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TRIUMPH Trial: One Small Step Could Become One Giant Leap for Precision Oncology in Head and Neck Cancer

Keam B, Kim HR, Yun HJ

  • Cancer Res Treat.
  • 2019 Jan;51(1):413-414.
  • doi: 10.4143/crt.2018.335
No abstract available.
Rare Mechanism of Acquired Resistance to Osimertinib in Korean Patients with EGFR-mutated Non-small Cell Lung Cancer

Lee J, Shim JH, Park WY, Kim HK, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ

  • Cancer Res Treat.
  • 2019 Jan;51(1):408-412.
  • doi: 10.4143/crt.2018.138
Epidermal growth factor receptor (EGFR)‒tyrosine kinase inhibitors (TKIs) are effective clinical therapeutics for EGFR-mutant non-small cell lung cancer (NSCLC). Osimertinib, a thirdgeneration EGFR TKI, has proven effective against T790M mutations....
PTEN Mutation Identified in Patient Diagnosed with Simultaneous Multiple Cancers

Won HS, Chang ED, Na SJ, Whang IY, Lee DS, You SH, Kim YS, Kim JS

  • Cancer Res Treat.
  • 2019 Jan;51(1):402-407.
  • doi: 10.4143/crt.2017.579
PTEN hamartoma tumor syndrome is a spectrum of disorders characterized by unique phenotypic features including multiple hamartomas caused by mutations of the tumor suppressor gene PTEN. Cowden syndrome and Bannayan–Riley–Ruvalcaba...
NFATC3–PLA2G15 Fusion Transcript Identified by RNA Sequencing Promotes Tumor Invasion and Proliferation in Colorectal Cancer Cell Lines

Jang JE, Kim HP, Han SW, Jang H, Lee SH, Song SH, Bang D, Kim TY

  • Cancer Res Treat.
  • 2019 Jan;51(1):391-401.
  • doi: 10.4143/crt.2018.103
PURPOSE: This study was designed to identify novel fusion transcripts (FTs) and their functional significance in colorectal cancer (CRC) lines. MATERIALS AND METHODS: We performed paired-end RNA sequencing of 28 CRC...
Plasma Macrophage Migration Inhibitory Factor and CCL3 as Potential Biomarkers for Distinguishing Patients with Nasopharyngeal Carcinoma from High-Risk Individuals Who Have Positive Epstein-Barr Virus Capsid Antigen-Specific IgA

Xue N, Lin JH, Xing S, Liu D, Li SB, Lai YZ, Wang XP, Mao MJ, Zhong Q, Zeng MS, Liu WL

  • Cancer Res Treat.
  • 2019 Jan;51(1):378-390.
  • doi: 10.4143/crt.2018.070
PURPOSE: The purpose of this study was to identify novel plasma biomarkers for distinguishing nasopharyngeal carcinoma (NPC) patients from healthy individuals who have positive Epstein-Barr virus (EBV) viral capsid antigen...
Circulating Low Absolute CD4⁺ T Cell Counts May Predict Poor Prognosis in Extranodal NK/T-Cell Lymphoma Patients Treating with Pegaspargase-Based Chemotherapy

Zhang YP, Zhang R, Zhu HY, Wang L, Wu YJ, Liang JH, Shi WY, Liu H, Xu W, Li JY

  • Cancer Res Treat.
  • 2019 Jan;51(1):368-377.
  • doi: 10.4143/crt.2018.010
PURPOSE: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare subtype of non-Hodgkin lymphoma, and asparaginase-based regimens are the best first-line treatments. Data on the role of specific circulating...
Risk Factor Analysis for Secondary Malignancy in Dexrazoxane-Treated Pediatric Cancer Patients

Kim H, Kang HJ, Park KD, Koh KN, Im HJ, Seo JJ, Lee JW, Chung NG, Cho B, Kim HK, Lee JM, Hah JO, Lee JA, Lee YH, Park SK, Baek HJ, Kook H, Kim JY, Kim HS, Kim HM, Chueh HW, Park M, Yoon HS, Lee MJ, Choi HS, Ahn HS, Kawano Y, Park JW, Hahn S, Shin HY

  • Cancer Res Treat.
  • 2019 Jan;51(1):357-367.
  • doi: 10.4143/crt.2017.457
PURPOSE: Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, and elucidate risk factors for secondary malignancies...
Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion Weighted Imaging in Evaluating the Radio-sensitivity of Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiation Therapy

Xiao Y, Chen Y, Chen Y, He Z, Yao Y, Pan J

  • Cancer Res Treat.
  • 2019 Jan;51(1):345-356.
  • doi: 10.4143/crt.2018.089
PURPOSE: Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI)was evaluated regarding its ability to preliminarily predict the short-term treatment response of nasopharyngeal carcinoma (NPC) following intensity-modulated radiation therapy. MATERIALS AND METHODS: IVIM-DWI with...
Founder Mutations for Early Onset Melanoma as Revealed by Whole Exome Sequencing Suggests That This is Not Associated with the Increasing Incidence of Melanoma in Poland

Dębniak T, Scott RJ, Lea RA, Górski B, Masojć B, Cybulski C, Kram A, Maleszka R, Gromowski , Paszkowska-Szczur K, Kashyap A, Lener MR, Malińska , Rogoża E, Murawa D, Rudnicka H, Deptuła J, Lubiński

  • Cancer Res Treat.
  • 2019 Jan;51(1):337-344.
  • doi: 10.4143/crt.2018.157
PURPOSE: Germline mutations within melanoma susceptibility genes are present only in minority of melanoma patients and it is expected that additional genes will be discovered with next generation sequence technology...
Omitting Adjuvant Radiotherapy for Hormone Receptor‒Positive Early-Stage Breast Cancer in Old Age: A Propensity Score Matched SEER Analysis

Kim YJ, Shin KH, Kim K

  • Cancer Res Treat.
  • 2019 Jan;51(1):326-336.
  • doi: 10.4143/crt.2018.163
PURPOSE: The purpose of this study was to investigate the non-inferiority of omitting radiotherapy (RT) after breast-conserving surgery (BCS) for hormone receptor (HR)‒positive T1N0 breast cancer in elderly women. MATERIALS AND...
Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same

Sahu V, Nigam L, Agnihotri , Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S

  • Cancer Res Treat.
  • 2019 Jan;51(1):313-325.
  • doi: 10.4143/crt.2018.105
PURPOSE: The p38 mitogen-activated protein kinase (MAPKs) play a crucial role in the production of pro-inflammatory cytokines and over-expression of it increase cytokines which promote cancer. Among four isoforms, p38α...
Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma

Lim SM, Cho SH, Hwang IG, Choi JW, Chang H, Ahn MJ, Park KU, Kim JW, Ko YH, Ahn HK, Cho BC, Nam BH, Chun SH, Hong JH, Kwon JH, Choi JG, Kang EJ, Yun T, Lee KW, Kim JH, Kim JS, Lee HW, Kim MK, Jung D, Kim JE, Keam B, Yun HJ, Kim S, Kim HR

  • Cancer Res Treat.
  • 2019 Jan;51(1):300-312.
  • doi: 10.4143/crt.2018.012
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed to implement next-generation sequencing (NGS) in determining actionable...
Health-Related Quality of Life, Perceived Social Support, and Depression in Disease-Free Survivors Who Underwent Curative Surgery Only for Prostate, Kidney and Bladder Cancer: Comparison among Survivors and with the General Population

Shin DW, Park HS, Lee SH, Jeon SH, Cho S, Kang SH, Park SC, Park JH, Park J

  • Cancer Res Treat.
  • 2019 Jan;51(1):289-299.
  • doi: 10.4143/crt.2018.053
PURPOSE: The purpose of this study was to compare health-related quality of life (HRQoL) of disease-free prostate (PC), kidney (KC), and bladder cancer (BC) survivors with that of the general...
Different Patterns of Risk Reducing Decisions in Affected or Unaffected BRCA Pathogenic Variant Carriers

Lee EG, Kang HJ, Lim MC, Park B, Park SJ, Jung SY, Lee S, Kang HS, Park SY, Park B, Joo J, Han JH, Kong SY, Lee ES

  • Cancer Res Treat.
  • 2019 Jan;51(1):280-288.
  • doi: 10.4143/crt.2018.079
PURPOSE: The purpose of this study was to investigate decision patterns to reduce the risks of BRCArelated breast and gynecologic cancers in carriers of BRCA pathogenic variants. We found a...
Gastric Mucosal Atrophy Impedes Housekeeping Gene Methylation in Gastric Cancer Patients

Oh JH, Rhyu MG, Kim SI, Yun MR, Shin JH, Hong SJ

  • Cancer Res Treat.
  • 2019 Jan;51(1):267-279.
  • doi: 10.4143/crt.2018.085
PURPOSE: Helicobacter pylori infection induces phenotype-stabilizing methylation and promotes gastric mucosal atrophy that can inhibit CpG-island methylation. Relationship between the progression of gastric mucosal atrophy and the initiation of CpG-island...
Tumor-Associated Macrophages Derived TGF-β‒Induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells through Smad2,3-4/Snail Signaling Pathway

Cai J, Xia L, Li J, Ni S, Song H, Wu X

  • Cancer Res Treat.
  • 2019 Jan;51(1):252-266.
  • doi: 10.4143/crt.2017.613
PURPOSE: We investigated the role of tumor-associated macrophages (TAMs) on the epithelial to mesenchymal transition (EMT) of colorectal cancer cells and determined the potential mechanism involved in the metastatic process. MATERIALS...
The Comparison of Oncologic Outcomes between Open and Laparoscopic Radical Nephroureterectomy for the Treatment of Upper Tract Urothelial Carcinoma: A Korean Multicenter Collaborative Study

Kim TH, Hong B, Seo HK, Kang SH, Ku JH, Jeong BC

  • Cancer Res Treat.
  • 2019 Jan;51(1):240-251.
  • doi: 10.4143/crt.2017.417
PURPOSE: We compared oncologic outcomes of patients with upper tract urothelial carcinoma (UTUC) who underwent open nephroureterectomy (ONU) or laparoscopic nephroureterectomy (LNU). MATERIALS AND METHODS: Consecutive cases of ONU and LNU...
Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer

Kim JW, Kim JG, Kang BW, Chung IJ, Hong YS, Kim TY, Song HS, Lee KH, Zang DY, Ko YH, Song EK, Baek JH, Koo D, Oh SY, Cho H, Lee KW

  • Cancer Res Treat.
  • 2019 Jan;51(1):223-239.
  • doi: 10.4143/crt.2018.073
PURPOSE: The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric...
Landscape of Actionable Genetic Alterations Profiled from 1,071 Tumor Samples in Korean Cancer Patients

Lee SH, Lee B, Shim JH, Lee KW, Yun JW, Kim SY, Kim TY, Kim YH, Ko YH, Chung HC, Yu CS, Lee J, Rha SY, Kim TW, Jung KH, Im SA, Moon HG, Cho S, Kang JH, Kim J, Kim SK, Ryu HS, Ha SY, Kim JI, Chung YJ, Kim C, Kim HL, Park WY, Noh DY, Park K

  • Cancer Res Treat.
  • 2019 Jan;51(1):211-222.
  • doi: 10.4143/crt.2018.132
PURPOSE: With the emergence of next-generation sequencing (NGS) technology, profiling a wide range of genomic alterations has become a possibility resulting in improved implementation of targeted cancer therapy. In Asian...
Cancer-Associated Fibroblasts Promote the Chemo-resistance in Gastric Cancer through Secreting IL-11 Targeting JAK/STAT3/Bcl2 Pathway

Ma J, Song X, Xu X, Mou Y

  • Cancer Res Treat.
  • 2019 Jan;51(1):194-210.
  • doi: 10.4143/crt.2018.031
PURPOSE: Our aim was to detect the potential role of interleukin 11 (IL-11) in the development of chemo-resistance in gastric cancer and to reveal the mechanism involved in the process. MATERIALS...

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