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Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress

Kim J, Kim J, Huang Z, Goo N, Bae HJ, Jeong Y, Park HJ, Cai M, Cho K, Jung SY, Bae SK, Ryu JH

  • Biomol Ther.
  • 2019 May;27(3):327-335.
  • doi: 10.4062/biomolther.2019.046
As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials...
Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1Pâ‚‚) Attenuates Bleomycin-Induced Pulmonary Fibrosis

Park SJ, Im DS

  • Biomol Ther.
  • 2019 May;27(3):318-326.
  • doi: 10.4062/biomolther.2018.131
Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum, bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and experimental mouse models. Although the roles of...
An Anti-Cancer Drug Candidate CYC116 Suppresses Type I Hypersensitive Immune Responses through the Inhibition of Fyn Kinase in Mast Cells

Park YH, Kim HW, Kim HS, Nam ST, Lee D, Lee MB, Min KY, Koo J, Kim SJ, Kim YM, Kim HS, Choi WS

  • Biomol Ther.
  • 2019 May;27(3):311-317.
  • doi: 10.4062/biomolther.2018.148
Mast cells are the most prominent effector cells of Type 1 hypersensitivity immune responses. CYC116 [4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl] pyrimidin-2-amine] is under development to be used as an anti-cancer drug, but the inhibitory...
Differential Gene Expression Common to Acquired and Intrinsic Resistance to BRAF Inhibitor Revealed by RNA-Seq Analysis

Ahn JH, Hwang SH, Cho HS, Lee M

  • Biomol Ther.
  • 2019 May;27(3):302-310.
  • doi: 10.4062/biomolther.2018.133
Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P)...
Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier

Gyawali A, Krol S, Kang YS

  • Biomol Ther.
  • 2019 May;27(3):290-301.
  • doi: 10.4062/biomolther.2019.007
Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of...
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes

Bang M, Ryu O, Kim DG, Mabunga DF, Cho KS, Kim Y, Han SH, Kwon KJ, Shin CY

  • Biomol Ther.
  • 2019 May;27(3):283-289.
  • doi: 10.4062/biomolther.2018.107
Brain aging induces neuropsychological changes, such as decreased memory capacity, language ability, and attention; and is also associated with neurodegenerative diseases. However, most of the studies on brain aging are...
Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein

Chun YS, Kwon OH, Oh HG, Cho YY, Yang HO, Chung S

  • Biomol Ther.
  • 2019 May;27(3):276-282.
  • doi: 10.4062/biomolther.2018.112
β-amyloid precursor protein (APP) can be cleaved by α-, and γ-secretase at plasma membrane producing soluble ectodomain fragment (sAPPα). Alternatively, following endocytosis, APP is cleaved by β-, and γ-secretase at...
Possible Effects of Radiofrequency Electromagnetic Field Exposure on Central Nerve System

Kim JH, Lee JK, Kim HG, Kim KB, Kim HR

  • Biomol Ther.
  • 2019 May;27(3):265-275.
  • doi: 10.4062/biomolther.2018.152
Technological advances of mankind, through the development of electrical and communication technologies, have resulted in the exposure to artificial electromagnetic fields (EMF). Technological growth is expected to continue; as such,...
Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of Action

Kim JY, Shim SH

  • Biomol Ther.
  • 2019 May;27(3):254-264.
  • doi: 10.4062/biomolther.2018.231
Atherosclerosis is a widespread and chronic progressive arterial disease that has been regarded as one of the major causes of death worldwide. It is caused by the deposition of cholesterol,...
Flavonoids: Broad Spectrum Agents on Chronic Inflammation

Lim H, Heo MY, Kim HP

  • Biomol Ther.
  • 2019 May;27(3):241-253.
  • doi: 10.4062/biomolther.2019.034
Flavonoids are major plant constituents with numerous biological/pharmacological actions both in vitro and in vivo. Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory...

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