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10 results

Imaging Cancer Metabolism

Momcilovic M, Shackelford DB

  • Biomol Ther.
  • 2018 Jan;26(1):81-92.
  • doi: 10.4062/biomolther.2017.220
It is widely accepted that altered metabolism contributes to cancer growth and has been described as a hallmark of cancer. Our view and understanding of cancer metabolism has expanded at...
Metabolic Signaling to Epigenetic Alterations in Cancer

Kim JA, Yeom YI

  • Biomol Ther.
  • 2018 Jan;26(1):69-80.
  • doi: 10.4062/biomolther.2017.185
Cancer cells reprogram cellular metabolism to support the malignant features of tumors, such as rapid growth and proliferation. The cancer promoting effects of metabolic reprogramming are found in many aspects:...
Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities

Jung BJ, Yoo HS, Shin S, Park YJ, Jeon SM

  • Biomol Ther.
  • 2018 Jan;26(1):57-68.
  • doi: 10.4062/biomolther.2017.195
Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their...
Oncogene-Driven Metabolic Alterations in Cancer

Min HY, Lee HY

  • Biomol Ther.
  • 2018 Jan;26(1):45-56.
  • doi: 10.4062/biomolther.2017.211
Cancer is the leading cause of human deaths worldwide. Understanding the biology underlying the evolution of cancer is important for reducing the economic and social burden of cancer. In addition...
Cancer Energy Metabolism: Shutting Power off Cancer Factory

Kim SY

  • Biomol Ther.
  • 2018 Jan;26(1):39-44.
  • doi: 10.4062/biomolther.2017.184
In 1923, Dr. Warburg had observed that tumors acidified the Ringer solution when 13 mM glucose was added, which was identified as being due to lactate. When glucose is the...
The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

Cho ES, Cha YH, Kim HS, Kim NH, Yook JI

  • Biomol Ther.
  • 2018 Jan;26(1):29-38.
  • doi: 10.4062/biomolther.2017.179
During cancer progression, cancer cells are repeatedly exposed to metabolic stress conditions in a resource-limited environment which they must escape. Increasing evidence indicates the importance of nicotinamide adenine dinucleotide phosphate...
Targeting Glutamine Metabolism for Cancer Treatment

Choi YK, Park KG

  • Biomol Ther.
  • 2018 Jan;26(1):19-28.
  • doi: 10.4062/biomolther.2017.178
Rapidly proliferating cancer cells require energy and cellular building blocks for their growth and ability to maintain redox balance. Many studies have focused on understanding how cancer cells adapt their...
A New Perspective on the Heterogeneity of Cancer Glycolysis

Neugent ML, Goodwin J, Sankaranarayanan I, Yetkin CE, Hsieh MH, Kim JW

  • Biomol Ther.
  • 2018 Jan;26(1):10-18.
  • doi: 10.4062/biomolther.2017.210
Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has...
Convergence of Cancer Metabolism and Immunity: an Overview

Van Dang C, Kim JW

  • Biomol Ther.
  • 2018 Jan;26(1):4-9.
  • doi: 10.4062/biomolther.2017.194
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence...
Cancer Metabolism: a Hope for Curing Cancer

Kim SY

  • Biomol Ther.
  • 2018 Jan;26(1):1-3.
  • doi: 10.4062/biomolther.2017.300
No abstract available.

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