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Experiences and Opinions Related to End-of-Life Discussion: From Oncologists' and Resident Physicians' Perspectives

Koh SJ, Kim S, Kim J, Keam B, Heo DS, Lee KH, Kim BS, Kim JH, Chang HJ, Baek SK

  • Cancer Res Treat.
  • 2018 Apr;50(2):614-623.
  • doi: 10.4143/crt.2016.446
PURPOSE: The aims of this study were to explore how oncologists and resident physicians practice end-of-life (EOL) discussions and to solicit their opinions on EOL discussions as a means to...
Crizotinib in Combination with Everolimus Synergistically Inhibits Proliferation of Anaplastic Lymphoma Kinase‒Positive Anaplastic Large Cell Lymphoma

Xu W, Kim JW, Jung WJ, Koh Y, Yoon SS

  • Cancer Res Treat.
  • 2018 Apr;50(2):599-613.
  • doi: 10.4143/crt.2016.357
PURPOSE: Anaplastic large cell lymphoma (ALCL) is a rare aggresive non-Hodgkin lymphoma, of which over 50% of cases have an aberrant nucleophosmin (NPM)‒anaplastic lymphoma kinase (ALK) fusion protein. Both mechanistic...
Multicenter Retrospective Analysis of Clinical Characteristics, Treatment Patterns, and Outcomes in Very Elderly Patients with Diffuse Large B-Cell Lymphoma: The Korean Cancer Study Group LY16-01

Choi JH, Kim TM, Kim HJ, Koh SA, Mun YC, Kang HJ, Jung YH, Shim H, Chong SY, Sun DS, Lee S, Park BB, Kwon JH, Nam SH, Yi JH, Yuh YJ, Jin JY, Han JJ, Kim SH

  • Cancer Res Treat.
  • 2018 Apr;50(2):590-598.
  • doi: 10.4143/crt.2017.172
PURPOSE: The treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor treatment tolerability and lack of data. MATERIALS...
Effectiveness of Gastric Cancer Screening on Gastric Cancer Incidence and Mortality in a Community-Based Prospective Cohort

Kim H, Hwang Y, Sung H, Jang J, Ahn C, Kim SG, Yoo KY, Park SK

  • Cancer Res Treat.
  • 2018 Apr;50(2):582-589.
  • doi: 10.4143/crt.2017.048
PURPOSE: This study was performed to investigate the effectiveness of gastric cancer (GC) screening methods in a community-based prospective cohort of the Korean Multi-center Cancer Cohort (KMCC) with over a...
Low-Dose Radiation Therapy for Primary Conjunctival Marginal Zone B-Cell Lymphoma

Lee GI, Oh D, Kim WS, Kim SJ, Ko YH, Woo KI, Kim YD, Ahn YC

  • Cancer Res Treat.
  • 2018 Apr;50(2):575-581.
  • doi: 10.4143/crt.2017.182
PURPOSE: The purpose of this study was to evaluate the clinical features and the long-term outcomes of primary conjunctival marginal zone B-cell lymphoma (MZBCL) patients who were treated with radiation...
The Role of Consolidation Chemoradiotherapy in Locally Advanced Pancreatic Cancer Receiving Chemotherapy: An Updated Systematic Review and Meta-Analysis

Chang JS, Chiu YF, Yu JC, Chen LT, Ch'ang HJ

  • Cancer Res Treat.
  • 2018 Apr;50(2):562-574.
  • doi: 10.4143/crt.2017.105
PURPOSE: The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using...
Evaluation of the Benefit of Radiotherapy in Patients with Occult Breast Cancer: A Population-Based Analysis of the SEER Database

Kim BH, Kwon J, Kim K

  • Cancer Res Treat.
  • 2018 Apr;50(2):551-561.
  • doi: 10.4143/crt.2017.189
PURPOSE: Few studies for occult breast cancer (OBC) have evaluated the effect of radiotherapy (RT) after mastectomy or axillary lymph node dissection (ALND) with/without breast surgery. Therefore, we investigated clinicopathologic...
Declined Preoperative Aspartate Aminotransferase to Neutrophil Ratio Index Predicts Poor Prognosis in Patients with Intrahepatic Cholangiocarcinoma after Hepatectomy

Liu L, Wang W, Zhang Y, Long J, Zhang Z, Li Q, Chen B, Li S, Hua Y, Shen S, Peng B

  • Cancer Res Treat.
  • 2018 Apr;50(2):538-550.
  • doi: 10.4143/crt.2017.106
PURPOSE: Various inflammation-based prognostic biomarkers such as the platelet to lymphocyte ratio and neutrophil to lymphocyte ratio, are related to poor survival in patients with intrahepatic cholangiocarcinoma (ICC). This study...
Body Composition Predicts Survival in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization

Parikh ND, Zhang P, Singal AG, Derstine B, Krishnamurthy V, Barman P, Waljee AK, Su GL

  • Cancer Res Treat.
  • 2018 Apr;50(2):530-537.
  • doi: 10.4143/crt.2017.156
PURPOSE: The prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) is often uncertain. We aimed to utilize analytic morphomics, a high-throughput imaging analysis, to assess if body...
Phase II Study of Induction Chemotherapy with Docetaxel, Capecitabine, and Cisplatin Plus Bevacizumab for Initially Unresectable Gastric Cancer with Invasion of Adjacent Organs or Paraaortic Lymph Node Metastasis

Kim JH, Park SR, Ryu MH, Ryoo BY, Kim KP, Kim BS, Yoo MW, Yook JH, Kim BS, Kim J, Byeon SJ, Kang YK

  • Cancer Res Treat.
  • 2018 Apr;50(2):518-529.
  • doi: 10.4143/crt.2017.005
PURPOSE: The purpose of this study was to evaluate the efficacy and safety of induction chemotherapy with docetaxel, capecitabine, and cisplatin (DXP) plus bevacizumab (BEV) on initially unresectable locally advanced...
Redefining the Positive Circumferential Resection Margin by Incorporating Preoperative Chemoradiotherapy Treatment Response in Locally Advanced Rectal Cancer: A Multicenter Validation Study

Lee JH, Chie EK, Jeong SY, Kim TY, Kim DY, Kim TH, Kim SY, Baek JY, Chang HJ, Kim MJ, Park SC, Oh JH, Kim SH, Lee JH, Choi DH, Park HC, Kang SB, Kim JS

  • Cancer Res Treat.
  • 2018 Apr;50(2):506-517.
  • doi: 10.4143/crt.2016.607
PURPOSE: This study was conducted to validate the prognostic influence of treatment response among patients with positive circumferential resection margin for locally advanced rectal cancer. MATERIALS AND METHODS: Clinical data of...
ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor

Lee JW, Park SH, Kang HJ, Park KD, Shin HY, Ahn HS

  • Cancer Res Treat.
  • 2018 Apr;50(2):495-505.
  • doi: 10.4143/crt.2016.577
PURPOSE: In this study, anaplastic lymphoma kinase (ALK) mutation and amplification, ALK protein expression, loss of the nuclear alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein, and telomerase reverse transcriptase (TERT)...
Pazopanib for the Treatment of Non-clear Cell Renal Cell Carcinoma: A Single-Arm, Open-Label, Multicenter, Phase II Study

Jung KS, Lee SJ, Park SH, Lee JL, Lee SH, Lim JY, Kang JH, Lee S, Rha SY, Lee KH, Kim HY, Lim HY

  • Cancer Res Treat.
  • 2018 Apr;50(2):488-494.
  • doi: 10.4143/crt.2016.584
PURPOSE: The optimal treatment strategy for patients with metastatic non-clear cell type renal cell carcinoma (nccRCC) remains unclear. Although several inhibitors of vascular endothelial growth factor have recently shown efficacy...
Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies

Choi YJ, Myung SK, Lee JH

  • Cancer Res Treat.
  • 2018 Apr;50(2):474-487.
  • doi: 10.4143/crt.2017.094
PURPOSE: The purpose of this study was to determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015...
Molecular Signature for Lymphatic Invasion Associated with Survival of Epithelial Ovarian Cancer

Paik ES, Choi HJ, Kim TJ, Lee JW, Kim BG, Bae DS, Choi CH

  • Cancer Res Treat.
  • 2018 Apr;50(2):461-473.
  • doi: 10.4143/crt.2017.104
PURPOSE: We aimed to develop molecular classifier that can predict lymphatic invasion and their clinical significance in epithelial ovarian cancer (EOC) patients. MATERIALS AND METHODS: We analyzed gene expression (mRNA, methylated...
Ferroptosis: A Novel Anti-tumor Action for Cisplatin

Guo J, Xu B, Han Q, Zhou H, Xia Y, Gong C, Dai X, Li Z, Wu G

  • Cancer Res Treat.
  • 2018 Apr;50(2):445-460.
  • doi: 10.4143/crt.2016.572
PURPOSE: Ferroptosis is a new mode of regulated cell death, which is completely distinct from other cell death modes based on morphological, biochemical, and genetic criteria. This study evaluated the...
Awareness of and Attitudes toward Human Papillomavirus Vaccination among Adults in Korea: 9-Year Changes in Nationwide Surveys

Oh JK, Jeong BY, Yun EH, Lim MK

  • Cancer Res Treat.
  • 2018 Apr;50(2):436-444.
  • doi: 10.4143/crt.2017.174
PURPOSE: Human papillomavirus (HPV) vaccination has been included in the National Immunization Program in Korea since 2016. We aimed to evaluate changes in the awareness of and attitudes toward HPV...
Risk of Second Primary Cancer in People with Non-melanoma Skin Cancer: A Nationwide Cohort Study

Wang SH, Chi CC, Zhao ZH, Tung TH

  • Cancer Res Treat.
  • 2018 Apr;50(2):428-435.
  • doi: 10.4143/crt.2017.110
PURPOSE: Previous western studies have found Caucasians with skin cancer, either melanoma or nonmelanoma skin cancer (NMSC), have an elevated risk of second primary cancer. Our objective was to assess...
Stages of Adoption for Fecal Occult Blood Test and Colonoscopy Tests for Colorectal Cancer Screening in Korea

Bui NC, Cho HN, Lee YY, Suh M, Park B, Jun JK, Kim Y, Choi KS

  • Cancer Res Treat.
  • 2018 Apr;50(2):416-427.
  • doi: 10.4143/crt.2017.075
PURPOSE: While colorectal cancer (CRC) is common in Asian countries, screening for CRC is not. Moreover, CRC screening behaviors in Asian populations remain largely unknown. The present study aimed to...
Development and Evaluation of a Korean Version of a Thyroid-Specific Quality-of-Life Questionnaire Scale in Thyroid Cancer Patients

Ryu CH, Park B, Ryu J, Ryu YM, Jo SA, Lee YJ, Lee EK, Hwangbo Y, Joo J, Jung YS

  • Cancer Res Treat.
  • 2018 Apr;50(2):405-415.
  • doi: 10.4143/crt.2017.012
PURPOSE: The purpose of this study was to develop a Korean version of the self-reported thyroid-specific quality of life (QoL) questionnaire for thyroid cancer patients (KT-QoL), and to evaluate its...

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