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Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells

Liu Q, Cao Y, Zhou P, Gui S, Wu X, Xia Y, Tu J

  • Biomol Ther.
  • 2018 May;26(3):328-334.
  • doi: 10.4062/biomolther.2017.042
Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary...
Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1

Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Kwon HJ

  • Biomol Ther.
  • 2018 May;26(3):322-327.
  • doi: 10.4062/biomolther.2017.235
A type of breast cancer with a defect in three molecular markers such as the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor is called triple-negative breast cancer...
Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway

Lee JH, Yun CW, Lee SH

  • Biomol Ther.
  • 2018 May;26(3):313-321.
  • doi: 10.4062/biomolther.2017.033
Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive....
Development of S-Methylmethionine Sulfonium Derivatives and Their Skin-Protective Effect against Ultraviolet Exposure

Kim WS, Kim WK, Choi N, Suh W, Lee J, Kim DD, Kim I, Sung JH

  • Biomol Ther.
  • 2018 May;26(3):306-312.
  • doi: 10.4062/biomolther.2017.109
In a previous study, we have demonstrated that S-methylmethionine sulfonium (SMMS) confers wound-healing and photoprotective effects on the skin, suggesting that SMMS can be used as a cosmetic raw material....
Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse

Lee MY, Kang JS, Go RE, Byun YS, Wi YJ, Hwang KA, Choi JH, Kim HC, Choi KC, Nam KH

  • Biomol Ther.
  • 2018 May;26(3):298-305.
  • doi: 10.4062/biomolther.2017.103
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α)...
Construction of a Transcriptome-Driven Network at the Early Stage of Infection with Influenza A H1N1 in Human Lung Alveolar Epithelial Cells

Chung M, Cho SY, Lee YS

  • Biomol Ther.
  • 2018 May;26(3):290-297.
  • doi: 10.4062/biomolther.2017.240
We aimed to understand the molecular changes in host cells that accompany infection by the seasonal influenza A H1N1 virus because the initial response rapidly changes owing to the fact...
Designing Tyrosinase siRNAs by Multiple Prediction Algorithms and Evaluation of Their Anti-Melanogenic Effects

Kwon OS, Kwon SJ, Kim JS, Lee G, Maeng HJ, Lee J, Hwang GS, Cha HJ, Chun KH

  • Biomol Ther.
  • 2018 May;26(3):282-289.
  • doi: 10.4062/biomolther.2017.115
Melanin is a pigment produced from tyrosine in melanocytes. Although melanin has a protective role against UVB radiation-induced damage, it is also associated with the development of melanoma and darker...
The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents

Shin CY, Kim HS, Cha KH, Won DH, Lee JY, Jang SW, Sohn UD

  • Biomol Ther.
  • 2018 May;26(3):274-281.
  • doi: 10.4062/biomolther.2017.189
A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. This study...
Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression

Yayeh T, Leem YH, Kim KM, Jung JC, Schwarz J, Oh KW, Oh S

  • Biomol Ther.
  • 2018 May;26(3):268-273.
  • doi: 10.4062/biomolther.2017.083
Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of α(S1)-casein (α(S1)-CH) has been...
Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception

Choi SI, Hwang SW

  • Biomol Ther.
  • 2018 May;26(3):255-267.
  • doi: 10.4062/biomolther.2017.127
Inflammation is one of the main causes of pathologic pain. Knowledge of the molecular links between inflammatory signals and pain-mediating neuronal signals is essential for understanding the mechanisms behind pain...
Towards the Application of Human Defensins as Antivirals

Park MS, Kim JI, Lee I, Park S, Bae JY, Park MS

  • Biomol Ther.
  • 2018 May;26(3):242-254.
  • doi: 10.4062/biomolther.2017.172
Defensins are antimicrobial peptides that participate in the innate immunity of hosts. Humans constitutively and/or inducibly express α- and β-defensins, which are known for their antiviral and antibacterial activities. This...
Effects and Mechanisms of Taurine as a Therapeutic Agent

Schaffer S, Kim HW

  • Biomol Ther.
  • 2018 May;26(3):225-241.
  • doi: 10.4062/biomolther.2017.251
Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking...

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