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Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells

Sung SJ, Kim HK, Hong YK, Joe YA

  • Biomol Ther.
  • 2019 Jan;27(1):117-125.
  • doi: 10.4062/biomolther.2018.222
Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the...
Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice

Kim S, Song NJ, Chang SH, Bahn G, Choi Y, Rhee DK, Yun UJ, Choi J, Lee J, Yoo JH, Shin D, Park KM, Kang H, Lee S, Ku JM, Cho YS, Park KW

  • Biomol Ther.
  • 2019 Jan;27(1):107-116.
  • doi: 10.4062/biomolther.2018.090
The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes...
The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat

Han JS, Kim SJ, Nam Y, Lee HY, Kim GM, Kim DM, Sohn UD

  • Biomol Ther.
  • 2019 Jan;27(1):101-106.
  • doi: 10.4062/biomolther.2018.136
Most diabetic patients experience diabetic mellitus (DM) urinary bladder dysfunction. A number of studies evaluate bladder smooth muscle contraction in DM. In this study, we evaluated the change of bladder...
Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway

Zhao D, Gu MY, Xu JL, Zhang LJ, Ryu SY, Yang HO

  • Biomol Ther.
  • 2019 Jan;27(1):92-100.
  • doi: 10.4062/biomolther.2018.104
Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this...
7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress

Cho SJ, Kang KA, Piao MJ, Ryu YS, Fernando P, Zhen AX, Hyun YJ, Ahn MJ, Kang HK, Hyun JW

  • Biomol Ther.
  • 2019 Jan;27(1):85-91.
  • doi: 10.4062/biomolther.2018.202
Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent...
Cell Surface Antigen Display for Neuronal Differentiation-Specific Tracking

Kim SC, Lee EH, Yu JH, Kim SM, Nam BG, Chung HY, Kim YS, Cho SR, Park CH

  • Biomol Ther.
  • 2019 Jan;27(1):78-84.
  • doi: 10.4062/biomolther.2018.110
Cell therapeutic agents for treating degenerative brain diseases using neural stem cells are actively being developed. However, few systems have been developed to monitor in real time whether the transplanted...
Neuroprotective Effects of Spinosin on Recovery of Learning and Memory in a Mouse Model of Alzheimer's Disease

Xu F, He B, Xiao F, Yan T, Bi K, Jia Y, Wang Z

  • Biomol Ther.
  • 2019 Jan;27(1):71-77.
  • doi: 10.4062/biomolther.2018.051
Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this...
Analysis of the Expression and Regulation of PD-1 Protein on the Surface of Myeloid-Derived Suppressor Cells (MDSCs)

Nam S, Lee A, Lim J, Lim JS

  • Biomol Ther.
  • 2019 Jan;27(1):63-70.
  • doi: 10.4062/biomolther.2018.201
Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as...
Cis-3-O-p-hydroxycinnamoyl Ursolic Acid Induced ROS-Dependent p53-Mediated Mitochondrial Apoptosis in Oral Cancer Cells

Wang CY, Lin CS, Hua CH, Jou YJ, Liao CR, Chang YS, Wan L, Huang SH, Hour MJ, Lin CW

  • Biomol Ther.
  • 2019 Jan;27(1):54-62.
  • doi: 10.4062/biomolther.2017.237
Cis-3-O-p-hydroxycinnamoyl ursolic acid (HCUA), a triterpenoid compound, was purified from Elaeagnus oldhamii Maxim. This traditional medicinal plant has been used for treating rheumatoid arthritis and lung disorders as well as...
MS-5, a Naphthalene Derivative, Induces the Apoptosis of an Ovarian Cancer Cell CAOV-3 by Interfering with the Reactive Oxygen Species Generation

Ma E, Jeong SJ, Choi JS, Nguyen TH, Jeong CH, Joo SH

  • Biomol Ther.
  • 2019 Jan;27(1):48-53.
  • doi: 10.4062/biomolther.2018.020
Reactive oxygen species (ROS) are widely generated in biological processes such as normal metabolism and response to xenobiotic exposure. While ROS can be beneficial or harmful to cells and tissues,...
Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways

Han X, Kang KA, Piao MJ, Zhen AX, Hyun YJ, Kim HM, Ryu YS, Hyun JW

  • Biomol Ther.
  • 2019 Jan;27(1):41-47.
  • doi: 10.4062/biomolther.2018.047
The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated...
Transglutaminase 2 Promotes Autophagy by LC3 Induction through p53 Depletion in Cancer Cell

Kang JH, Lee SH, Cheong H, Lee CH, Kim SY

  • Biomol Ther.
  • 2019 Jan;27(1):34-40.
  • doi: 10.4062/biomolther.2018.140
Transglutaminase 2 (TGase 2) plays a key role in p53 regulation, depleting p53 tumor suppressor through autophagy in renal cell carcinoma. We found that microtubule-associated protein 1A/1B-light chain 3 (LC3),...
Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

Ayala-Cuellar AP, Kang JH, Jeung EB, Choi KC

  • Biomol Ther.
  • 2019 Jan;27(1):25-33.
  • doi: 10.4062/biomolther.2017.260
Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially...
Regulation of Neural Stem Cell Fate by Natural Products

Kim HJ

  • Biomol Ther.
  • 2019 Jan;27(1):15-24.
  • doi: 10.4062/biomolther.2018.184
Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent...
Resveratrol: Twenty Years of Growth, Development and Controversy

Pezzuto JM

  • Biomol Ther.
  • 2019 Jan;27(1):1-14.
  • doi: 10.4062/biomolther.2018.176
Resveratrol was first isolated in 1939 by Takaoka from Veratrum grandiflorum O. Loes. Following this discovery, sporadic descriptive reports appeared in the literature. However, spurred by our seminal paper published...

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