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Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells

Park GH, Song HM, Jeong JB

  • Biomol Ther.
  • 2017 May;25(3):337-343.
  • doi: 10.4062/biomolther.2016.114
Kahweol as a coffee-specific diterpene has been reported to induce apoptosis in human cancer cells. Although some molecular targets for kahweol-mediated apoptosis have been elucidated, the further mechanism for apoptotic...
Capsanthin Inhibits both Adipogenesis in 3T3-L1 Preadipocytes and Weight Gain in High-Fat Diet-Induced Obese Mice

Jo SJ, Kim JW, Choi HO, Kim JH, Kim HJ, Woo SH, Han BH

  • Biomol Ther.
  • 2017 May;25(3):329-336.
  • doi: 10.4062/biomolther.2017.048
Adipogenesis in murine preadipocyte 3T3L-1 has been used as a model system to study anti-obese bioactive molecules. During adipogenesis in 3T3-L1 preadipocytes, we found that capsanthin inhibited adipogenesis (ICâ‚…â‚€; 2.5...
Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells

Ye DJ, Kwon YJ, Shin S, Baek HS, Shin DW, Chun YJ

  • Biomol Ther.
  • 2017 May;25(3):321-328.
  • doi: 10.4062/biomolther.2016.155
Steroid sulfatase (STS) is an enzyme responsible for the hydrolysis of aryl and alkyl sulfates. STS plays a pivotal role in the regulation of estrogens and androgens that promote the...
Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells

Yao CW, Kang KA, Piao MJ, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Na SY, Jeong SU, Boo SJ, Hyun JW

  • Biomol Ther.
  • 2017 May;25(3):315-320.
  • doi: 10.4062/biomolther.2016.069
We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5-FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and...
A Novel Urotensin II Receptor Antagonist, KR-36996 Inhibits Smooth Muscle Proliferation through ERK/ROS Pathway

Kim TH, Lee DG, Kim YA, Lee BH, Yi KY, Jung YS

  • Biomol Ther.
  • 2017 May;25(3):308-314.
  • doi: 10.4062/biomolther.2016.219
Urotensin II (UII) is a mitogenic and hypertrophic agent that can induce the proliferation of vascular cells. UII inhibition has been considered as beneficial strategy for atherosclerosis and restenosis. However,...
Establishment of Immortalized Primary Human Foreskin Keratinocytes and Their Application to Toxicity Assessment and Three Dimensional Skin Culture Construction

Choi M, Park M, Lee S, Lee JW, Cho MC, Noh M, Lee C

  • Biomol Ther.
  • 2017 May;25(3):296-307.
  • doi: 10.4062/biomolther.2017.043
In spite of frequent usage of primary human foreskin keratinocytes (HFKs) in the study of skin biology, senescence-induced blockage of in vitro proliferation has been a big hurdle for their...
Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes

Han KM, Ahn SY, Seo H, Yun J, Cha HJ, Shin JS, Kim YH, Kim H, Park HK, Lee YM

  • Biomol Ther.
  • 2017 May;25(3):288-295.
  • doi: 10.4062/biomolther.2016.153
The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and...
Cinnamaldehyde Derivatives Inhibit Coxsackievirus B3-Induced Viral Myocarditis

Li XQ, Liu XX, Wang XY, Xie YH, Yang Q, Liu XX, Ding YY, Cao W, Wang SW

  • Biomol Ther.
  • 2017 May;25(3):279-287.
  • doi: 10.4062/biomolther.2016.070
The chemical property of cinnamaldehyde is unstable in vivo, although early experiments have shown its obvious therapeutic effects on viral myocarditis (VMC). To overcome this problem, we used cinnamaldehyde as...
Protective Role of Fucoidan in Cerebral Ischemia-Reperfusion Injury through Inhibition of MAPK Signaling Pathway

Che N, Ma Y, Xin Y

  • Biomol Ther.
  • 2017 May;25(3):272-278.
  • doi: 10.4062/biomolther.2016.098
Fucoidan has been reported to exhibit various beneficial activities ranging from to antivirus and anticancer properties. However, little information is available about the effects of fucoidan on cerebral ischemia-reperfusion injury...
Synthetic Cannabinoid-Induced Immunosuppression Augments Cerebellar Dysfunction in Tetanus-Toxin Treated Mice

Yun J, Gu SM, Lee TH, Song YJ, Seong S, Kim YH, Cha HJ, Han KM, Shin J, Oh H, Jung K, Ahn C, Park HK, Kim HS

  • Biomol Ther.
  • 2017 May;25(3):266-271.
  • doi: 10.4062/biomolther.2016.116
Synthetic cannabinoids are one of most abused new psychoactive substances. The recreational use of abused drug has aroused serious concerns about the consequences of these drugs on infection. However, the...
Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Chung E, Yoon TG, Kim S, Kang M, Kim HJ, Son Y

  • Biomol Ther.
  • 2017 May;25(3):259-265.
  • doi: 10.4062/biomolther.2016.137
This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI)...
Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice

Jeon SJ, Kim B, Ryu B, Kim E, Lee S, Jang DS, Ryu JH

  • Biomol Ther.
  • 2017 May;25(3):249-258.
  • doi: 10.4062/biomolther.2016.058
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time...
Molecular Signature That Determines the Acute Tolerance of G Protein-Coupled Receptors

Min C, Zhang X, Zheng M, Sun N, Acharya S, Zhang X, Kim KM

  • Biomol Ther.
  • 2017 May;25(3):239-248.
  • doi: 10.4062/biomolther.2016.193
Desensitization and acute tolerance are terms used to describe the attenuation of receptor responsiveness by prolonged or intermittent exposure to an agonist. Unlike desensitization of G protein-coupled receptors (GPCRs), which...
Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders

Jeon SJ, Ryu JH, Bahn GH

  • Biomol Ther.
  • 2017 May;25(3):231-238.
  • doi: 10.4062/biomolther.2016.042
Myelin is a specialized structure of the nervous system that both enhances electrical conductance and insulates neurons from external risk factors. In the central nervous system, polarized oligodendrocytes form myelin...
Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs

Shin EK, Park H, Noh JY, Lim KM, Chung JH

  • Biomol Ther.
  • 2017 May;25(3):223-230.
  • doi: 10.4062/biomolther.2016.138
Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or...

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