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Practical issues in CAR T-cell therapy

Byun JM

Chimeric antigen receptor (CAR) T-cell therapy presents a revolutionary advancement in personalized cancer treatment. During the production process, the patient's own T-cells are genetically engineered to express a synthetic receptor...
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Reduced-intensity conditioning versus myeloablative conditioning allogeneic stem cell transplantation for patients with myelofibrosis

Kim DH, Seo J, Shin DY, Koh Y, Hong J, Kim I, Yoon SS, Byun JM

Background Allogeneic hematopoietic stem cell transplantation (alloSCT) is the sole curative option for myelofibrosis (MF). However, it is unknown as to which of the two, myeloablative conditioning (MAC) or reduced-intensity conditioning...
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Chimeric Antigen Receptor-T Cell Therapy

Byun JM, Yoon SS

Chimeric antigen receptor (CAR) T-cell therapy constitutes a revolutionary advancement in personalized cancer treatment. During this treatment, a patient's own T cells are genetically engineered to express a synthetic receptor...
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IDH1/2 mutations in acute myeloid leukemia

Byun JM, Yoo SJ, Kim HJ, Ahn JS, Koh Y, Jang JH, Yoon SS

The mutational and epigenetic landscape of acute myeloid leukemia (AML) has become increasingly well understood in recent years, informing on biological targets for precision medicine. Among the most notable findings...
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How myeloproliferative neoplasms patients’ experience and expectations differ from physicians’: the international MPN Landmark survey

Byun JM, Bang SM, Choi EJ, Eom KS, Jung CW, Kim Hs, Park J, Choi CW

Background/Aims: Recent advances in the understanding of the pathophysiology of myeloproliferative neoplasms (MPN) were not paralleled with advances in treatment options; thus many questions regarding optimal MPN management remain unanswered....
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Eltrombopag for Post-Transplant Poor Graft Function in East Asian Patients

Ahn HJ, Byun JM, Kim I, Youk J, Koh Y, Shin DY, Hong J, Yoon SS

Poor graft function (PGF) is a serious, potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation. Eltrombopag has shown multilineage responses in patients with refractory severe aplastic anemia, supporting the...
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Maternal and Fetal Risk Factors Associated with Neonatal Intensive Care Unit Admis sion in Term Neonates

Ku TI, Kim YN, Im DH, Kim YS, Kim DH, Byun JM, Jeong DH

Objective: This study aimed to evaluate the risk factors associated with neonatal intensive care unit (NICU) admission in term neonates and to provide necessary data for antenatal counseling. Methods: This retrospective...
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Multicenter retrospective analysis of patients with chronic lymphocytic leukemia in Korea

Yi JH, Lee GW, Lee JH, Yoo KH, Jung CW, Kim DS, Lee JO, Eom HS, Byun JM, Koh Y, Yoon SS, Kim JS, Kong JH, Yhim HY, Yang DH, Yoon DH, Lim DH, Lee WS, Shin HJ

Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western countries but is rare in the East Asian countries. Due to its rarity and the lack...
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Romiplostim plus danazol as salvage treatment for eltrombopag refractory immune thrombocytopenia: a retrospective pilot study

Nam CH, Byun JM, Shin DY, Hong J, Kim I, Yoon SS, Koh Y

No abstract available
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Leukemic stem cell phenotype is associated with mutational profile in acute myeloid leukemia

Han H, Byun JM, Shin DY, Yoon SS, Koh Y, Hong J, Kim I, Lee C, Yoo H, Yun H, Kim MJ, Cho SI, Seong MW, Park SS

Background/Aims: Understanding leukemic stem cell (LSC) is important for acute myeloid leukemia (AML) treatment. However, association of LSC with patient prognosis and genetic information in AML patients is unclear. Methods: Here...
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Pilot study for the Psychometric Validation of the Sheffield Profile for Assessment and Referral to Care (SPARC) in Korean Cancer Patients

Kwon JH, Baek SK, Kim DY, Kim YJ, Lee MA, Choi HJ, Byun JM, Jeong JY, Ahmedzai SH, Jang GD

Purpose This study aimed to validate the Sheffield Profile for Assessment and Referral to Care (SPARC) as an effective tool for screening palliative care needs among Korean cancer patients. Materials and Methods The...
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High Cell-Free DNA Levels in Cerebrospinal Fluid Predict Leptomeningeal Seeding of Hematologic Malignancy

Kim EY, Lee ST, Kim YS, Byun JM, Hong J, Shin DY, Koh Y, Kim I

Background and Purpose: The main difficulty when diagnosing leptomeningeal metastases (LMSs) is the low sensitivity of cytology. Cancer cells release cell-free DNA (cfDNA) during proliferation and apoptosis, and so we...
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Epidemiology of Congenital Bleeding Disorders: a Nationwide Populationbased Korean Study

Yoon HS, Han Y, Kim YJ, Kim MJ, Byun JM, Youk T, Lee JH, Park TS, Yoo J

Background: Except for data in the Korea Hemophilia Foundation Registry, little is known of the epidemiology of congenital bleeding disorders in Korea. Methods: Data were obtained from the Korean Health Insurance...
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Gradual Increase in Hematologic Malignancy in Korea from 2005 to 2015 Based on the National Health Insurance Service Data

Han Y, Kim YJ, Kim MJ, Byun JM, Youk T, Yoon HS, Lee JH, Lee WI, Park TS, Yoo J

Background Hematologic malignancies have a relatively lower prevalence than major solid cancers, although the incidence of hematologic malignancies has significantly increased in recent years. However, understanding the current status of hematologic...
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Ovarian dysgerminoma with Müllerian anomaly: a case report

Kim HN, Byun JM, Park JO, Yoon HK, Kim DH, Jeong DH, Kim YN, Lee KB, Sung MS

Müllerian anomalies are rare deformities in women, and only a few cases concerning gynecologic malignancies arising in patients with congenital uterine malformations have been reported. Herein, we present the case...
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Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in management of peritoneal carcinomatosis: Single center experience in Korea

Lee HJ, Baik H, Park YH, Seo SH, Kim KH, Bae KB, Hong KH, Kim KH, Byun JM, Jeong DH, Lee KB, Oh MK, Cho KR, An MS

PURPOSE: Peritoneal carcinomatosis (PC) has been considered a terminal condition and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIEPC) is regarded as an alternative therapeutic option. This study aimed to evaluate...
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Posterior Reversible Encephalopathy Syndrome in Late Postpartum Eclampsia: A Case Report

Kwon MJ, Kim DH, Byun JM, Kim YN, Lee KB, Sung MS, Jeong DH

Late postpartum eclampsia is defined as the onset of a seizure more than 48 hours after delivery. Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiological entity characterized by clinical manifestations...
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Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance

Suh KJ, Kim KH, Kim R, Byun JM, Kim M, Park JH, Keam B, Kim TM, Kim JS, Choi IS, Heo DS

BACKGROUND/AIMS: The role of [18F]-f luorodeoxyglucose positron emission tomography-computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear. METHODS: Medical costs within the first 3...
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Clinical and Genetic Characteristics of BRCA1/2 Mutation in Korean Ovarian Cancer Patients: A Multicenter Study and Literature Review

Kwon BS, Byun JM, Lee HJ, Jeong DH, Lee TH, Shin KH, Suh DS, Kim KH

PURPOSE: We investigated the clinical relevance and spectrum of BRCA1/2 mutations in Korean ovarian cancer (KoOC) patients. MATERIALS AND METHODS: Two hundred seventy-nine KoOC patients were enrolled from three university hospitals...
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The first case of vaginal angiomatoid Spitz nevus causing vaginal bleeding

Park YH, Byun JM, Cho HJ, Jeong DH, Kim YN, Park HR, Lee KB, Sung MS

Angiomatoid Spitz nevus is a variant of melanocytic nevus with prominent vasculature. Due to its pathologic features, angiomatoid Spitz nevus in the vaginal wall is extremely rare. A 42-year-old woman...
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