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Erdheim-Chester Disease with Emperipolesis: A Unique Case Involving the Heart

Zhu P, Li N, Yu L, Miranda MN, Wang G, Duan Y

  • Cancer Res Treat.
  • 2017 Apr;49(2):553-558.
  • doi: 10.4143/crt.2016.078
Histiocytosis is an uncommon disease characterized by excessive accumulation of histiocytes. Here, we report a rare case of non-Langerhans-cell histiocytosis in a 51-year-old woman who presented with severe symptoms of...
Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia

Lutz M, Schulze AB, Rebber E, Wiebe S, Zoubi T, Grauer OM, Keßler T, Kerkhoff A, Lenz G, Berdel WE

  • Cancer Res Treat.
  • 2017 Apr;49(2):548-552.
  • doi: 10.4143/crt.2016.110
Progressive multifocal leukoencephalopathy (PML) is a devastating neurological disease observed nearly exclusively in immunocompromised patients. Recently, the introduction of monoclonal antibodies significantly inhibiting the immune system such as rituximab has...
Alcohol Intake and Risk of Thyroid Cancer: A Meta-Analysis of Observational Studies

Hong SH, Myung SK, Kim HS, The Korean Meta-Analysis (KORMA) Study Group

  • Cancer Res Treat.
  • 2017 Apr;49(2):534-547.
  • doi: 10.4143/crt.2016.161
PURPOSE: The purpose of this study was to assess whether alcohol intake is associated with the risk of thyroid cancer by a meta-analysis of observational studies. MATERIALS AND METHODS: We searched...
Trends and Age-Period-Cohort Effects on the Incidence and Mortality Rate of Cervical Cancer in Korea

Moon EK, Oh CM, Won YJ, Lee JK, Jung KW, Cho H, Jun JK, Lim MC, Ki M

  • Cancer Res Treat.
  • 2017 Apr;49(2):526-533.
  • doi: 10.4143/crt.2016.316
PURPOSE: This study was conducted to describe the trends and age-period-cohort effects on the incidence and mortality rate of cervical cancer in Korea. MATERIALS AND METHODS: The incidence and mortality rate...
Magnetic Resonance Imaging–Detected Intracranial Extension in the T4 Classification Nasopharyngeal Carcinoma with Intensity-Modulated Radiotherapy

Cao C, Luo J, Gao L, Yi J, Huang X, Li S, Xiao J, Zhang Z, Xu G

  • Cancer Res Treat.
  • 2017 Apr;49(2):518-525.
  • doi: 10.4143/crt.2016.299
PURPOSE: This study was conducted is to identify the prognostic value and staging categories of magnetic resonance imaging (MRI)–detected intracranial extension in nasopharyngeal carcinoma (NPC) with intensity-modulated radiotherapy (IMRT) to...
The Role of Notch1 Signaling in Anaplastic Thyroid Carcinoma

Kim HJ, Kim MJ, Kim A, Jung CW, Park S, Koh JS, Myung JK

  • Cancer Res Treat.
  • 2017 Apr;49(2):509-517.
  • doi: 10.4143/crt.2016.214
PURPOSE: The Notch signaling pathway is widely expressed in normal, reactive, and neoplastic tissues; however, its role in thyroid tissues has not been fully elucidated. Therefore, this study was conducted...
The Association between End-of-Life Care and the Time Interval between Provision of a Do-Not-Resuscitate Consent and Death in Cancer Patients in Korea

Baek SK, Chang HJ, Byun JM, Han JJ, Heo DS

  • Cancer Res Treat.
  • 2017 Apr;49(2):502-508.
  • doi: 10.4143/crt.2016.073
PURPOSE: We explored the relationship between the use of each medical intervention and the length of time between do-not-resuscitate (DNR) consent and death in Korea. MATERIALS AND METHODS: A total of...
Nationwide Population-Based Incidence and Survival Rates of Malignant Central Nervous System Germ Cell Tumors in Korea, 2005-2012

Lee SH, Jung KW, Ha J, Oh CM, Kim H, Park HJ, Yoo H, Won YJ

  • Cancer Res Treat.
  • 2017 Apr;49(2):494-501.
  • doi: 10.4143/crt.2016.129
PURPOSE: Malignant central nervous system (CNS) germ cell tumors (GCTs), although rare, are thought to occur more frequently among Asians. However, a recent population-based study revealed no differences in GCT...
Young Age Is Associated with Increased Locoregional Recurrence in Node-Positive Breast Cancer with Luminal Subtypes

Kim SW, Chun M, Han S, Jung YS, Choi JH, Kang SY, Yim H, Kang SH

  • Cancer Res Treat.
  • 2017 Apr;49(2):484-493.
  • doi: 10.4143/crt.2016.246
PURPOSE: The effects of biological subtypes within breast cancer on prognosis are influenced by age at diagnosis. We investigated the association of young age with locoregional recurrence (LRR) between patients...
Long-Term Outcome of Distal Cholangiocarcinoma after Pancreaticoduodenectomy Followed by Adjuvant Chemoradiotherapy: A 15-Year Experience in a Single Institution

Kim BH, Kim K, Chie EK, Kwon J, Jang JY, Kim SW, Oh DY, Bang YJ

  • Cancer Res Treat.
  • 2017 Apr;49(2):473-483.
  • doi: 10.4143/crt.2016.166
PURPOSE: This study was conducted to evaluate the long-term outcome in patients undergoing pancreaticoduodenectomy (PD) followed by adjuvant chemoradiotherapy for distal cholangiocarcinoma (DCC) in a high-volume center and to identify...
DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-Induced Skin Fibrosis after Treatment of Breast Cancer: A Multifactorial Genetic Approach

Terrazzino S, Deantonio , Cargnin S, Donis L, Pisani C, Masini L, Gambaro G, Canonico P, Genazzani , Krengli M

  • Cancer Res Treat.
  • 2017 Apr;49(2):464-472.
  • doi: 10.4143/crt.2016.256
PURPOSE: This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We also assessed...
Efficacy of Letrozole as First-Line Treatment of Postmenopausal Women with Hormone Receptor–Positive Metastatic Breast Cancer in Korea

Beom SH, Oh J, Kim TY, Lee KH, Yang Y, Suh KJ, Moon HG, Han SW, Oh DY, Han W, Kim TY, Noh DY, Im SA

  • Cancer Res Treat.
  • 2017 Apr;49(2):454-463.
  • doi: 10.4143/crt.2016.259
PURPOSE: Letrozole showed efficacy and generally favorable toxicities, along with the convenience of oral administration in postmenopausal patients with hormone receptor (HR)–positive metastatic breast cancer (MBC). To the best of...
Outcome and Prognostic Factors for ETV6/RUNX1 Positive Pediatric Acute Lymphoblastic Leukemia Treated at a Single Institution in Korea

Lee JW, Kim SK, Jang PS, Chung NG, Jeong DC, Kim M, Cho B, Kim HK

  • Cancer Res Treat.
  • 2017 Apr;49(2):446-453.
  • doi: 10.4143/crt.2016.211
PURPOSE: ETV6/RUNX1 (+) acute lymphoblastic leukemia (ALL), which is the most common genetic subtype of pediatric ALL, has a favorable prognosis. In this study, we analyzed the outcome of ETV6/RUNX1...
Do Korean Doctors Think a Palliative Consultation Team Would Be Helpful to Their Terminal Cancer Patients?

Shim HY, Chang YJ, Kawk KS, Mai TT, Choi JY, Ahn EM, Jho HJ, Park SJ

  • Cancer Res Treat.
  • 2017 Apr;49(2):437-445.
  • doi: 10.4143/crt.2015.495
PURPOSE: Hospice and palliative care services (HPC) are not commonly utilized in Korea; however, palliative care teams (PCTs) have been found to be effective at addressing the shortcomings in HPC....
The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome

Lener MR, Kashyap A, Kluźniak , Cybulski C, Soluch A, Pietrzak S, Huzarski T, Gronwald J, Lubiński

  • Cancer Res Treat.
  • 2017 Apr;49(2):430-436.
  • doi: 10.4143/crt.2016.217
PURPOSE: Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of...
Feasibility and Efficacy of Eribulin Mesilate in Korean Patients with Metastatic Breast Cancer: Korean Multi-center Phase IV Clinical Study Results

Park YH, Kim TY, Im YH, Lee KS, Park IH, Sohn J, Lee SH, Im SA, Kim JH, Kim SH, Lee SJ, Koh SJ, Lee KH, Choi YJ, Cho EK, Lee S, Kang SY, Seo JH, Kim SB, Jung KH

  • Cancer Res Treat.
  • 2017 Apr;49(2):423-429.
  • doi: 10.4143/crt.2016.191
PURPOSE: Eribulin mesilate was approved for the treatment of patients with locally advanced or metastatic breast cancer (MBC), who had received at least two chemotherapeutic regimens, including anthracycline and taxane....
Phase II Study of Irinotecan and Cisplatin Combination Chemotherapy in Metastatic, Unresectable Esophageal Cancer

Kim M, Keam B, Kim TM, Kim HG, Kim JS, Lee SS, Shin SH, Kim MK, Park KU, Kim DW, Yun HJ, Lee JS, Heo DS

  • Cancer Res Treat.
  • 2017 Apr;49(2):416-422.
  • doi: 10.4143/crt.2016.121
PURPOSE: The objective of this multicenter phase II study was to evaluate the efficacy and safety of irinotecan and cisplatin combination chemotherapy in metastatic, unresectable esophageal cancer. MATERIALS AND METHODS: Patients...
Comparison of Clinical Outcomes of BRCA1/2 Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients

Eoh KJ, Park HS, Park JS, Lee ST, Han J, Lee JY, Kim SW, Kim S, Kim YT, Nam EJ

  • Cancer Res Treat.
  • 2017 Apr;49(2):408-415.
  • doi: 10.4143/crt.2016.135
PURPOSE: The purpose of this study was to investigate the clinical features of epithelial ovarian cancer (EOC) patients according to BRCA1/2 mutation status (mutation, variant of uncertain significance [VUS], or...
Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer

Song IH, Heo SH, Bang WS, Park HS, Park IA, Kim YA, Park SY, Roh J, Gong G, Lee HJ

  • Cancer Res Treat.
  • 2017 Apr;49(2):399-407.
  • doi: 10.4143/crt.2016.215
PURPOSE: The tertiary lymphoid structure (TLS) is an important source of tumor-infiltrating lymphocytes (TILs), which have a strong prognostic and predictive value in triple-negative breast cancer (TNBC). A previous study...
Underexpression of HOXA11 Is Associated with Treatment Resistance and Poor Prognosis in Glioblastoma

Se YB, Kim SH, Kim JY, Kim JE, Dho YS, Kim JW, Kim YH, Woo HG, Kim SH, Kang SH, Kim HJ, Kim TM, Lee ST, Choi SH, Park SH, Kim IH, Kim DG, Park CK

  • Cancer Res Treat.
  • 2017 Apr;49(2):387-398.
  • doi: 10.4143/crt.2016.106
PURPOSE: Homeobox (HOX) genes are essential developmental regulators that should normally be in the silenced state in an adult brain. The aberrant expression of HOX genes has been associated with...

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