- Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents
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Cha HJ, Lee HA, Ahn JI, Jeon SH, Kim EJ, Jeong HS
- KMID: 2170677
- Biomol Ther.
- 2013 Jul;21(4):307-312.
Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However,... -
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- Sphingolipids and Antimicrobial Peptides: Function and Roles in Atopic Dermatitis
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Park K, Lee S, Lee YM
- KMID: 2170669
- Biomol Ther.
- 2013 Jul;21(4):251-257.
Inflammatory skin diseases such as atopic dermatitis (AD) and rosacea were complicated by barrier abrogation and deficiency in innate immunity. The first defender of epidermal innate immune response is the... -
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- Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Induced by Urotensin II in Human Vascular Endothelial Cells
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Park SL, Lee BK, Kim YA, Lee BH, Jung YS
- KMID: 2170673
- Biomol Ther.
- 2013 Jul;21(4):277-283.
In this study, we investigated the effects of a selective urotensin II (UII) receptor antagonist, SB-657510, on the inflammatory response induced by UII in human umbilical vein endothelial cells (EA.hy926)... -
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- Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells
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Youn CK, Park SJ, Lee MY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ
- KMID: 2170670
- Biomol Ther.
- 2013 Jul;21(4):258-263.
We demonstrate herein that silibinin, a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), inhibits LPS-induced activation of macrophages and production of nitric oxide (NO) in RAW 264.7 cells.... -
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- Fucoxanthin Protects Cultured Human Keratinocytes against Oxidative Stress by Blocking Free Radicals and Inhibiting Apoptosis
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Zheng J, Piao MJ, Keum YS, Kim HS, Hyun JW
- KMID: 2170672
- Biomol Ther.
- 2013 Jul;21(4):270-276.
Fucoxanthin is an important carotenoid derived from edible brown seaweeds and is used in indigenous herbal medicines. The aim of the present study was to examine the cytoprotective effects of... -
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- Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
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Hong SH, Heo JI, Kim JH, Kwon SO, Yeo KM, Bakowska-Barczak AM, Kolodziejczyk P, Ryu OH, Choi MK, Kang YH, Lim SS, Suh HW, Huh SO, Lee JY
- KMID: 2170674
- Biomol Ther.
- 2013 Jul;21(4):284-289.
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin... -
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- Silymarin's Protective Effects and Possible Mechanisms on Alcoholic Fatty Liver for Rats
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Zhang W, Hong R, Tian T
- KMID: 2170671
- Biomol Ther.
- 2013 Jul;21(4):264-269.
Silymarin has been introduced fairly recently as a hepatoprotective agent. But its mechanisms of action still have not been well established. The aim of this study was to make alcoholic... -
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- Chronic Administration of Catechin Decreases Depression and Anxiety-Like Behaviors in a Rat Model Using Chronic Corticosterone Injections
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Lee B, Sur B, Kwon S, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2170678
- Biomol Ther.
- 2013 Jul;21(4):313-322.
Previous studies have demonstrated that repeated administration of the exogenous stress hormone corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis and results in depression and anxiety. The current study... -
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- Effects of Calcium Gluconate, a Water Soluble Calcium Salt on the Collagen-Induced DBA/1J Mice Rheumatoid Arthritis
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Sohn KC, Kang SJ, Kim JW, Kim KY, Ku SK, Lee YJ
- KMID: 2170675
- Biomol Ther.
- 2013 Jul;21(4):290-298.
This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered... -
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- Ethanolic Extract of the Seed of Zizyphus jujuba var. spinosa Ameliorates Cognitive Impairment Induced by Cholinergic Blockade in Mice
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Lee HE, Lee SY, Kim JS, Park SJ, Kim JM, Lee YW, Jung JM, Kim DH, Shin BY, Jang DS, Kang SS, Ryu JH
- KMID: 2170676
- Biomol Ther.
- 2013 Jul;21(4):299-306.
In the present study, we investigated the effect of ethanolic extract of the seed of Zizyphus jujuba var. spinosa (EEZS) on cholinergic blockade-induced memory impairment in mice. Male ICR mice... -
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