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Arsenic Trioxide Induces Apoptosis of HL-60 Cells via Activation of Intrinsic Caspase Protease with Mitochondrial Dysfunction

Jung BH, Park C, Kim HR, Park MR

  • Cancer Res Treat.
  • 2002 Aug;34(4):308-315.
Arsenic trioxide (As2O3) was introduced into the treatment of refractory or relapsed acute promyelocytic leukemia and showed a striking effectiveness in China and United States multicenter study. However, the mechanistic...
Suppression of Peritoneal Metastases by Expression of Murine Endostatin cDNA

Choi SH, Lee JH, Hong SH, Hyung WJ, Noh SH, Chung HC, Roh JK, Min JS

  • Cancer Res Treat.
  • 2002 Aug;34(4):302-307.
Peritoneal seeding is one of problems to be solved in gastrointestinal and ovarian cancers. Angiogenesis is the critical step for a dormancy tumor cluster to be an overt metastatic nodule....
5-Fluorouracil and Cisplatin (FP) with Concurrent Radiotherapy for Locally Advanced Head and Neck Cancer

Kim HS, Kim KS, Bea SS, Oh SJ, Lee KH, Kim WD, Park WY, Kim ST

  • Cancer Res Treat.
  • 2002 Aug;34(4):296-301.
The combination of chemotherapy and radiotherapy is emerging as the new standard modality for the treatment of locally advanced head and neck cancer, due to the inherent functional and cosmetic...
The Outcome of Philadelphia Chromosome-Positive Adult ALL: Characteristics and Prognosis

Song HH, Lee JH, Jeon BM, Lee JH, Seo EJ, Park CJ, Chi HS, Lee JS, Kim WK, Lee KH

  • Cancer Res Treat.
  • 2002 Aug;34(4):289-295.
The Philadelphia (Ph) chromosome is a well- known chromosome abnormality in adults with B-lineage ALL, and is associated with a poor prognosis. This study compared the clinical manifestations and prognosis...
Treatment Outcome of Brain Metastasis after the Cranial Radiotherapy Followed by Fractionated Stereotactic Radiotherapy and Its Prognostic Factors

Kim HJ, Hong S, Kim S, Kim JH, Kim IH, Park CI, Ha SW, Wu HG, Kang WS

  • Cancer Res Treat.
  • 2002 Aug;34(4):284-288.
To evaluate the effectiveness of whole brain radiotherapy followed by stereotactic radiotherapy for newly diagnosed brain metastasis. MATERIALS AND METHODS: Thirty-three metastatic brain tumors received radiotherapy to the whole brain and...
Pirarubicin, UFT, Leucovorin Chemotherapy in Non-embolizable and Transcatheter Arterial Chemoembolization-Failed Hepatocellular Carcinoma Patients; A Phase II Clinical Study

Park KH, Yoon SY, Oh SC, Seo JH, Choi CW, Yeon JE, Kim BS, Shin SW, Kim YH, Byun KS, Kim JS, Lee CH

  • Cancer Res Treat.
  • 2002 Aug;34(4):280-283.
Hepatocellular carcinomas are one of the most common malignancies in the world. However, no effective therapeutic modality has been proven to prolong the survival of patients in an inoperable stage....
A Phase II Study of Gemcitabine Monotherapy in Breast Cancer Patients Refractory to Anthracycline and Taxane

Park JY, Kim C, Sohn JH, Kim YT, Rha SY, Jang WI, Kim GE, Chung HC

  • Cancer Res Treat.
  • 2002 Aug;34(4):274-279.
We performed a phase II trial to evaluate the efficacy and the safety of gemcitabine monotherapy, a pyrimidine antimetabolite, in patients, who had previously failed anthracycline and taxane-based chemotherapy for...
Expression of G1/S Phase Checkpoint Proteins in Breast Carcinoma: Relationship to Clinicopathologic Factors andSurvival Rate

Lee MJ

  • Cancer Res Treat.
  • 2002 Aug;34(4):268-273.
The retinoblastoma protein (pRb)/cyclin D1/ p16 pathway plays a critical role in controlling the progression from G1 to S phase of the cell cycle. Abnormal expression of the individual components...
The Effects of Irradiation on Lung Function in Patients with Lung Cancer

Gang KH, Park JY, Kim KR, Chae PH, Bae NC, Cha SI, Kim CH, Jung TH

  • Cancer Res Treat.
  • 2002 Aug;34(4):264-267.
This study was performed to assist in the prediction of the clinical tolerance of patients with lung cancer to irradiation. MATERIALS AND METHODS: The changes in lung function of 26...
Altered Retinoblastoma Protein Expression and Proliferative Activity in Urethane Induced Mouse Lung Tumorigenesis

Chung JH, Jang JJ, Lee MJ, Ham EK

  • Cancer Res Treat.
  • 2002 Aug;34(4):258-263.
Lung cancer develops through a multistage process involving the accumulation of diverse genetic alterations. To gain an understanding of the roles played by tumor suppressor gene proteins and proliferating cell...
Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis

Chae SW, Sohn JH, Shin HS, Park YE

  • Cancer Res Treat.
  • 2002 Aug;34(4):252-257.
PURPOSE: The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of human cancers. We investigated COX-2 expression in normal, gastric adenomas and adenocarcinomas. MATERIALS AND METHODS:...
Analysis of Local Recurrence Following Proximal Gastrectomy in Patients with Upper Third Gastric Cancer

Yoo CH, Sohn BH, Han WK, Pae WK

  • Cancer Res Treat.
  • 2002 Aug;34(4):247-251.
PURPOSE: Little is known about local recurrence following proximal gastrectomy in patients with upper third gastric cancer. We performed this study to evaluate the long-term results of a proximal gastrectomy,...

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