- Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila
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Ghimire S, Kim MS
- KMID: 2380340
- Biomol Ther.
- 2015 May;23(3):290-295.
- doi: 10.4062/biomolther.2014.147
Aging is defined as a collective process that alters organism's functional capacity and appearance over the course of life. Apart from an increase in susceptibility to many diseases, aging affects... -
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- Role of Micronutrients in Skin Health and Function
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Park K
- KMID: 2380329
- Biomol Ther.
- 2015 May;23(3):207-217.
- doi: 10.4062/biomolther.2015.003
Skin is the first line of defense for protecting our bodies against external perturbations, including ultraviolet (UV) irradiation, mechanical/chemical stress, and bacterial infection. Nutrition is one of many factors required... -
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- Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling
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Han YS, Lee JH, Lee SH
- KMID: 2380331
- Biomol Ther.
- 2015 May;23(3):225-232.
- doi: 10.4062/biomolther.2014.136
We identified a novel Akt signaling mechanism that mediates fucoidan-induced suppression of human colon cancer cell (HT29) proliferation and anticancer effects. Fucoidan treatment significantly inhibited growth, induced G1-phase-associated upregulation of... -
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- Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus
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Lee CH, Yi MH, Chae DJ, Zhang E, Oh SH, Kim DW
- KMID: 2380336
- Biomol Ther.
- 2015 May;23(3):261-267.
- doi: 10.4062/biomolther.2014.146
Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor gamma agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the... -
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- The Inhibitory Effect of Shikonin on the Agonist-Induced Regulation of Vascular Contractility
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Je HD, Kim HD, La HO
- KMID: 2380332
- Biomol Ther.
- 2015 May;23(3):233-237.
- doi: 10.4062/biomolther.2014.148
Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin... -
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- Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities
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Roh HJ, Noh HJ, Na CS, Kim CS, Kim KH, Hong CY, Lee KR
- KMID: 2380339
- Biomol Ther.
- 2015 May;23(3):283-289.
- doi: 10.4062/biomolther.2014.140
The half-dried leaves of Stewartia. pseudocamellia were extracted with hot water (SPE) and partitioned with n-hexane (SPEH), dichloromethane (SPED), and ethyl acetate (SPEE) successively. SPE and SPEE showed significant inhibitory... -
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- Preclinical Pharmacokinetic Evaluation of beta-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats
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Kim I, Kim H, Ro J, Jo K, Karki S, Khadka P, Yun G, Lee J
- KMID: 2380341
- Biomol Ther.
- 2015 May;23(3):296-300.
- doi: 10.4062/biomolther.2015.029
beta-Lapachone has drawn increasing attention as an anti-inflammatory and anti-cancer drug. However, its oral bioavailability has not been yet assessed, which might be useful to develop efficient dosage forms possibly... -
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- Protective Effects of Silibinin and Its Possible Mechanism of Action in Mice Exposed to Chronic Unpredictable Mild Stress
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Yan WJ, Tan YC, Xu JC, Tang XP, Zhang C, Zhang PB, Ren ZQ
- KMID: 2380334
- Biomol Ther.
- 2015 May;23(3):245-250.
- doi: 10.4062/biomolther.2014.138
Silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, has recently been identified as having anti-hepatotoxic and anticancer properties. In this paper, we investigated the effects... -
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- Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice
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Mabunga DF, Gonzales E, Kim HJ, Choung SY
- KMID: 2380337
- Biomol Ther.
- 2015 May;23(3):268-274.
- doi: 10.4062/biomolther.2015.022
gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian central nervous system, is involved in sleep physiology. Caffeine is widely used psychoactive substance known to induce wakefulness and insomnia... -
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- Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-gamma Stimulated HaCaT Human Keratinocytes
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Kang NJ, Koo DH, Kang GJ, Han SC, Lee BW, Koh YS, Hyun JW, Lee NH, Ko MH, Kang HK, Yoo ES
- KMID: 2380333
- Biomol Ther.
- 2015 May;23(3):238-244.
- doi: 10.4062/biomolther.2014.141
Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22... -
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- Neuroprotective and Antioxidant Effects of Novel Benzofuran-2-Carboxamide Derivatives
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Cho J, Park C, Lee Y, Kim S, Bose S, Choi M, Kumar AS, Jung JK, Lee H
- KMID: 2380338
- Biomol Ther.
- 2015 May;23(3):275-282.
- doi: 10.4062/biomolther.2015.030
In the present study, we synthesized a series of novel 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives in moderate to good yields and evaluated their neuroprotective and antioxidant activities using primary cultured rat cortical... -
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- A Cannabinoid Receptor Agonist N-Arachidonoyl Dopamine Inhibits Adipocyte Differentiation in Human Mesenchymal Stem Cells
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Ahn S, Yi S, Seo WJ, Lee MJ, Song YK, Baek SY, Yu J, Hong SH, Lee J, Shin DW, Jeong LS, Noh M
- KMID: 2380330
- Biomol Ther.
- 2015 May;23(3):218-224.
- doi: 10.4062/biomolther.2014.137
Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and peroxisome proliferator-activated receptor gamma (PPARgamma). The stimuli to... -
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- Repeated Neonatal Propofol Administration Induces Sex-Dependent Long-Term Impairments on Spatial and Recognition Memory in Rats
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Gonzales E, Yang SM, Choi CS, Mabunga DF, Kim HJ, Cheong JH, Ryu JH, Koo BN, Shin CY
- KMID: 2380335
- Biomol Ther.
- 2015 May;23(3):251-260.
- doi: 10.4062/biomolther.2014.120
Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment... -
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