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Toluene Inhalation Causes Early Anxiety and Delayed Depression with Regulation of Dopamine Turnover, 5-HT1A Receptor, and Adult Neurogenesis in Mice

Kim J, Lim J, Moon SH, Liu KH, Choi HJ

  • Biomol Ther.
  • 2020 May;28(3):282-291.
  • doi: 10.4062/biomolther.2020.055
Inhaled solvents such as toluene are of particular concern due to their abuse potential that is easily exposed to the environment. The inhalation of toluene causes various behavioral problems, but,...
A 3D “In Vitro” Model to Study Hyaluronan Effect in Nasal Epithelial Cell Line Exposed to Double-Stranded RNA Poly(I:C)

Albano GD, Bonanno A, Giacomazza D, Cavalieri , Sammarco M, Ingrassia , Gagliardo , Riccobono , Moscato M, Anzalone G, Montalbano AM, Profita M

  • Biomol Ther.
  • 2020 May;28(3):272-281.
  • doi: 10.4062/biomolther.2019.126
Environmental agents, including viral and bacterial infectious agents, are involved in the alteration of physicochemical and biological parameters in the nasal epithelium. Hyaluronan (HA) has an important role in the...
FFA2 Activation Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

Kang J, Im DS

  • Biomol Ther.
  • 2020 May;28(3):267-271.
  • doi: 10.4062/biomolther.2019.160
Gut microbiota produce dietary metabolites such as short-chain fatty acids, which exhibit anti-inflammatory effects. Free fatty acid receptor 2 (FFA2, formerly known as GPR43) is a specific receptor for short-chain...
Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway

Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y

  • Biomol Ther.
  • 2020 May;28(3):259-266.
  • doi: 10.4062/biomolther.2019.123
The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid...
LJ-2698, an Adenosine A3 Receptor Antagonist, Alleviates Elastase-Induced Pulmonary Emphysema in Mice

Boo HJ, Park SJ, Noh M, Min HY, Jeong LS, Lee HY

  • Biomol Ther.
  • 2020 May;28(3):250-258.
  • doi: 10.4062/biomolther.2019.162
Emphysema, a major component of chronic obstructive pulmonary disease (COPD), is a leading cause of human death worldwide. The progressive deterioration of lung function that occurs in the disease is...
Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia

Lee JH, Han YS, Lee SH

  • Biomol Ther.
  • 2020 May;28(3):240-249.
  • doi: 10.4062/biomolther.2019.131
Despite the therapeutic effect of mesenchymal stem cells (MSCs) in ischemic diseases, pathophysiological conditions, including hypoxia, limited nutrient availability, and oxidative stress restrict their potential. To address this issue, we...
Imipramine Ameliorates Depressive Symptoms by Blocking Differential Alteration of Dendritic Spine Structure in Amygdala and Prefrontal Cortex of Chronic Stress-Induced Mice

Leem YH, Yoon SS, Jo SA

  • Biomol Ther.
  • 2020 May;28(3):230-239.
  • doi: 10.4062/biomolther.2019.152
Previous studies have shown disrupted synaptic plasticity and neural activity in depression. Such alteration is strongly associated with disrupted synaptic structures. Chronic stress has been known to induce changes in...
Repositioned Drugs for Inflammatory Diseases such as Sepsis, Asthma, and Atopic Dermatitis

Prakash AV, Park JW, Seong JW, Kang TJ

  • Biomol Ther.
  • 2020 May;28(3):222-229.
  • doi: 10.4062/biomolther.2020.001
The process of drug discovery and drug development consumes billions of dollars to bring a new drug to the market. Drug development is time consuming and sometimes, the failure rates...
Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury

Uddin MJ, Dorotea D, Pak ES, Ha H

  • Biomol Ther.
  • 2020 May;28(3):213-221.
  • doi: 10.4062/biomolther.2019.214
Acute kidney injury (AKI) is a common disease with a complex pathophysiology which significantly contributes to the development of chronic kidney disease and end stage kidney failure. Preventing AKI can...

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