovery of models predicting the exact prognosis of epithelial ovarian cancer (EOC) is necessary as the first step of implementation of individualized treatment. This study aimed to develop nomograms...
Prognostic Implications of Extranodal Extension in Relation to Colorectal Cancer Location

Kim CW, Kim J, Park Y, Cho DH, Lee JL, Yoon YS, Park IJ, Lim SB, Yu CS, Kim JC

  • Cancer Res Treat.
  • 2019 Jul;51(3):1135-1143.
  • doi: 10.4143/crt.2018.392
PURPOSE: Extranodal extension (ENE) is closely associated with the aggressiveness of both colon and rectal cancer. This study evaluated the clinicopathologic significance and prognostic impact of ENE in separate populations...
A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-Line Chemotherapy in Metastatic Colorectal Cancer Patients

Kim Y, Kim TW, Han SW, Ahn JB, Kim ST, Lee J, Park JO, Park YS, Lim HY, Kang WK

  • Cancer Res Treat.
  • 2019 Jul;51(3):1128-1134.
  • doi: 10.4143/crt.2018.379
PURPOSE: Simvastatin has demonstrated anti-tumor activity in preclinical studies via tumor cell senescence, apoptosis, and anti-angiogenesis. This phase II trial evaluated the efficacy and toxicity profile of conventional XELOX and...
Genetic Profiles Associated with Chemoresistance in Patient-Derived Xenograft Models of Ovarian Cancer

Li LY, Kim HJ, Park SA, Lee SH, Kim LK, Lee JY, Kim S, Kim YT, Kim SW, Nam EJ

  • Cancer Res Treat.
  • 2019 Jul;51(3):1117-1127.
  • doi: 10.4143/crt.2018.405
PURPOSE: Recurrence and chemoresistance (CR) are the leading causes of death in patients with high-grade serous carcinoma (HGSC) of the ovary. The aim of this study was to identify genetic...
Association between Body Mass Index and Gastric Cancer Risk According to Effect Modification by Helicobacter pylori Infection

Jang J, Cho EJ, Hwang Y, Weiderpass E, Ahn C, Choi J, Chang SH, Shin HR, Lim MK, Yoo KY, Park SK

  • Cancer Res Treat.
  • 2019 Jul;51(3):1107-1116.
  • doi: 10.4143/crt.2018.182
PURPOSE: Few studies investigated roles of body mass index (BMI) on gastric cancer (GC) risk according to Helicobacter pylori infection status. This study was conducted to evaluate associations between BMI...
Patient and Care Delays of Breast Cancer in China

Li YL, Qin YC, Tang LY, Liao YH, Zhang W, Xie XM, Liu Q, Lin Y, Ren ZF

  • Cancer Res Treat.
  • 2019 Jul;51(3):1098-1106.
  • doi: 10.4143/crt.2018.386
PURPOSE: This study differentiates patient and care delays of breast cancer and explores the related factors as well as the associations with the prognosis in Guangzhou, a southern city of...
Effect of Platinum-Based Chemotherapy on PD-L1 Expression on Tumor Cells in Non-small Cell Lung Cancer

Shin J, Chung JH, Kim SH, Lee KS, Suh KJ, Lee JY, Kim JW, Lee JO, Kim JW, Kim YJ, Lee KW, Kim JH, Bang SM, Lee JS

  • Cancer Res Treat.
  • 2019 Jul;51(3):1086-1097.
  • doi: 10.4143/crt.2018.537
PURPOSE: Programmed death-1 (PD-1)/PD-1 ligand (PD-L1) axis blockades have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). We assessed the effect of platinum-based chemotherapy on tumor PD-L1 expression...
A Nomogram for Predicting the Oncotype DX Recurrence Score in Women with T1-3N0-1miM0 Hormone Receptor‒Positive, Human Epidermal Growth Factor 2 (HER2)‒Negative Breast Cancer

Lee SB, Kim J, Sohn G, Kim J, Chung IY, Kim HJ, Ko BS, Son BH, Ahn SH, Lee JW, Jung KH

  • Cancer Res Treat.
  • 2019 Jul;51(3):1073-1085.
  • doi: 10.4143/crt.2018.357
PURPOSE: This preliminary study was conducted to evaluate the association between Oncotype DX (ODX) recurrence score and traditional prognostic factors. We also developed a nomogram to predict subgroups with low...
Oncologic, Perioperative Outcomes of Female Radical Cystectomy: Results from a Multicenter Study in Korea

Shim JS, Seo HK, Ku JH, Jeong BC, Hong B, Kang SH, UCART (Urothelial Cancer-Advanced Research and Treatment Group in Korea) Group

  • Cancer Res Treat.
  • 2019 Jul;51(3):1064-1072.
  • doi: 10.4143/crt.2018.515
PURPOSE: The lower incidence of bladder cancer among women has led to a lack of information on female radical cystectomy (RC). This study aimed to analyze the characteristics related with...

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