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Serial Short-Term Outcomes of VeryLow-Birth-Weight Infants in the Korean Neonatal Network From 2013 to 2020

Jeon GW, Lee JH, Oh M, Chang YS

Background: We aimed to determine the current survival rate and short-term outcomes of very-low-birth-weight infants (VLBWIs) in Korea, as well as whether the survival rate and short-term outcomes have improved...
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Association of Maternal Hypertensive Disorders During Pregnancy With Severe Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis

Lim G, Kim YJ, Chung S, Park YM, Kim KS, Park HW

Background: This meta-analysis was performed to examine the association between maternal hypertension during pregnancy (HDP) and neonatal bronchopulmonary dysplasia (BPD). Methods: We systematically searched PubMed, EMBASE, the Cochrane Library, and the...
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Right Atrial Strain in Preterm Infants With a History of Bronchopulmonary Dysplasia

Kang SJ, Jung H, Hwang SJ, Kim HJ

BACKGROUND: Few studies have utilized right atrial (RA) strain to evaluate right ventricular (RV) diastolic dysfunction in preterm infants with bronchopulmonary dysplasia (BPD). We aimed to evaluate the associations of...
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Eosinophil activation markers in blood and urine in preterms developing bronchopulmonary dysplasia

Choi SH, Chung SH, Lee KS, Bae CW, Rha YH

Purpose: Eosinophil-derived neurotoxin (EDN) is not the only a marker for eosinophil activation, but also acts as an alarm protein. Very few studies have examined the potential role of eosinophils in...
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Lung Volume Reduction Surgery in Preterm Infant with Giant Bullae due to Bronchopul monary Dysplasia: A Case Report

Bae MH, Lee YJ, Lee N, Jeong MH, Jeong SH, Han YM, Byun SY, Ahn HY, Park KH

Bronchopulmonary dysplasia (BPD) is still a common problem in premature infants. Some BPD patients develop acquired lobar emphysema (ALE). There is no satisfactory way to improve ALE in preterm infants...
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Comparison of Respiratory Outcome between the Surfactant without Endotracheal Tube Intubation and the Intubation-SurfactantExtubation Techniques in Extremely Low Gestational Age Neonates with Respi­ratory Distress Syndrome

Cha T, Jeong J, Lee BS, Kim EAR, Kim KS, Jung E

Objective: The aim of this study was to determine whether there were differences in respiratory out comes of extremely low gestational age neonates according to the surfactant without endotracheal tube...
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The Prediction of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants through Clinical Indicators within 1 Hour of Delivery

Shim SY, Yun JY, Cho SJ, Kim MH, Park EA

Background: Despite the advances in neonatology, the incidence of bronchopulmonary dysplasia (BPD) is increasing. It is important to prevent the development of BPD in the first place. The online BPD...
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The protective effect of CXC chemokine receptor 2 antagonist on experimental bronchopulmonary dysplasia induced by postnatal systemic inflammation

Lee SH, Choi CW

Background: Animal studies have shown that a leukocyte influx precedes the development of bronchopulmonary dysplasia (BPD) in premature sheep. The CXC chemokine receptor 2 (CXCR2) pathway has been implicated in...
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Risk Factors and Neonatal Outcomes of Patent Ductus Arteriosus Ligation in Preterm Infants in a Single Center over 6 Years

Jeon GW

Objective: To determine the effects of patent ductus arteriosus (PDA) ligation, clinical characteristics of infants who need surgical ligation of PDA and risk factors of PDA ligation were evaluated. Methods: Preterm...
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Morbidity and Mortality of Very Low Birth Weight Infants with Congenital Heart Disease

Song WS, Kim CY, Lee BS, Kim EAR, Kim KS, Jung E

Background and Objectives: This study aimed to provide morbidity and mortality information on very low birth weight (VLBW) infants with congenital heart disease (CHD-VLBWs). Methods: The study used a 10-year cohort...
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Differences in Outcomes According to the Time of Patent Ductus Arteriosus Closure in Preterm Infants

Han C, Jeon GW

Purpose: Patent ductus arteriosus (PDA) is associated with increased mortality and morbidities such as intraventricular hemorrhage, necrotizing enterocolitis, bronch opulmonary dysplasia, and neurodevelopmental impairment. The objective of this study was...
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Cell Division Cycle 2 Protects Neonatal Rats Against Hyperoxia-Induced Bronchopulmonary Dysplasia

Li Z, Chen Y, Li W, Yan F

Purpose: Hyperoxia-induced bronchopulmonary dysplasia (BPD) is a lung disease in preterm infants. We aimed to explore the role of cell division cycle 2 (CDC2) on histopathologic changes of lung tissues,...
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Comparison Between Sodium Acetate and Sodium Chloride in Parenteral Nutrition for Very Preterm Infants on the Acid-Base Status and Neonatal Outcomes

Ali A, Ong EY, Singh BKS, Cheah FC

Purpose: To compare between sodium acetate (SA) and sodium chloride (SC) in parenteral nutrition (PN) with associated metabolic acidosis and neonatal morbidities in preterm infants. Methods: Preterm infants below 33 weeks...
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Intratracheal Transplantation of Amnion-Derived Mesenchymal Stem Cells Ameliorates Hyperoxia-Induced Neonatal Hyperoxic Lung Injury via Aminoacyl-Peptide Hydrolase

Li Z, Gong X, Li D, Yang X, Shi Q, Ju X

Background and Objectives: Bronchopulmonary dysplasia (BPD) has major effects in premature infants. Although previous literature has indicated that mesenchymal stem cells (MSCs) can alleviate lung pathology in BPD newborns and...
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Factors Associated with Clinical Response to Low-Dose Dexamethasone Therapy for Bronchopulmonary Dysplasia in Very Low Birth Weight Infants

Shin J, Kim SH, Jung YH, Choi CW, Kim BI

Purpose: To identify factors associated with the clinical response to low-dose dexamethasone therapy (LDDT) in preterm infants for bronchopulmonary dysplasia (BPD). Methods: We used a retrospective medical record review to evaluate...
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Changes in the Incidence of Bronchopulmonary Dysplasia among Preterm Infants in a Single Center over 10 Years

Jeon GW

Purpose: Bronchopulmonary dysplasia (BPD) is one of the most fatal respiratory morbidities in preterm infants, causing adverse respiratory and neurodevelopmental outcomes. Despite advances in neonatal ventilator care, the incidence of...
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Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants

Lee EY, Kim SS, Park GY, Lee SH

Background: Red blood cell (RBC) transfusion improves cardiorespiratory status of preterm infants by increasing circulating hemoglobin, improving tissue oxygenation, and reducing cardiac output. However, RBC transfusion itself has also been...
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Bronchopulmonary dysplasia: how can we improve its outcomes?

Sung TJ

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years,...
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Effects of Early Phosphorus Intake on Respiratory Distress in Extremely Low-Birth-Weight Infants

Bae HJ, Yoon HW, Kim MJ, Jung AH, Jung SH, Hahn HJ, Jo YH, Cho YS, Kim EK, Shin SH, Song IG, Shin SH

PURPOSE: This study was aimed to investigate the effect of early phosphorus intake on respiratory distress in extremely low-birth-weight infants (ELBWIs) with a high incidence of hypophosphatemia. METHODS: We performed a...
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Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants

Kim I, Kim SS, Song JI, Yoon SH, Park GY, Lee YW

PURPOSE: This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs:
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