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Effects of Several Cosmetic Preservatives on ROS-Dependent Apoptosis of Rat Neural Progenitor Cells

Ryu O, Park BK, Bang M, Cho KS, Lee SH, Gonzales E, Yang SM, Kim S, Eun PH, Lee JY, Kim KB, Shin CY, Kwon KJ

  • Biomol Ther.
  • 2018 Nov;26(6):608-615.
  • doi: 10.4062/biomolther.2017.221
Benzalkonium chloride, diazolidinyl urea, and imidazolidinyl urea are commonly used preservatives in cosmetics. Recent reports suggested that these compounds may have cellular and systemic toxicity in high concentration. In addition,...
Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner

Kim M, Gu GJ, Koh YS, Lee SH, Na YR, Seok SH, Lim KM

  • Biomol Ther.
  • 2018 Nov;26(6):599-607.
  • doi: 10.4062/biomolther.2017.225
Fasiglifam (TAK-875) a G-protein coupled receptor 40 (GPR40) agonist, significantly improves hyperglycemia without hypoglycemia and weight gain, the major side effects of conventional anti-diabetics. Unfortunately, during multi-center Phase 3 clinical...
Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells

Park JK, Seo JS, Lee SK, Chan KK, Kuh HJ

  • Biomol Ther.
  • 2018 Nov;26(6):591-598.
  • doi: 10.4062/biomolther.2018.061
Epigenetic silencing is considered to be a major mechanism for loss of activity in tumor suppressors. Reversal of epigenetic silencing by using inhibitors of DNA methyltransferase (DNMT) or histone deacetylases...
Cytoprotective Effect of Taurine against Hydrogen Peroxide-Induced Oxidative Stress in UMR-106 Cells through the Wnt/β-Catenin Signaling Pathway

Lou J, Han D, Yu H, Yu G, Jin M, Kim SJ

  • Biomol Ther.
  • 2018 Nov;26(6):584-590.
  • doi: 10.4062/biomolther.2018.049
Osteoporosis development is closely associated with oxidative stress and reactive oxygen species (ROS). Taurine has potential antioxidant effects, but its role in osteoblasts is not clearly understood. The aim of...
Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection

Song JH, Shim A, Kim YJ, Ahn JH, Kwon BE, Pham TT, Lee J, Chang SY, Ko HJ

  • Biomol Ther.
  • 2018 Nov;26(6):576-583.
  • doi: 10.4062/biomolther.2017.233
Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular...
Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans

Lee EB, Kim JH, An CW, Kim YJ, Noh YJ, Kim SJ, Kim JE, Shrestha A, Ham HN, Leem JY, Jo HK, Kim DS, Moon KH, Lee JH, Jeong KO, Kim DK

  • Biomol Ther.
  • 2018 Nov;26(6):568-575.
  • doi: 10.4062/biomolther.2017.215
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The...
Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway

Kang DG, Lee HJ, Lee CJ, Park JS

  • Biomol Ther.
  • 2018 Nov;26(6):560-567.
  • doi: 10.4062/biomolther.2018.132
In the present study, we tried to examine whether resveratrol regulates the expression of matrix metalloproteinases (MMPs) through affecting nuclear factor-kappa B (NF-κB) in articular chondrocytes. Rabbit articular chondrocytes were...
Therapeutic Potential of the Rhizomes of Anemarrhena asphodeloides and Timosaponin A-III in an Animal Model of Lipopolysaccharide-Induced Lung Inflammation

Park BK, So KS, Ko HJ, Kim HJ, Kwon KS, Kwon YS, Son KH, Kwon SY, Kim HP

  • Biomol Ther.
  • 2018 Nov;26(6):553-559.
  • doi: 10.4062/biomolther.2017.249
Investigations into the development of new therapeutic agents for lung inflammatory disorders have led to the discovery of plant-based alternatives. The rhizomes of Anemarrhena asphodeloides have a long history of...
Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells

Lee DK, Min YS, Yoo SS, Shim HS, Park SY, Sohn UD

  • Biomol Ther.
  • 2018 Nov;26(6):546-552.
  • doi: 10.4062/biomolther.2018.053
A comprehensive collection of proteins senses local changes in intracellular Ca²⁺ concentrations ([Ca²⁺](i) and transduces these signals into responses to agonists. In the present study, we examined the effect of...
Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma

Huang J, Su M, Lee BK, Kim MJ, Jung JH, Im DS

  • Biomol Ther.
  • 2018 Nov;26(6):539-545.
  • doi: 10.4062/biomolther.2018.006
4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione (PD1) is a synthetic phthalimide derivative of a marine compound. PD1 has peroxisome proliferator-activated receptor (PPAR) γ agonistic and anti-inflammatory effects. This study aimed to investigate the effect of...
Pathophysiological Role of S-Nitrosylation and Transnitrosylation Depending on S-Nitrosoglutathione Levels Regulated by S-Nitrosoglutathione Reductase

Choi MS

  • Biomol Ther.
  • 2018 Nov;26(6):533-538.
  • doi: 10.4062/biomolther.2018.179
Nitric oxide (NO) mediates various physiological and pathological processes, including cell proliferation, differentiation, and inflammation. Protein S-nitrosylation (SNO), a NO-mediated reversible protein modification, leads to changes in the activity and...
Sex Differences in Cardiovascular Risk Factors for Dementia

Kim MY, Kim K, Hong CH, Lee SY, Jung YS

  • Biomol Ther.
  • 2018 Nov;26(6):521-532.
  • doi: 10.4062/biomolther.2018.159
Dementia, characterized by a progressive cognitive decline and a cumulative inability to behave independently, is highly associated with other diseases. Various cardiovascular disorders, such as coronary artery disease and atrial...

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