- Emerging Roles of Human Prostatic Acid Phosphatase
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Kong HY, Byun J
- KMID: 2170680
- Biomol Ther.
- 2013 Jan;21(1):10-20.
Prostate cancer is one of the most prevalent non-skin related cancers. It is the second leading cause of cancer deaths among males in most Western countries. If prostate cancer is... -
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- Metformin Suppresses MHC-Restricted Antigen Presentation by Inhibiting Co-Stimulatory Factors and MHC Molecules in APCs
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Shin S, Hyun B, Lee A, Kong H, Han S, Lee CK, Ha NJ, Kim K
- KMID: 2170683
- Biomol Ther.
- 2013 Jan;21(1):35-41.
Metformin is widely used for T2D therapy but its cellular mechanism of action is undefined. Recent studies on the mechanism of metformin in T2D have demonstrated involvement of the immune... -
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- Antidepressant-Like Effects of Lycii Radicis Cortex and Betaine in the Forced Swimming Test in Rats
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Kim SJ, Lee MS, Kim JH, Lee TH, Shim I
- KMID: 2170690
- Biomol Ther.
- 2013 Jan;21(1):79-83.
The purpose of the present study was to examine the effect of Lycii Radicis Cortex (LRC) and betaine (BT) on immobility and neurochemical change in the forced swimming test (FST)... -
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- Inhibition of Experimental Systemic Inflammation (Septic Inflammation) and Chronic Bronchitis by New Phytoformula BL Containing Broussonetia papyrifera and Lonicera japonica
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Ko HJ, Kwon OS, Jin JH, Son KH, Kim HP
- KMID: 2170688
- Biomol Ther.
- 2013 Jan;21(1):66-71.
Broussonetia papyrifera and Lonicera japonica have long been used in the treatment of inflammatory disorders in Chinese medicine, especially respiratory inflammation. Previously, a new phytoformula (BL) containing B. papyrifera and... -
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- The Cholesterol-Binding Antibiotic Nystatin Induces Expression of Macrophage Inflammatory Protein-1 in Macrophages
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Baek S, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K
- KMID: 2170684
- Biomol Ther.
- 2013 Jan;21(1):42-48.
Nystatin, a polyene antifungal antibiotic, is a cholesterol sequestering agent. The antifungal agent alters composition of the plasma membrane of eukaryotic cells, whereas its effects on cells are poorly investigated.... -
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- Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence
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Yun DK, Lee J, Keum YS
- KMID: 2170685
- Biomol Ther.
- 2013 Jan;21(1):49-53.
A number of naturally-occurring or synthetic chemicals have been reported to exhibit prostate chemopreventive effects. Synthetic 5alpha-reductase (5-AR) inhibitors, e.g. finasteride and durasteride, gained special interests as possible prostate chemopreventive... -
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- Inhibitory Effects of Epigallocatechin-3-Gallate on Microsomal Cyclooxygenase-1 Activity in Platelets
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Lee DH, Kim YJ, Kim HH, Cho HJ, Ryu JH, Rhee MH, Park HJ
- KMID: 2170686
- Biomol Ther.
- 2013 Jan;21(1):54-59.
In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins from green tea leaves, on activities of cyclooxygenase (COX)-1 and thromboxane synthase (TXAS),... -
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- Histopathological Evaluation of Heart Toxicity of a Novel Selective PPAR-gamma Agonists CKD-501 in db/db Mice
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Yang HI, Kim WS, Kim DH, Kang JS
- KMID: 2170691
- Biomol Ther.
- 2013 Jan;21(1):84-88.
High risk of cardiovascular diseases caused by existing PPAR-gamma agonists such as rosiglitazone and pioglitazone has been recently reported. CKD-501 is a novel selective PPAR-gamma agonist as a potential target... -
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- Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells
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Han HE, Kim TK, Son HJ, Park WJ, Han PL
- KMID: 2170681
- Biomol Ther.
- 2013 Jan;21(1):21-28.
Microglia play a role in maintaining and resolving brain tissue homeostasis. In pathological conditions, microglia release pro-inflammatory cytokines and cytotoxic factors, which aggravate the progression of neurodegenerative diseases. Autophagy pathway... -
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- 3,4,5-Trihydroxycinnamic Acid Inhibits Lipopolysaccharide-Induced Inflammatory Response through the Activation of Nrf2 Pathway in BV2 Microglial Cells
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Lee JW, Choi YJ, Park JH, Sim JY, Kwon YS, Lee HJ, Kim SS, Chun W
- KMID: 2170687
- Biomol Ther.
- 2013 Jan;21(1):60-65.
3,4,5-Trihydroxycinnamic acid (THC) is a derivative of hydroxycinnamic acids, which have been reported to possess a variety of biological properties such as anti-inflammatory, anti-tumor, and neuroprotective activities. However, biological activity... -
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- Polyamines and Their Metabolites as Diagnostic Markers of Human Diseases
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Park MH, Igarashi K
- KMID: 2170679
- Biomol Ther.
- 2013 Jan;21(1):1-9.
Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are essential for eukaryotic cell growth. These polycations interact with negatively charged molecules such as DNA, RNA, acidic proteins... -
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- Anti-Inflammatory, Antioxidant, Anti-Angiogenic and Skin Whitening Activities of Phryma leptostachya var. asiatica Hara Extract
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Jung HJ, Cho YW, Lim HW, Choi H, Ji DJ, Lim CJ
- KMID: 2170689
- Biomol Ther.
- 2013 Jan;21(1):72-78.
This work aimed to assess some pharmacological activities of P. leptostachya var. asiatica Hara. The dried roots of P. leptostachya var. asiatica Hara were extracted with 70% ethanol to generate... -
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- Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis
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Park SH, Park SJ, Kim JO, Shin JH, Kim ES, Jo YK, Kim JS, Park SJ, Jin DH, Hwang JJ, Lee SJ, Jeong SY, Lee C, Kim I, Cho DH
- KMID: 2170682
- Biomol Ther.
- 2013 Jan;21(1):29-34.
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor family of cytokines. TRAIL selectively induces apoptotic cell death in various tumors and cancer... -
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