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The Impact of Surgical Timing on Pathologic Tumor Response after Short Course and Long Course Preoperative Chemoradiation for Locally Advanced Rectal Adenocarcinoma

Lee SW, Lee JH, Lee IK, Oh ST, Kim DY, Kim TH, Oh JH, Baek JY, Chang HJ, Park HC, Kim HC, Chie EK, Nam TK, Jang HS

  • Cancer Res Treat.
  • 2018 Jul;50(3):1039-1050.
  • doi: 10.4143/crt.2017.252
PURPOSE: A pooled analysis of multi-institutional trials was performed to analyze the effect of surgical timing on tumor response by comparing short course concurrent chemoradiotherapy (CCRT) with long course CCRT...
Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy

Lee SC, Kim KH, Kim OH, Lee SK, Hong HE, Choi BJ, Jeong W, Kim SJ

  • Cancer Res Treat.
  • 2018 Jul;50(3):1023-1038.
  • doi: 10.4143/crt.2017.085
PURPOSE: Everolimus only inhibits mammalian target of rapamycin complex 1 (mTORC1), whereas Ku0063794 inhibits both mTORC1 and mTORC2. Although they have similar anticancer effects, their combination has a synergistic effect...
Anti-SEMA3A Antibody: A Novel Therapeutic Agent to Suppress Glioblastoma Tumor Growth

Lee J, Shin YJ, Lee K, Cho HJ, Sa JK, Lee SY, Kim SH, Lee J, Yoon Y, Nam DH

  • Cancer Res Treat.
  • 2018 Jul;50(3):1009-1022.
  • doi: 10.4143/crt.2017.315
PURPOSE: Glioblastoma (GBM) is classified as one of the most aggressive and lethal brain tumor. Great strides have been made in understanding the genomic and molecular underpinnings of GBM, which...
Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939-Mediated Transcriptional Repression of Bcl-xL

Cui C, Zhai D, Cai L, Duan Q, Xie L, Yu J

  • Cancer Res Treat.
  • 2018 Jul;50(3):992-1008.
  • doi: 10.4143/crt.2017.226
PURPOSE: Studies have found that long noncoding RNA HEIH (lncRNA-HEIH) is upregulated and facilitates hepatocellular carcinoma tumor growth. However, its clinical significances, roles, and action mechanism in colorectal cancer (CRC)...
Effects of Aspirin, Nonsteroidal Anti-inflammatory Drugs, Statin, and COX2 Inhibitor on the Developments of Urological Malignancies: A Population-Based Study with 10-Year Follow-up Data in Korea

Kang M, Ku JH, Kwak C, Kim HH, Jeong CW

  • Cancer Res Treat.
  • 2018 Jul;50(3):984-991.
  • doi: 10.4143/crt.2017.248
PURPOSE: The purpose of this study was to determine the impact of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), statin, and cyclooxygenase 2 (COX-2) inhibitor on the development of kidney, prostate, and...
Patterns of Rectal Cancer Radiotherapy Adopting Evidence-Based Medicine: An Analysis of the National Database from 2005 to 2016

Park HJ, Cho S, Kim Y

  • Cancer Res Treat.
  • 2018 Jul;50(3):975-983.
  • doi: 10.4143/crt.2017.459
PURPOSE: Not many studies have evaluated the adoption and dissemination of evidence-based medicine in rectal cancer radiotherapy (RT). We aimed to analyze the differences by institutional characteristics and geography in...
The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)

Kwon J, Eom KY, Kim YS, Park W, Chun M, Lee J, Kim YB, Yoon WS, Kim JH, Choi JH, Chang SK, Jeong BK, Lee SH, Cha J

  • Cancer Res Treat.
  • 2018 Jul;50(3):964-974.
  • doi: 10.4143/crt.2017.346
PURPOSE: We aimed to assess prognostic value of metastatic pelvic lymph node (mPLN) in early-stage cervical cancer treated with radical surgery followed by postoperative chemoradiotherapy. Also, we sought to define...
Comparison of Clinical Features and Outcomes in Epithelial Ovarian Cancer according to Tumorigenicity in Patient-Derived Xenograft Models

Eoh KJ, Chung YS, Lee SH, Park SA, Kim HJ, Yang W, Lee IO, Lee JY, Cho H, Chay DB, Kim S, Kim SW, Kim JH, Kim YT, Nam EJ

  • Cancer Res Treat.
  • 2018 Jul;50(3):956-963.
  • doi: 10.4143/crt.2017.181
PURPOSE: Although the use of xenograft models is increasing, few studies have compared the clinical features or outcomes of epithelial ovarian cancer (EOC) patients according to the tumorigenicity of engrafted...
Utility of the National Lung Screening Trial Criteria for Estimation of Lung Cancer in the Korean Population

Lee YJ, Choi SM, Lee J, Lee CH, Lee SM, Yoo CG, Kim YW, Han SK, Park YS

  • Cancer Res Treat.
  • 2018 Jul;50(3):950-955.
  • doi: 10.4143/crt.2017.357
PURPOSE: Screening forlung cancerin high-risk patients using the National Lung Screening Trial (NLST) criteria resulted in a decreased lung cancer-related mortality rate. However, whether these criteria are applicable to the...
MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line

Wang L, Qu J, Zhou L, Liao F, Wang J

  • Cancer Res Treat.
  • 2018 Jul;50(3):936-949.
  • doi: 10.4143/crt.2017.302
PURPOSE: The purpose of this study was to investigate the biological role and mechanism of miR-373 targeting of TFIIB-related factor 2 (BRF2) in the regulation of non-small cell lung cancer...
Clinical Risk Factors Influencing Dental Developmental Disturbances in Childhood Cancer Survivors

Kang CM, Hahn SM, Kim HS, Lyu CJ, Lee JH, Lee J, Han JW

  • Cancer Res Treat.
  • 2018 Jul;50(3):926-935.
  • doi: 10.4143/crt.2017.296
PURPOSE: Although studies regarding dental developmental disturbances after childhood cancer treatment have increased, they have many limitations. Studies analyzing the significance of independent clinical risk factors with regard to the...
Detection of Germline Mutations in Patients with Epithelial Ovarian Cancer Using Multi-gene Panels: Beyond BRCA1/2

Eoh KJ, Kim JE, Park HS, Lee ST, Park JS, Han JW, Lee JY, Kim S, Kim SW, Kim JH, Kim YT, Nam EJ

  • Cancer Res Treat.
  • 2018 Jul;50(3):917-925.
  • doi: 10.4143/crt.2017.220
PURPOSE: Next-generation sequencing (NGS) allows simultaneous sequencing of multiple cancer susceptibility genes and may represent a more efficient and less expensive approach than sequential testing. We assessed the frequency of...
EGFR Mutation Status in Lung Adenocarcinoma-Associated Malignant Pleural Effusion and Efficacy of EGFR Tyrosine Kinase Inhibitors

Yang J, Lee OJ, Son SM, Woo CG, Jeong Y, Yang Y, Kwon J, Lee KH, Han HS

  • Cancer Res Treat.
  • 2018 Jul;50(3):908-916.
  • doi: 10.4143/crt.2017.378
PURPOSE: Malignant pleural effusions (MPEs) are often observed in lung cancer, particularly adenocarcinoma. The aim of this study was to investigate epidermal growth factor receptor (EGFR) mutation status in lung...
Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance

Li Z, Chan K, Qi Y, Lu L, Ning F, Wu M, Wang H, Wang Y, Cai S, Du J

  • Cancer Res Treat.
  • 2018 Jul;50(3):894-907.
  • doi: 10.4143/crt.2017.356
PURPOSE: Cancer-associated fibroblasts (CAFs) activated by cancer cells has a central role in development and malignant biological behavior in colorectal cancer (CRC). Adult fibroblasts do not express Snail, but Snail-positive...
Profiling of Serum Metabolites Using MALDI-TOF and Triple-TOF Mass Spectrometry to Develop a Screen for Ovarian Cancer

Lee JH, Kim YH, Kim KH, Cho JY, Woo SM, Yoo BC, Kim SC

  • Cancer Res Treat.
  • 2018 Jul;50(3):883-893.
  • doi: 10.4143/crt.2017.275
PURPOSE: We sought to develop a matrix assisted laser desorption ionization-time of flight (MALDI-TOF)-based, ovarian cancer (OVC), low-mass-ion discriminant equation (LOME) and to evaluate a possible supportive role for triple-TOF...
NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia

Yi ES, Choi YB, Choi R, Lee NH, Lee JW, Yoo KH, Sung KW, Lee SY, Koo HH

  • Cancer Res Treat.
  • 2018 Jul;50(3):872-882.
  • doi: 10.4143/crt.2017.283
PURPOSE: We aimed to identify the impact of NUDT15 variants on thiopurine intolerance and 6-thioguanine nucleotide (6-TGN) levels in Korean children with acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: Genotyping of...
Combination of Tumor Volume and Epstein-Barr Virus DNA Improved Prognostic Stratification of Stage II Nasopharyngeal Carcinoma in the Intensity Modulated Radiotherapy Era: A Large-Scale Cohort Study

Chen QY, Guo SY, Tang LQ, Lu TY, Chen BL, Zhong QY, Zou MS, Tang QN, Chen WH, Guo SS, Liu LT, Li Y, Guo L, Mo HY, Sun R, Luo DH, Zhao C, Cao KJ, Qian CN, Guo X, Zeng MS, Mai HQ

  • Cancer Res Treat.
  • 2018 Jul;50(3):861-871.
  • doi: 10.4143/crt.2017.237
PURPOSE: Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy...
Impact of Body Mass Index on the Quality of Life after Total Gastrectomy for Gastric Cancer

Park KB, Park JY, Lee SS, Kwon OK, Chung HY, Yu W

  • Cancer Res Treat.
  • 2018 Jul;50(3):852-860.
  • doi: 10.4143/crt.2017.080
PURPOSE: We evaluated the impact of postoperative body mass index (BMI) shifts on the quality of life (QoL) following total gastrectomy in patients with gastric cancer. MATERIALS AND METHODS: QoL data...
Sarcopenia Predicts Prognosis in Patients with Newly Diagnosed Hepatocellular Carcinoma, Independent of Tumor Stage and Liver Function

Ha Y, Kim D, Han S, Chon YE, Lee YB, Kim MN, Lee JH, Park H, Rim KS, Hwang SG

  • Cancer Res Treat.
  • 2018 Jul;50(3):843-851.
  • doi: 10.4143/crt.2017.232
PURPOSE: The purpose of this study was to demonstrate the prognostic significance of changes in body composition in patients with newly diagnosed hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Patients (n=178) newly...
Phase 1 Studies of Poziotinib, an Irreversible Pan-HER Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

Kim TM, Lee KW, Oh DY, Lee JS, Im SA, Kim DW, Han SW, Kim YJ, Kim TY, Kim JH, Han H, Kim WH, Bang YJ

  • Cancer Res Treat.
  • 2018 Jul;50(3):835-842.
  • doi: 10.4143/crt.2017.303
PURPOSE: Poziotinib, a pan-human epidermal growth factor receptor 2 (HER) tyrosine kinase inhibitor, has shown potent activity againstwild type of epidermal growth factorreceptor(EGFR) family kinases including EGFR, HER2, and HER4...

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