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Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy

Hu Y, Wang J, Pu C, Zhao K, Cui Q, Wei G, Wu W, Xiao L, Xiao Y, Wang J, Wu Z, Huang H

  • Cancer Res Treat.
  • 2018 Oct;50(4):1462-1466.
  • doi: 10.4143/crt.2017.473
Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied....
Pembrolizumab for Refractory Metastatic Myxofibrosarcoma: A Case Report

Song HN, Kang MG, Park JR, Hwang JY, Kang JH, Lee WS, Lee GW

  • Cancer Res Treat.
  • 2018 Oct;50(4):1458-1461.
  • doi: 10.4143/crt.2017.529
Myxofibrosarcoma is a rare tumor, refractory to cytotoxic chemotherapy and radiotherapy. Pembrolizumab is an innovative immunotherapy drug consisting of programmed death receptor ligand 1 antibody proven to be useful for...
Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review

Zhu P, Duan Y, Ao Q, Wang G

  • Cancer Res Treat.
  • 2018 Oct;50(4):1452-1457.
  • doi: 10.4143/crt.2017.414
Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case...
Trends in Gallbladder Cancer Incidence and Survival in Korea

Wi Y, Woo H, Won YJ, Jang JY, Shin A

  • Cancer Res Treat.
  • 2018 Oct;50(4):1444-1451.
  • doi: 10.4143/crt.2017.279
PURPOSE: The current study was undertaken to examine the trend in gallbladder cancer (GBC) incidenceand survival in Korea. MATERIALS AND METHODS: GBC incidence data by histologic typewere obtained from the Korea...
The NEAT Predictive Model for Survival in Patients with Advanced Cancer

Zucker A, Tsai CJ, Loscalzo J, Calves P, Kao J

  • Cancer Res Treat.
  • 2018 Oct;50(4):1433-1443.
  • doi: 10.4143/crt.2017.223
PURPOSE: We previously developed a model to more accurately predict life expectancy for stage IV cancer patients referred to radiation oncology. The goals of this study are to validate this...
Negative Conversion of Progesterone Receptor Status after Primary Systemic Therapy Is Associated with Poor Clinical Outcome in Patients with Breast Cancer

Ahn S, Kim HJ, Kim M, Chung YR, Kang E, Kim EK, Kim SH, Kim YJ, Kim JH, Kim IA, Park SY

  • Cancer Res Treat.
  • 2018 Oct;50(4):1418-1432.
  • doi: 10.4143/crt.2017.552
PURPOSE: Alteration of biomarker status after primary systemic therapy (PST) is occasionally found in breast cancer. This study was conducted to clarify the clinical implications of change of biomarker status...
Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN

Liu T, Liu S, Xu Y, Shu R, Wang F, Chen C, Zeng Y, Luo H

  • Cancer Res Treat.
  • 2018 Oct;50(4):1396-1417.
  • doi: 10.4143/crt.2017.537
PURPOSE: This study aimed to probe into the associations among circular RNA ZFR (circ-ZFR), miR-130a/miR-107, and PTEN, and to investigate the regulatory mechanism of circ-ZFR–miR-130a/miR-107–PTEN axis in gastric cancer (GC). MATERIALS...
Projection of Breast Cancer Burden due to Reproductive/Lifestyle Changes in Korean Women (2013-2030) Using an Age-Period-Cohort Model

Lee JE, Lee SA, Kim TH, Park S, Choy YS, Ju YJ, Park EC

  • Cancer Res Treat.
  • 2018 Oct;50(4):1388-1395.
  • doi: 10.4143/crt.2017.162
PURPOSE: The aim of this study was to estimate the burden of breast cancer that can be attributed to rapid lifestyle changes in South Korea in 2013-2030. MATERIALS AND METHODS: An...
Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions

Lee SH, Kim JE, Jang HS, Park KH, Oh BH, Shin SJ, Chung KY, Roh MR, Rha SY

  • Cancer Res Treat.
  • 2018 Oct;50(4):1378-1387.
  • doi: 10.4143/crt.2017.535
PURPOSE: Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between...
Preclinical Study of Novel Curcumin Analogue SSC-5 Using Orthotopic Tumor Xenograft Model for Esophageal Squamous Cell Carcinoma

Tung LN, Song S, Chan KT, Choi MY, Lam HY, Chan CM, Chen Z, Wang HK, Leung HT, Law S, Huang Y, Song H, Lee NP

  • Cancer Res Treat.
  • 2018 Oct;50(4):1362-1377.
  • doi: 10.4143/crt.2017.353
PURPOSE: Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows...
Ligand-Independent Epidermal Growth Factor Receptor Overexpression Correlates with Poor Prognosis in Colorectal Cancer

Yun S, Kwak Y, Nam SK, Seo AN, Oh HK, Kim DW, Kang SB, Lee HS

  • Cancer Res Treat.
  • 2018 Oct;50(4):1351-1361.
  • doi: 10.4143/crt.2017.487
PURPOSE: Molecular treatments targeting epidermal growth factor receptors (EGFRs) are important strategies for advanced colorectal cancer (CRC). However, clinicopathologic implications of EGFRs and EGFR ligand signaling have not been fully...
Trends in Gastric Cancer Incidence According to the Clinicopathological Characteristics in Korea, 1999-2014

Eom BW, Jung KW, Won YJ, Yang H, Kim YW

  • Cancer Res Treat.
  • 2018 Oct;50(4):1343-1350.
  • doi: 10.4143/crt.2017.464
PURPOSE: The aim of this study was to evaluate recent trends in gastric cancer incidence according to the age, sex, and tumor location in the Korean population. MATERIALS AND METHODS: Using...
High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In vivo Compared with Monotherapy

Lee JE, Lim JH, Hong YK, Yang SH

  • Cancer Res Treat.
  • 2018 Oct;50(4):1331-1342.
  • doi: 10.4143/crt.2017.466
PURPOSE: The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in Vitro and in vivo. MATERIALS AND METHODS: We...
Multicenter Phase II Study of Oxaliplatin, Irinotecan, and S-1 as First-line Treatment for Patients with Recurrent or Metastatic Biliary Tract Cancer

Yoo C, Han B, Kim HS, Kim KP, Kim D, Jeong JH, Lee JL, Kim TW, Kim JH, Choi DR, Ha HI, Seo J, Chang HM, Ryoo BY, Zang DY

  • Cancer Res Treat.
  • 2018 Oct;50(4):1324-1330.
  • doi: 10.4143/crt.2017.526
PURPOSE: Although gemcitabine plus cisplatin has been established as the standard first-line chemotherapy for patients with advanced biliary tract cancer (BTC), overall prognosis remains poor. We investigated the efficacy of...
Breast Conservation Therapy Versus Mastectomy in Patients with T1-2N1 Triple-Negative Breast Cancer: Pooled Analysis of KROG 14-18 and 14-23

Kim K, Park HJ, Shin KH, Kim JH, Choi DH, Park W, Ahn SD, Kim SS, Kim DY, Kim TH, Kim JH, Kim J

  • Cancer Res Treat.
  • 2018 Oct;50(4):1316-1323.
  • doi: 10.4143/crt.2017.575
PURPOSE: The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) versus mastectomy for patients with pT1-2N1 triple-negative breast cancer (TNBC). MATERIALS...
Induction Chemotherapy Plus Concurrent Chemoradiotherapy Versus Concurrent Chemoradiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma in Children and Adolescents: A Matched Cohort Analysis

Li Y, Tang LQ, Liu LT, Guo SS, Liang YJ, Sun XS, Tang QN, Bei JX, Tan J, Chen S, Ma J, Zhao C, Chen QY, Mai HQ

  • Cancer Res Treat.
  • 2018 Oct;50(4):1304-1315.
  • doi: 10.4143/crt.2017.463
PURPOSE: The purpose of this study was to evaluate the long-term clinical outcome and toxicity of induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) compared with CCRT alone for the...
The Association of Acquired T790M Mutation with Clinical Characteristics after Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma

Huang YH, Hsu KH, Tseng JS, Chen KC, Hsu CH, Su KY, Chen JJ, Chen HW, Yu SL, Yang TY, Chang GC

  • Cancer Res Treat.
  • 2018 Oct;50(4):1294-1303.
  • doi: 10.4143/crt.2017.512
PURPOSE: The main objective of this study was to investigate the relationship among the clinical characteristics and the frequency of T790M mutation in advanced epidermal growth factor receptor (EGFR)–mutant lung...
Geographical Variations and Trends in Major Cancer Incidences throughout Korea during 1999-2013

Won YJ, Jung KW, Oh CM, Park EH, Kong HJ, Lee DH, Lee KH, The Community of Population-based Regional Cancer Registries

  • Cancer Res Treat.
  • 2018 Oct;50(4):1281-1293.
  • doi: 10.4143/crt.2017.411
PURPOSE: We aimed to describe the temporal trends and district-level geographical variations in cancer incidences throughout Korea during 1999-2013. MATERIALS AND METHODS: Data were obtained from the Korean National Cancer Incidence...
Factors Associated with Prolonged Patient-Attributable Delay in the Diagnosis of Colorectal Cancer

Zarcos-Pedrinaci I, Téllez T, Rivas-Ruiz F, Padilla-Ruiz MdC, Alcaide J, Rueda A, Baré ML, Suárez-Varela MMM, Briones E, Sarasqueta C, Fernández-Larrea N, Escobar A, Quintana J, Redondo M, For the REDISSEC-CARESS/CCR group

  • Cancer Res Treat.
  • 2018 Oct;50(4):1270-1280.
  • doi: 10.4143/crt.2017.371
PURPOSE: The delayed diagnosis of colorectal cancer (CRC) may be attributable to sociodemographic characteristics, to aspects of tumour histopathology or to the functioning of the health system. We seek to...
Score for the Survival Probability in Metastasis Breast Cancer: A Nomogram-Based Risk Assessment Model

Xiong Z, Deng G, Huang X, Li X, Xie X, Wang J, Shuang Z, Wang X

  • Cancer Res Treat.
  • 2018 Oct;50(4):1260-1269.
  • doi: 10.4143/crt.2017.443
PURPOSE: Survival of metastatic breast cancer (MBC) patient remains unknown and varies greatly from person to person. Thus, we aimed to construct a nomogram to quantify the survival probability of...

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