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Effects of Adamantyl Derivatives on Pharmacokinetic Behavior of Paclitaxel in Rats

Kim KM, Lee K, Jang K, Moon YS, Lee HJ, Rhie SJ

  • Biomol Ther.
  • 2017 Sep;25(5):553-558.
  • doi: 10.4062/biomolther.2016.191
Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded...
Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?

Jeong JS, Nam KT, Lee B, Pamungkas , Song D, Kim M, Yu WJ, Lee J, Jee S, Park YH, Lim KM

  • Biomol Ther.
  • 2017 Sep;25(5):545-552.
  • doi: 10.4062/biomolther.2017.148
Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects...
Inhibitory Effect of Carnosol on Phthalic Anhydride-Induced Atopic Dermatitis via Inhibition of STAT3

Lee DY, Hwang CJ, Choi JY, Park MH, Song MJ, Oh KW, Son DJ, Lee SH, Han SB, Hong JT

  • Biomol Ther.
  • 2017 Sep;25(5):535-544.
  • doi: 10.4062/biomolther.2017.006
Carnosol is a phenolic antioxidant present in rosemary (Rosmarinus officinalis). It is known for anti-inflammatory effects, analgesic activity and anti-cancer effects. However, no study has been dedicated yet to its...
Oral Administration of Glycine and Leucine Dipeptides Improves Skin Hydration and Elasticity in UVB-Irradiated Hairless Mice

Park JI, Lee JE, Shin HJ, Song S, Lee WK, Hwang JS

  • Biomol Ther.
  • 2017 Sep;25(5):528-534.
  • doi: 10.4062/biomolther.2017.089
Placenta is a special organ that contains many nutrients such as growth factors, minerals, and bioactive peptides. Dipeptides of glycine and leucine are major components of porcine placenta extracts (PPE)...
A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation

Lim SY, Subedi L, Shin D, Kim CS, Lee KR, Kim SY

  • Biomol Ther.
  • 2017 Sep;25(5):519-527.
  • doi: 10.4062/biomolther.2016.224
Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative...
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis

Lim CJ, Lee YM, Kang SG, Lim HW, Shin KO, Jeong SK, Huh YH, Choi S, Kor M, Seo HS, Park BD, Park K, Ahn JK, Uchida Y, Park K

  • Biomol Ther.
  • 2017 Sep;25(5):511-518.
  • doi: 10.4062/biomolther.2017.119
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only...
Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice

Kim T, Wahyudi LD, Gonzalez F, Kim JH

  • Biomol Ther.
  • 2017 Sep;25(5):504-510.
  • doi: 10.4062/biomolther.2016.218
Inhibitor of nuclear factor kappa-B kinase beta (IKKβ) plays a critical role in cell proliferation and inflammation in various cells by activating NF-κB signaling. However, the interrelationship between peroxisome proliferator-activated...
Glucosylsphingosine Activates Serotonin Receptor 2a and 2b: Implication of a Novel Itch Signaling Pathway

Afzal R, Shim WS

  • Biomol Ther.
  • 2017 Sep;25(5):497-503.
  • doi: 10.4062/biomolther.2016.207
Recent reports claimed that glucosylsphingosine (GS) is highly accumulated and specifically evoking itch-scratch responses in the skins of atopic dermatitis (AD) patients. However, it was unclear how GS can trigger...
LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21

Zhou X, Yuan P, Liu Q, Liu Z

  • Biomol Ther.
  • 2017 Sep;25(5):490-496.
  • doi: 10.4062/biomolther.2016.162
Imatinib resistance has become a major clinical problem for chronic myeloid leukemia. The aim of the present study was to investigate the involvement of MEG3, a lncRNA, in imatinib resistance...
Regulation of Pharmacogene Expression by microRNA in The Cancer Genome Atlas (TCGA) Research Network

Han N, Song YK, Burckart G, Ji E, Kim IW, Oh JM

  • Biomol Ther.
  • 2017 Sep;25(5):482-489.
  • doi: 10.4062/biomolther.2017.122
Individual differences in drug responses are associated with genetic and epigenetic variability of pharmacogene expression. We aimed to identify the relevant miRNAs which regulate pharmacogenes associated with drug responses. The...
Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases

Xiao X, Liu HX, Shen K, Cao W, Li XQ

  • Biomol Ther.
  • 2017 Sep;25(5):471-481.
  • doi: 10.4062/biomolther.2016.096
The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca2+ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4,...
New Anticoagulants for the Prevention and Treatment of Venous Thromboembolism

Kim JH, Lim KM, Gwak HS

  • Biomol Ther.
  • 2017 Sep;25(5):461-470.
  • doi: 10.4062/biomolther.2016.271
Anticoagulant drugs, like vitamin K antagonists and heparin, have been the mainstay for the treatment and prevention of venous thromboembolic disease for many years. Although effective if appropriately used, traditional...

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