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IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β

Lee H, Cheong KA, Kim JY, Kim NH, Noh M, Lee AY

  • Biomol Ther.
  • 2018 Jul;26(4):417-423.
  • doi: 10.4062/biomolther.2017.167
Extracellular interleukin 1 alpha (IL-1α) released from keratinocytes is one of the endpoints for in vitro assessments of skin irritancy. Although cells dying via primary skin irritation undergo apoptosis as...
Anti-Proliferative Activities of Vasicinone on Lung Carcinoma Cells Mediated via Activation of Both Mitochondria-Dependent and Independent Pathways

Dey T, Dutta P, Manna P, Kalita J, Boruah HP, Buragohain AK, Unni B

  • Biomol Ther.
  • 2018 Jul;26(4):409-416.
  • doi: 10.4062/biomolther.2017.097
Vasicinone, a quinazoline alkaloid from Adhatoda vasica Nees. is well known for its bronchodilator activity. However its antiproliferative activities is yet to be elucidated. Here-in we investigated the anti-proliferative effect...
Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets

Nagashima , Nishiyama , Iwao B, Kawai Y, Ishii C, Yamanaka T, Uchino H, Inazu M

  • Biomol Ther.
  • 2018 Jul;26(4):399-408.
  • doi: 10.4062/biomolther.2017.113
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the...
Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy

Yun SP, Han YS, Lee JH, Kim SM, Lee SH

  • Biomol Ther.
  • 2018 Jul;26(4):389-398.
  • doi: 10.4062/biomolther.2017.071
p-Cresol, found at high concentrations in the serum of chronic kidney failure patients, is known to cause cell senescence and other complications in different parts of the body. p-Cresol is...
Neural Stem Cell Differentiation Using Microfluidic Device-Generated Growth Factor Gradient

Kim JH, Sim J, Kim HJ

  • Biomol Ther.
  • 2018 Jul;26(4):380-388.
  • doi: 10.4062/biomolther.2018.001
Neural stem cells (NSCs) have the ability to self-renew and differentiate into multiple nervous system cell types. During embryonic development, the concentrations of soluble biological molecules have a critical role...
Endothelium Independent Effect of Pelargonidin on Vasoconstriction in Rat Aorta

Min YS, Yoon HJ, Je HD, Lee JH, Yoo SS, Shim HS, Lee HY, La HO, Sohn UD

  • Biomol Ther.
  • 2018 Jul;26(4):374-379.
  • doi: 10.4062/biomolther.2017.197
In this study, we investigated the effects of pelargonidin, an anthocyanidin found in many fruits and vegetables, on endothelium-independent vascular contractility to determine the underlying mechanism of relaxation. Isometric contractions...
Linalool Ameliorates Memory Loss and Behavioral Impairment Induced by REM-Sleep Deprivation through the Serotonergic Pathway

Lee BK, Jung AN, Jung YS

  • Biomol Ther.
  • 2018 Jul;26(4):368-373.
  • doi: 10.4062/biomolther.2018.081
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula...
Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2

Kim M, de la Peña JB, Cheong JH, Kim HJ

  • Biomol Ther.
  • 2018 Jul;26(4):358-367.
  • doi: 10.4062/biomolther.2017.131
Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the...
Phagocytic Roles of Glial Cells in Healthy and Diseased Brains

Jung YJ, Chung WS

  • Biomol Ther.
  • 2018 Jul;26(4):350-357.
  • doi: 10.4062/biomolther.2017.133
Glial cells are receiving much attention since they have been recognized as important regulators of many aspects of brain function and disease. Recent evidence has revealed that two different glial...
Sleep-Aids Derived from Natural Products

Hu Z, Oh S, Ha TW, Hong JT, Oh KW

  • Biomol Ther.
  • 2018 Jul;26(4):343-349.
  • doi: 10.4062/biomolther.2018.099
Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural...
Sex Differences in Cancer: Epidemiology, Genetics and Therapy

Kim HI, Lim H, Moon A

  • Biomol Ther.
  • 2018 Jul;26(4):335-342.
  • doi: 10.4062/biomolther.2018.103
The incidence and mortality of various cancers are associated with sex-specific disparities. Sex differences in cancer epidemiology are one of the most significant findings. Men are more prone to die...

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