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Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2

Li T, Wan Y, Sun L, Tao S, Chen P, Liu C, Wang K, Zhou C, Zhao G

  • Biomol Ther.
  • 2019 Jul;27(4):414-422.
  • doi: 10.4062/biomolther.2018.073
There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in...
Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells

Choi N, Sung JH

  • Biomol Ther.
  • 2019 Jul;27(4):404-413.
  • doi: 10.4062/biomolther.2018.195
Udenafil, which is a PDE5 inhibitor, is used to treat erectile dysfunction. However, it is unclear whether udenafil induces hair growth via the stimulation of adipose-derived stem cells (ASCs). In...
Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5

Zhen AX, Piao MJ, Hyun YJ, Kang KA, Ryu YS, Cho SJ, Kang HK, Koh YS, Ahn MJ, Kim TH, Hyun JW

  • Biomol Ther.
  • 2019 Jul;27(4):395-403.
  • doi: 10.4062/biomolther.2018.151
Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis...
Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model

Ayyappan J, lizardo K, Wang S, Yurkow E, Nagajyothi JF

  • Biomol Ther.
  • 2019 Jul;27(4):386-394.
  • doi: 10.4062/biomolther.2018.193
Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM)...
4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages

Yoo OK, Keum YS

  • Biomol Ther.
  • 2019 Jul;27(4):381-385.
  • doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage...
Pro-Inflammatory Role of S1P₃ in Macrophages

Heo JY, Im DS

  • Biomol Ther.
  • 2019 Jul;27(4):373-380.
  • doi: 10.4062/biomolther.2018.215
Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors S1P₁ and S1P₂ on cell motility...
7,8,4′-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells

Ko YH, Kim SK, Kwon SH, Seo JY, Lee BR, Kim YJ, Hur KH, Kim SY, Lee SY, Jang CG

  • Biomol Ther.
  • 2019 Jul;27(4):363-372.
  • doi: 10.4062/biomolther.2018.211
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4′-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine...
Limonene Inhibits Methamphetamine-Induced Sensitizations via the Regulation of Dopamine Receptor Supersensitivity

Gu SM, Kim SY, Lamichhane S, Hong JT, Yun J

  • Biomol Ther.
  • 2019 Jul;27(4):357-362.
  • doi: 10.4062/biomolther.2018.213
Limonene is a cyclic terpene found in citrus essential oils and inhibits methamphetamine-induced locomotor activity. Drug dependence is a severe neuropsychiatric condition that depends in part on changes in neurotransmission...
Comparative Behavioral Correlation of High and Low-Performing Mice in the Forced Swim Test

Valencia S, Gonzales E, Adil KJ, Jeon SJ, Kwon KJ, Cho KS, Shin CY

  • Biomol Ther.
  • 2019 Jul;27(4):349-356.
  • doi: 10.4062/biomolther.2018.210
Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but...
Molecular Pathophysiology of Ossification of the Posterior Longitudinal Ligament (OPLL)

Nam DC, Lee HJ, Lee CJ, Hwang SC

  • Biomol Ther.
  • 2019 Jul;27(4):342-348.
  • doi: 10.4062/biomolther.2019.043
Ossification of the posterior longitudinal ligament (OPLL) can be defined as an ectopic ossification in the tissues of spinal ligament showing a hyperostotic condition. OPLL is developed mostly in the...
Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer

Ko JY, Lee EJ, Park JH

  • Biomol Ther.
  • 2019 Jul;27(4):337-341.
  • doi: 10.4062/biomolther.2019.056
Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between...

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