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Novel Isoquinolinamine and Isoindoloquinazolinone Compounds Exhibit Antiproliferative Activity in Acute Lymphoblastic Leukemia Cells

Roolf C, Saleweski , Stein A, Richter A, Maletzki C, Sekora A, Escobar HM, Wu XF, Beller M, Junghanss

  • Biomol Ther.
  • 2019 Sep;27(5):492-501.
  • doi: 10.4062/biomolther.2018.199
Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified...
Curcumin-Induced Autophagy Augments Its Antitumor Effect against A172 Human Glioblastoma Cells

Lee JE, Yoon SS, Moon EY

  • Biomol Ther.
  • 2019 Sep;27(5):484-491.
  • doi: 10.4062/biomolther.2019.107
Glioblastoma is the most aggressive common brain tumor in adults. Curcumin, from Curcuma longa, is an effective antitumor agent. Although the same proteins control both autophagy and cell death, the...
Arg-Leu-Tyr-Glu Suppresses Retinal Endothelial Permeability and Choroidal Neovascularization by Inhibiting the VEGF Receptor 2 Signaling Pathway

Park W, Baek YY, Kim J, Jo DH, Choi S, Kim JH, Kim T, Kim S, Park M, Kim JY, Won MH, Ha KS, Kim JH, Kwon YG, Kim YM

  • Biomol Ther.
  • 2019 Sep;27(5):474-483.
  • doi: 10.4062/biomolther.2019.041
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the...
Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses

Thapa B, Pak S, Kwon HJ, Lee K

  • Biomol Ther.
  • 2019 Sep;27(5):466-473.
  • doi: 10.4062/biomolther.2019.004
Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, the bioactive compounds of...
Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model

Kim M, Jeong H, Lee B, Cho Y, Yoon WK, Cho A, Kwon G, Nam KT, Ha H, Lim KM

  • Biomol Ther.
  • 2019 Sep;27(5):457-465.
  • doi: 10.4062/biomolther.2018.214
Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in...
Anxiolytic Action of Taurine via Intranasal Administration in Mice

Jung JH, Kim SJ

  • Biomol Ther.
  • 2019 Sep;27(5):450-456.
  • doi: 10.4062/biomolther.2018.218
Taurine has a number of beneficial pharmacological actions in the brain such as anxiolytic and neuroprotective actions. We explored to test whether taurine could be transported to the central nervous...
Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production

Chen D, Zhang XY, Sun J, Cong QJ, Chen WX, Ahsan HM, Gao J, Qian JJ

  • Biomol Ther.
  • 2019 Sep;27(5):442-449.
  • doi: 10.4062/biomolther.2018.188
This study sought to evaluate the effects of Asiatic acid in LPS-induced BV2 microglia cells and 1-methyl-4-phenyl-pyridine (MPP⁺)-induced SH-SY5Y cells, to investigate the potential anti-inflammatory mechanisms of Asiatic acid in...
Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level

Pearce LV, Ann J, Blumberg P, Lee J

  • Biomol Ther.
  • 2019 Sep;27(5):435-441.
  • doi: 10.4062/biomolther.2019.013
The capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) has been an object of intense interest for pharmacological development on account of its critical role in nociception. In the course...
Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage

Park S, Park JA, Jeon JH, Lee Y

  • Biomol Ther.
  • 2019 Sep;27(5):423-434.
  • doi: 10.4062/biomolther.2019.051
HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in...

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