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Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant

Park YM, Lee SY, Kang MJ, Kim BS, Lee MJ, Jung SS, Yoon JS, Cho HJ, Lee E, Yang SI, Seo JH, Kim HB, Suh DI, Shin YH, Kim KW, Ahn K, Hong SJ

PURPOSE: The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and...
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Short-chain Fatty Acids Inhibit Staphylococcal Lipoprotein-induced Nitric Oxide Production in Murine Macrophages

Park JW, Kim HY, Kim MG, Jeong S, Yun CH, Han SH

Staphylococcus aureus, a Gram-positive pathogen, can cause severe inflammation in humans, leading to various life-threatening diseases. The lipoprotein is a major virulence factor in S. aureus-induced infectious diseases and is...
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The Effect of Microbiota on Colon Carcinogenesis

Yoon K, Kim N

Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ’s extensive interaction with microbes necessitated research on the role of...
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The Suppressive Effect of Butyrate and Bromopyruvate on Inflammatory Cytokine Production and Short Chain Fatty Acid Receptor Expression by Blood Mononuclear Cells in Patients with Behçet's Disease

Yun SJ, Kim K, Lee ES, Park S

BACKGROUND: Controlling inflammation is a therapeutic goal of various autoimmune/autoinflammatory diseases including Behçet's disease (BD). The immunomodulatory effect of metabolites or metabolic analogs such as butyrate and 3-bromopyruvate has been...
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Oral Proton Pump Inhibitor for Treatment of Congenital Chloride Diarrhea

Jo HC, Yoon JS, Jang JY, Sohn YB, Lee JH, Cheong HI, Park MS

Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease, which is characterized by electrolyte absorption defect due to impaired function of the Cl-/HCO3 - exchanger in the ileum and the...
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Betamethasone Butyrate Propionate Inhibits the Induction of Thymic Stromal Lymphopoietin in Cultured Normal Human Keratinocytes

Zhang W, Sakai T, Hatano Y, Fujiwara S

No abstract available.
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Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway

Jung TH, Park JH, Jeon WM, Han KS

BACKGROUND/OBJECTIVES: Fermentation of dietary fiber results in production of various short chain fatty acids in the colon. In particular, butyrate is reported to regulate the physical and functional integrity of...
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Analysis of porcine macrophage immune response to antigenic molecules and short chain fatty acids

Han NE, Lee EJ, Park KS, Jeon IS, Lee HK, Song KD, Choi JK

Macrophages play an important role in both the innate and adaptive immune responses. These include phagocytosis, killing of microorganisms, antigen presentation, and induction of immune cytokines and antimicrobial genes. Macrophage...
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Analysis of the Expression Pattern of microRNA of KSHV in KSHV-infected Human Cells

Kim S, Jang J, Lee MS, Yoo SM

Kaposi's sarcoma associated herpesvirus (KSHV) is subdivided into gamma-herpesvirus and causes Kaposi's sarcoma in human immunodeficiency virus (HIV)-infected patients. A defining feature of herpesviral biology is the presence of two...
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Enhancement of Protein Productivity of Recombinant Hepatitis A Virus VP1 in Stably Transfected Drosophila melanogaster S2 Cells

Jeon HB, Park JH, Lee HH, Kim DH, Lee HY, Shon DH, Kim W, Chung IS

The effect of DMSO and sodium butyrate on the production of recombinant hepatitis A virus (HAV) capsid protein VP1 was evaluated and optimized in the culture of stably transfected Drosophila...
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KLF4 Expression Correlates with the Degree of Differentiation in Colorectal Cancer

Hu R, Zuo Y, Zuo L, Liu C, Zhang S, Wu Q, Zhou Q, Gui S, Wei W, Wang Y

  • KMID: 2135086
  • Gut Liver.
  • 2011 Jun;5(2):154-159.
BACKGROUND/AIMS: Kruppel-like factor 4 (KLF4) is an epithelial-specific transcription factor primarily expressed in the gastrointestinal tract that mediates growth arrest in the colonic epithelium. We tried to find whether KLF4...
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Nitric Oxide Is an Essential Mediator for Neuronal Differentiation of Rat Primary Cortical Neuron Cells

Oh SJ, Heo JI, Kho YJ, Kim JH, Kang HJ, Park SH, Kim HS, Shin JY, Kim MJ, Kim SC, Park JB, Kim J, Lee JY

Nitric oxide (NO) regulates proliferation, differentiation and survival of neurons. Although NO is reported to involve in NGF-induced differentiation of PC12 cells, the role of NO has not been characterized...
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Narcolepsy: Clinical Feature, Diagnosis and Treatment

Shin HB

  • KMID: 2317492
  • Sleep Med Psychophysiol.
  • 2010 Dec;17(2):63-68.
Narcolepsy is a central neurologic system disease. It begins early in life with disabling symptoms including excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucination and nocturnal sleep fragmentation. Patient with...
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Effects of a soluble dietary fibre NUTRIOSE(R) on colonic fermentation and excretion rates in rats

Guerin-Deremaux L, Ringard F, Desailly F, Wils D

  • KMID: 2313482
  • Nutr Res Pract.
  • 2010 Dec;4(6):470-476.
The resistant dextrin NUTRIOSE(R), developed from starch, is expected to act as a prebiotic. The aim of this study was to determine the effects of NUTRIOSE(R) on cecal parameters, short-chain...
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Induction of growth inhibition and apoptosis in human endometrial cancer cells by histone deacetylase inhibitors

Lim SY, Choi JK, Shin SJ, Kwon SH, Cho CH, Cha SD, Song DK

  • KMID: 2273759
  • Korean J Obstet Gynecol.
  • 2009 Sep;52(9):911-919.
OBJECTIVE: Endometrial cancer is the most common malignant tumor of the female genital tract. Its incidence has increased in recent years, making up 13% of female genital cancers. Nevertheless, the...
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The Combination Effect of Sodium Butyrate, 5-aza-2'-deoxycytidine on the Tumor Suppressive Activity in RKO Colorectal Cancer and MCF-7 Breast Cancer Cell Lines

Cho HJ, Park SC, Kim KW, Kang WK, Cho HM, Kim JS, Kim YA, An CH

PURPOSE: It is known that DNA methylation is associated with histone acetylation status in regulation of gene expression. In this study, we investigate the effect of demethylating agents and histone...
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The Changes of Expression of Survivin by Butyrate in HCT116 Colon Cancer Cells

Park DG

PURPOSE: The causes of colon cancer can be divided into genetic and environmental components. A high-fiber diet is known to reduce the risk of colon cancer. Dietary fiber is converted...
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Effect of Decursin on the Expression of beta-Catenin and Matrix Metalloproteinase-7 in Prostate Cancer Cell Lines

Choi IJ, Min K, Oh S, Song GY, Kang D

PURPOSE: Alterations in the Wnt/beta-catenin pathway are associated with the development and progression of human prostate cancer. Decursin can attenuate the Wnt/beta-catenin pathway. We investigated the relationship between the Wnt/beta-catenin...
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Protective Effect of Decursinol on Mouse Models of Sepsis: Enhancement of Interleukin-10

Jung JS, Yan JJ, Song DK

The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models...
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Effects of High Amylose Starch on Gut Functions in Rats

Seol SM, Bang MH, Jeong MK, Kim WK

  • KMID: 2269634
  • Korean J Nutr.
  • 2003 Mar;36(2):109-116.
This study investigated the effects of high amylose starch (HAS) consumption on gut functions in male Sprague-Dawley rats. Experimental animals were fed an diet containing HAS for 4 weeks (0,...
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