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Practice Patterns Regarding Multidisciplinary Cancer Management and Suggestions for Further Refinement: Results from a National Survey in Korea

Lee YG, Oh S, Kimm H, Koo DH, Kim DY, Kim BS, Lee SS

  • Cancer Res Treat.
  • 2017 Oct;49(4):1164-1169.
  • doi: 10.4143/crt.2016.517
PURPOSE: This study was conducted to explore the process and operation of a cancer multidisciplinary team (MDT) after the reimbursement decision in Korea, and to identify ways to overcome the...
Bilateral Salpingo-oophorectomy Compared to Gonadotropin-Releasing Hormone Agonists in Premenopausal Hormone Receptor?Positive Metastatic Breast Cancer Patients Treated with Aromatase Inhibitors

Suh KJ, Kim SH, Lee KH, Kim TY, Kim YJ, Han SW, Kang E, Kim EK, Kim K, No JH, Han W, Noh DY, Lee M, Kim HS, Im SA, Kim JH

  • Cancer Res Treat.
  • 2017 Oct;49(4):1153-1163.
  • doi: 10.4143/crt.2016.463
PURPOSE: Although combining aromatase inhibitors (AI) with gonadotropin-releasing hormone agonists (GnRHa) is becoming more common, it is still not clear if GnRHa is as effective as bilateral salpingo-oophorectomy (BSO). MATERIALS AND...
Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity

Schmohl JU, Felices M, Oh F, Lenvik AJ, Lebeau AM, Panyam J, Miller JS, Vallera DA

  • Cancer Res Treat.
  • 2017 Oct;49(4):1140-1152.
  • doi: 10.4143/crt.2016.491
PURPOSE: The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform,...
Prognostic Factors and Scoring Model for Survival in Metastatic Biliary Tract Cancer

Park HS, Park JS, Chun YJ, Roh YH, Moon J, Chon HJ, Choi HJ, Park JS, Lee DK, Lee SJ, Yoon DS, Jeung HC

  • Cancer Res Treat.
  • 2017 Oct;49(4):1127-1139.
  • doi: 10.4143/crt.2016.538
PURPOSE: Metastatic biliary tract cancer (mBTC) has a dismal prognosis. In this study, an independent dataset of patients with mBTC was used to implement and validate a routine clinico-laboratory parameter-based...
Education Level Is a Strong Prognosticator in the Subgroup Aged More Than 50 Years Regardless of the Molecular Subtype of Breast Cancer: A Study Based on the Nationwide Korean Breast Cancer Registry Database

Hwang KT, Noh W, Cho SH, Yu J, Park MH, Jeong J, Lee HJ, Kim J, Oh S, Kim YA, Korean Breast Cancer Society

  • Cancer Res Treat.
  • 2017 Oct;49(4):1114-1126.
  • doi: 10.4143/crt.2016.528
PURPOSE: This study investigated the role of the education level (EL) as a prognostic factor for breast cancer and analyzed the relationship between the EL and various confounding factors. MATERIALS AND...
Survival of Cancer Patients in Northeast China: Analysis of Sampled Cancers from Population-Based Cancer Registries

Li Y, Yu L, Na J, Li S, Liu L, Mu H, Bi X, An X, Li X, Dong W, Pan G

  • Cancer Res Treat.
  • 2017 Oct;49(4):1106-1113.
  • doi: 10.4143/crt.2016.613
PURPOSE: The cancer survival was characterized by following up sampled subgroups of cancer cases from three population-based cancer registries in Northeast China. MATERIALS AND METHODS: Survival analysis was used to analyze...
Comparison of the Clinical Outcomes of Patients with Squamous Cell Carcinoma of the Tonsil Receiving Postoperative Ipsilateral Versus Bilateral Neck Radiotherapy: A Propensity Score Matching Analysis (KROG 11-07)

Kim Y, Cho KH, Moon SH, Lee CG, Keum KC, Lee SW, Ahn YC, Oh D, Kim YS, Won YK, Wu HG, Hah JH, Oh YT

  • Cancer Res Treat.
  • 2017 Oct;49(4):1097-1105.
  • doi: 10.4143/crt.2016.425
PURPOSE: The impact of postoperative ipsilateral neck radiotherapy (INRT) versus bilateral neck radiotherapy (BNRT) on the clinical outcomes of patients with tonsillar squamous cell carcinoma was analyzed retrospectively. MATERIALS AND METHODS:...
Can We Skip Intraoperative Evaluation of Sentinel Lymph Nodes? Nomogram Predicting Involvement of Three or More Axillary Lymph Nodes before Breast Cancer Surgery

Ahn SK, Kim MK, Kim J, Lee E, Yoo TK, Lee HB, Kang YJ, Kim J, Moon HG, Chang JM, Cho N, Moon WK, Park IA, Noh DY, Han W

  • Cancer Res Treat.
  • 2017 Oct;49(4):1088-1096.
  • doi: 10.4143/crt.2016.473
PURPOSE: The American College of Surgeons Oncology Group Z0011 trial reported that complete dissection of axillary lymph nodes (ALNs) may not be warranted in women with clinical T1-T2 tumors and...
Identification of Diverse Adenosine-to-Inosine RNA Editing Subtypes in Colorectal Cancer

Lee SH, Kim HP, Kang JK, Song SH, Han SW, Kim TY

  • Cancer Res Treat.
  • 2017 Oct;49(4):1077-1087.
  • doi: 10.4143/crt.2016.301
PURPOSE: RNA editing generates protein diversity by altering RNA sequences in coding regions without changing the overall DNA sequence. Adenosine-to-inosine (A-to-I) RNA editing events have recently been reported in some...
Prevalence of Mutations in Discoidin Domain-Containing Receptor Tyrosine Kinase 2 (DDR2) in Squamous Cell Lung Cancers in Korean Patients

Lee MS, Jung EA, An SB, Kim YJ, Oh DY, Song JY, Um SW, Han J, Choi YL

  • Cancer Res Treat.
  • 2017 Oct;49(4):1065-1076.
  • doi: 10.4143/crt.2016.347
PURPOSE: The discoidin domain-containing receptor tyrosine kinase 2 (DDR2) is known to contain mutations in a small subset of patients with squamous cell carcinomas (SCC) of the lung. Studying the...
Gonadal and Sexual Dysfunction in Childhood Cancer Survivors

Yoon JY, Park HJ, Ju HY, Yoon JH, Chung JS, Hwang SH, Lee DO, Shim HY, Park BK

  • Cancer Res Treat.
  • 2017 Oct;49(4):1057-1064.
  • doi: 10.4143/crt.2016.197
PURPOSE: Few studies have addressed gonadal and sexual dysfunctions in childhood cancer survivors. We evaluated the prevalence rates and risk factors for gonadal failure among adolescent/young adult childhood cancer survivors...
Effects of Soy Product Intake and Interleukin Genetic Polymorphisms on Early Gastric Cancer Risk in Korea: A Case-Control Study

Yang S, Park Y, Lee J, Choi IJ, Kim YW, Ryu KW, Sung J, Kim J

  • Cancer Res Treat.
  • 2017 Oct;49(4):1044-1056.
  • doi: 10.4143/crt.2016.515
PURPOSE: The current study investigated whether the combined effects of soy intake and genetic polymorphisms of interleukin (IL) genes modify gastric cancer risk. MATERIALS AND METHODS: A total of 377 cases...
Korean Cancer Patients' Awareness of Clinical Trials, Perceptions on the Benefit and Willingness to Participate

Lim Y, Lim JM, Jeong WJ, Lee KH, Keam B, Kim TY, Kim TM, Han SW, Oh DY, Kim DW, Kim TY, Heo DS, Bang YJ, Im SA

  • Cancer Res Treat.
  • 2017 Oct;49(4):1033-1043.
  • doi: 10.4143/crt.2016.413
PURPOSE: The purpose of this study was to assess current levels of awareness of clinical trials (CTs), perceptions regarding their benefits and willingness to participate to CTs among Korean cancer...
Induction Chemotherapy with Gemcitabine and Cisplatin Followed by Simultaneous Integrated Boost–Intensity Modulated Radiotherapy with Concurrent Gemcitabine for Locally Advanced Unresectable Pancreatic Cancer: Results from a Feasibility Study

Woo SM, Kim MK, Joo J, Yoon KA, Park B, Park SJ, Han SS, Lee JH, Hong EK, Kim YH, Moon H, Kong SY, Kim TH, Lee WJ

  • Cancer Res Treat.
  • 2017 Oct;49(4):1022-1032.
  • doi: 10.4143/crt.2016.495
PURPOSE: This study assessed the feasibility and compliance of induction chemotherapy with gemcitabine and cisplatin followed by simultaneous integrated boost–intensity modulated radiotherapy (SIB-IMRT) with concurrent gemcitabine in patients with locally...
Identification of a Novel BRCA1 Pathogenic Mutation in Korean Patients Following Reclassification of BRCA1 and BRCA2 Variants According to the ACMG Standards and Guidelines Using Relevant Ethnic Controls

Park JS, Nam EJ, Park HS, Han JW, Lee JY, Kim J, Kim TI, Lee ST

  • Cancer Res Treat.
  • 2017 Oct;49(4):1012-1021.
  • doi: 10.4143/crt.2016.433
PURPOSE: Comparison of variant frequencies in the general population has become an essential part of the American College of Medical Genetics and Genomics (ACMG) standards and guidelines for interpreting sequence...
Randomized Phase II Study of Afatinib Plus Simvastatin Versus Afatinib Alone in Previously Treated Patients with Advanced Nonadenocarcinomatous Non-small Cell Lung Cancer

Lee Y, Lee KH, Lee GK, Lee SH, Lim KY, Joo J, Go YJ, Lee JS, Han JY

  • Cancer Res Treat.
  • 2017 Oct;49(4):1001-1011.
  • doi: 10.4143/crt.2016.546
PURPOSE: This phase II study examined whether the addition of simvastatin to afatinib provides a clinical benefit compared with afatinib monotherapy in previously treated patients with nonadenocarcinomatous non-small cell lung...
Risk Factors of Female Breast Cancer in Vietnam: A Case-Control Study

Trieu PD, Mello-Thoms C, Peat JK, Do TD, Brennan PC

  • Cancer Res Treat.
  • 2017 Oct;49(4):990-1000.
  • doi: 10.4143/crt.2016.488
PURPOSE: Rates of women with breast cancer have increased rapidly in recent years in Vietnam, with over 10,000 new patients contracting the disease every year. This study was conducted to...
Incorporating Erlotinib or Irinotecan Plus Cisplatin into Chemoradiotherapy for Stage III Non-small Cell Lung Cancer According to EGFR Mutation Status

Lee Y, Han JY, Moon SH, Nam BH, Lim KY, Lee GK, Kim HT, Yun T, An HJ, Lee JS

  • Cancer Res Treat.
  • 2017 Oct;49(4):981-989.
  • doi: 10.4143/crt.2016.522
PURPOSE: Concurrent chemoradiotherapy (CCRT) is the standard care for stage III non-small cell lung cancer (NSCLC) patients; however, a more effective regimen is needed to improve the outcome by better...
Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline Plus Taxane-Based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study

Kim H, Park W, Yu JI, Choi DH, Huh SJ, Kim YJ, Lee ES, Lee KS, Kang HS, Park IH, Shin KH, Wee CW, Kim K, Park KR, Kim YB, Ahn SJ, Lee JH, Kim JH, Chun M, Lee HS, Kim JS, Cha J

  • Cancer Res Treat.
  • 2017 Oct;49(4):970-980.
  • doi: 10.4143/crt.2016.382
PURPOSE: This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT)...
Neurocognitive and Psychological Functioning of Children with an Intracranial Germ Cell Tumor

Park Y, Yu ES, Ha B, Park HJ, Kim JH, Kim JY

  • Cancer Res Treat.
  • 2017 Oct;49(4):960-969.
  • doi: 10.4143/crt.2016.204
PURPOSE: This study was conducted to investigate the neurocognitive functioning of children with intracranial germ cell tumor (IGCT) prior to receiving proton beam therapy (PBT), and to identify differential characteristics...

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