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Dexamethasone Inhibits TGF-β1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61

Han S, Bui NT, Ho MT, Kim YM, Cho M, Shin DB

  • Cancer Res Treat.
  • 2016 Jul;48(3):1141-1153.
  • doi: 10.4143/crt.2015.209
PURPOSE: One of the features in cancer development is the migration of cancer cells to form metastatic lesions. CYR61 protein promotes migration and the epithelial-mesenchymal transition in several cancer cell...
Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization

Kim JH, Moon SH, No M, Kim JJ, Choi EJ, Cho BJ, Kim JS, Kim IH, Kim IA

  • Cancer Res Treat.
  • 2016 Jul;48(3):1130-1140.
  • doi: 10.4143/crt.2015.206
PURPOSE: Histone deacetylase (HDAC) inhibitors radiosensitize tumor cells. To elucidate mechanisms underlying radiosensitization by HDAC inhibition, understanding of differential contributions of HDAC isotypes is needed. The aim of this study...
A Multi-centric Bioequivalence Trial in Ph+ Chronic Myeloid Leukemia Patients to Assess Bioequivalence and Safety Evaluation of Generic Imatinib Mesylate 400 mg Tablets

Arora R, Sharma M, Monif T, Iyer S

  • Cancer Res Treat.
  • 2016 Jul;48(3):1120-1129.
  • doi: 10.4143/crt.2015.436
PURPOSE: This study was designed to characterize the pharmacokinetic profile and to assess bioequivalence of the sponsor's test formulation (imatinib mesylate 400 mg tablets) with an innovator product (Gleevec 400...
Clinical Characteristics and Continued Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Administration in EGFR-mutated Non-Small Cell Lung Cancer with Skeletal Metastasis

Hong SH, Kim YS, Lee JE, Kim IH, Kim SJ, Han D, Yoo IR, Chung YG, Kim YH, Lee KY, Kang JH

  • Cancer Res Treat.
  • 2016 Jul;48(3):1110-1119.
  • doi: 10.4143/crt.2015.289
PURPOSE: The aim of this study was to analyze clinical characteristics of skeletal metastasis in epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) and treatment outcomes of...
Variation in Practice Patterns of Korean Radiation Oncologists for Spine Metastasis between 2009 and 2014

Yu JI, Park HC, Ahn YC, Chung Y, Koom WS, Song SY

  • Cancer Res Treat.
  • 2016 Jul;48(3):1102-1109.
  • doi: 10.4143/crt.2015.207
PURPOSE: The Korean Society of Radiation Oncologists (KOSRO) conducted the Patterns of Care Study (PCS) of radiotherapy (RT) for spine metastases in 2009. The current study was conducted to investigate...
Systemic Treatments for Metastatic Renal Cell Carcinoma: 10-Year Experience of Immunotherapy and Targeted Therapy

Kim SH, Park WS, Kim SH, Joung JY, Seo HK, Lee KH, Chung J

  • Cancer Res Treat.
  • 2016 Jul;48(3):1092-1101.
  • doi: 10.4143/crt.2015.316
PURPOSE: The purpose of this study is to compare the outcomes of first-line systemic targeted therapy (TT) and immunotherapy (IT) in patients with metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS:...
Cisplatin, Gemcitabine, and Lapatinib as Neoadjuvant Therapy for Muscle-Invasive Bladder Cancer

Narayan V, Mamtani R, Keefe S, Guzzo T, Malkowicz , Vaughn DJ

  • Cancer Res Treat.
  • 2016 Jul;48(3):1084-1091.
  • doi: 10.4143/crt.2015.405
PURPOSE: We sought to investigate the safety and efficacy of gemcitabine, cisplatin, and lapatinib (GCL) as neoadjuvant therapy in patients with muscle-invasive bladder cancer (MIBC) planned for radical cystectomy. MATERIALS AND...
Adjuvant Treatment after Surgery in Stage IIIA Endometrial Adenocarcinoma

Yoon MS, Huh SJ, Kim HJ, Kim YS, Kim YB, Kim JY, Lee JH, Kim HJ, Cha J, Kim JH, Kim J, Yoon WS, Choi JH, Chun M, Choi Y, Lee KK, Kim M, Jeong JU, Chang SK, Park W

  • Cancer Res Treat.
  • 2016 Jul;48(3):1074-1083.
  • doi: 10.4143/crt.2015.356
PURPOSE: We evaluated the role of adjuvant therapy in stage IIIA endometrioid adenocarcinoma patients who underwent surgery followed by radiotherapy (RT) alone or chemoradiotherapy (CTRT) according to risk group. MATERIALS AND...
The Overexpression of CCAR1 in Hepatocellular Carcinoma Associates with Poor Prognosis

Ha SY, Kim JH, Yang JW, Kim J, Kim B, Park CK

  • Cancer Res Treat.
  • 2016 Jul;48(3):1065-1073.
  • doi: 10.4143/crt.2015.302
PURPOSE: Cell division cycle and apoptosis regulator 1 (CCAR1) plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, β-catenin,...
Serum Concentrations of Selenium and Copper in Patients Diagnosed with Pancreatic Cancer

Lener MR, Scott RJ, Wiechowska-Kozłowska A, Serrano-Fernández P, Baszuk P, Jaworska-Bieniek K, Sukiennicki G, Marciniak , Muszyńska M, Kładny J, Gromowski , Kaczmarek , Jakubowska A, Lubiński

  • Cancer Res Treat.
  • 2016 Jul;48(3):1056-1064.
  • doi: 10.4143/crt.2015.282
PURPOSE: Understanding of the etiology and pathogenesis of pancreatic cancer (PaCa) is still insufficient. This study evaluated the associations between concentrations of selenium (Se) and copper (Cu) in the serum...
Concurrent Chemoradiotherapy Versus Chemotherapy Alone for Unresectable Locally Advanced Pancreatic Cancer: A Retrospective Cohort Study

Choi Y, Oh DY, Kim K, Chie EK, Kim TY, Lee KH, Han SW, Im SA, Kim TY, Ha SW, Bang YJ

  • Cancer Res Treat.
  • 2016 Jul;48(3):1045-1055.
  • doi: 10.4143/crt.2015.226
PURPOSE: The optimal treatment strategy for locally advanced pancreatic cancer (LAPC), particularly the role of concurrent chemoradiotherapy (CCRT), remains debatable. We compared the clinical outcomes of CCRT and palliative chemotherapy...
Relationship between Salt Preference and Gastric Cancer Screening: An Analysis of a Nationwide Survey in Korea

Shin JY, Kim J, Choi KS, Suh M, Park B, Jun JK

  • Cancer Res Treat.
  • 2016 Jul;48(3):1037-1044.
  • doi: 10.4143/crt.2015.333
PURPOSE: Epidemiological studies have demonstrated an association between excessive salt intake and gastric cancer risk, and this potential risk increases the need for adequate gastric cancer screening in individuals with...
Chronological Changes of Quality of Life in Long-Term Survivors after Gastrectomy for Gastric Cancer

Yu W, Park KB, Chung HY, Kwon OK, Lee SS

  • Cancer Res Treat.
  • 2016 Jul;48(3):1030-1036.
  • doi: 10.4143/crt.2015.398
PURPOSE: A few studies have prospectively evaluated changes in quality of life (QoL) after surgery in short-term survivors; however, no prospective study has evaluated the longitudinal changes in QoL in...
Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer

Kim YI, Cho SJ, Lee JY, Kim CG, Kook MC, Ryu KW, Kim YW, Choi IJ

  • Cancer Res Treat.
  • 2016 Jul;48(3):1020-1029.
  • doi: 10.4143/crt.2015.264
PURPOSE: Negative Helicobacter pylori status has been identified as a poor prognostic factor for survival in gastric cancer (GC) patients who underwent surgery. The aim of this study was to...
Cost Effectiveness of Colorectal Cancer Screening Interventions with Their Effects on Health Disparity Being Considered

Lee KS, Park EC

  • Cancer Res Treat.
  • 2016 Jul;48(3):1010-1019.
  • doi: 10.4143/crt.2015.279
PURPOSE: The purpose of this study was to evaluate the cost effectiveness of colorectal cancer screening interventions with their effects on health disparity being considered. MATERIALS AND METHODS: Markov cohort simulation...
What Is the Ideal Tumor Regression Grading System in Rectal Cancer Patients after Preoperative Chemoradiotherapy?

Kim SH, Chang HJ, Kim DY, Park JW, Baek JY, Kim SY, Park SC, Oh JH, Yu A, Nam BH

  • Cancer Res Treat.
  • 2016 Jul;48(3):998-1009.
  • doi: 10.4143/crt.2015.254
PURPOSE: Tumor regression grade (TRG) is predictive of therapeutic response in rectal cancer patients after chemoradiotherapy (CRT) followed by curative resection. However, various TRG systems have been suggested, with subjective...
Splenomegaly and Its Associations with Genetic Polymorphisms and Treatment Outcome in Colorectal Cancer Patients Treated with Adjuvant FOLFOX

Kim MJ, Han SW, Lee DW, Cha Y, Lee KH, Kim TY, Oh DY, Kim SH, Im SA, Bang YJ, Kim TY

  • Cancer Res Treat.
  • 2016 Jul;48(3):990-997.
  • doi: 10.4143/crt.2015.296
PURPOSE: Splenomegaly is a clinical surrogate of oxaliplatin-induced sinusoidal obstruction syndrome (SOS). We investigated development of splenomegaly and its association with treatment outcome and genetic polymorphisms following adjuvant 5-fluorouracil, leucovorin,...
Prospective Study on the Incidence of Postoperative Venous Thromboembolism in Korean Patients with Colorectal Cancer

Lee E, Kang SB, Choi SI, Chun EJ, Kim MJ, Kim DW, Oh HK, Ihn MH, Kim JW, Bang SM, Lee JO, Kim YJ, Kim JH, Lee JS, Lee KW

  • Cancer Res Treat.
  • 2016 Jul;48(3):978-989.
  • doi: 10.4143/crt.2015.311
PURPOSE: Pharmacologic thromboprophylaxis is routinely recommended for Western cancer patients undergoing major surgery for prevention of venous thromboembolism (VTE). However, it is uncertainwhetherroutine administration of pharmacologic thromboprophylaxis is necessary in...
In Vitro Adenosine Triphosphate-Based Chemotherapy Response Assay as a Predictor of Clinical Response to Fluorouracil-Based Adjuvant Chemotherapy in Stage II Colorectal Cancer

Kwon HY, Kim IK, Kang J, Sohn SK, Lee KY

  • Cancer Res Treat.
  • 2016 Jul;48(3):970-977.
  • doi: 10.4143/crt.2015.140
PURPOSE: We evaluated the usefulness of the in vitro adenosine triphosphate-based chemotherapy response assay (ATP-CRA) for prediction of clinical response to fluorouracil-based adjuvant chemotherapy in stage II colorectal cancer. MATERIALS AND...
Delay of Treatment Initiation Does Not Adversely Affect Survival Outcome in Breast Cancer

Yoo TK, Han W, Moon HG, Kim J, Lee JW, Kim MK, Lee E, Kim J, Noh DY

  • Cancer Res Treat.
  • 2016 Jul;48(3):962-969.
  • doi: 10.4143/crt.2015.173
PURPOSE: Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was to analyze the overall...

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