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Absorption Study of Genistein Using Solid Lipid Microparticles and Nanoparticles: Control of Oral Bioavailability by Particle Sizes

Kim JT, Barua S, Kim H, Hong SC, Yoo SY, Jeon H, Cho Y, Gil S, Oh K, Lee J

  • Biomol Ther.
  • 2017 Jul;25(4):452-459.
  • doi: 10.4062/biomolther.2017.095
In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were...
Imperatorin is Transported through Blood-Brain Barrier by Carrier-Mediated Transporters

Tun T, Kang YS

  • Biomol Ther.
  • 2017 Jul;25(4):441-451.
  • doi: 10.4062/biomolther.2017.082
Imperatorin, a major bioactive furanocoumarin with multifunctions, can be used for treating neurodegenerative diseases. In this study, we investigated the characteristics of imperatorin transport in the brain. Experiments of the...
Effect of Enhancers on in vitro and in vivo Skin Permeation and Deposition of S-Methyl-(L)-Methionine

Kim KT, Kim JS, Kim MH, Park JH, Lee JY, Lee W, Min KK, Song MG, Choi CY, Kim WS, Oh HK, Kim DD

  • Biomol Ther.
  • 2017 Jul;25(4):434-440.
  • doi: 10.4062/biomolther.2016.254
S-methyl-(L)-methionine (SMM), also known as vitamin U, is commercially available as skin care cosmetic products for its wound healing and photoprotective effects. However, the low skin permeation expected of SMM...
Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes

Hewage SR, Piao MJ, Kang KA, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Moon YJ, Shin DO, Hyun JW

  • Biomol Ther.
  • 2017 Jul;25(4):427-433.
  • doi: 10.4062/biomolther.2016.112
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved...
4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

Kim SC, Kang JI, Hyun JW, Kang JH, Koh YS, Kim YH, Kim KH, Ko JH, Yoo ES, Kang HK

  • Biomol Ther.
  • 2017 Jul;25(4):417-426.
  • doi: 10.4062/biomolther.2016.003
4-O-methylhonokiol, a neolignan compound from Magnolia Officinalis, has been reported to have various biological activities including hair growth promoting effect. However, although transforming growth factor-β (TGF-β) signal pathway has an...
Improved Antitumor Efficacy of Hyaluronic Acid-Complexed Paclitaxel Nanoemulsions in Treating Non-Small Cell Lung Cancer

Kim JE, Park YJ

  • Biomol Ther.
  • 2017 Jul;25(4):411-416.
  • doi: 10.4062/biomolther.2016.261
Paclitaxel (PTX) is a effectively chemotherapeutic agent which is extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it is a practically insoluble drug with...
A Benzylideneacetophenone Derivative Induces Apoptosis of Radiation-Resistant Human Breast Cancer Cells via Oxidative Stress

Park JE, Piao MJ, Kang KA, Shilnikova K, Hyun YJ, Oh SK, Jeong YJ, Chae S, Hyun JW

  • Biomol Ther.
  • 2017 Jul;25(4):404-410.
  • doi: 10.4062/biomolther.2017.010
Benzylideneacetophenone derivative (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one (JC3) elicited cytotoxic effects on MDA-MB 231 human breast cancer cells-radiation resistant cells (MDA-MB 231-RR), in a dose-dependent manner, with an IC₅₀ value of 6 μM...
PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination

Jin M, Park SJ, Kim SW, Kim HR, Hyun JW, Lee JH

  • Biomol Ther.
  • 2017 Jul;25(4):396-403.
  • doi: 10.4062/biomolther.2017.086
Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to severe genotoxic stress, p53 protein levels are markedly increased and apoptotic...
Sedative Effect of Sophora flavescens and Matrine

Lee HJ, Lee SY, Jang D, Chung SY, Shim I

  • Biomol Ther.
  • 2017 Jul;25(4):390-395.
  • doi: 10.4062/biomolther.2016.156
The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The...
Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response

Wang L, Liu H, Zhang L, Wang G, Zhang M, Yu Y

  • Biomol Ther.
  • 2017 Jul;25(4):383-389.
  • doi: 10.4062/biomolther.2015.180
Dexmedetomidine is an α2-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action...
Sex Differences in Autism-Like Behavioral Phenotypes and Postsynaptic Receptors Expression in the Prefrontal Cortex of TERT Transgenic Mice

Kim KC, Cho KS, Yang SM, Gonzales E, Valencia S, Eun PH, Choi CS, Mabunga DF, Kim JW, Noh JK, Kim HJ, Jeon SJ, Han SH, Bahn GH, Shin CY

  • Biomol Ther.
  • 2017 Jul;25(4):374-382.
  • doi: 10.4062/biomolther.2016.242
Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female...
Circulating Plasma and Exosomal microRNAs as Indicators of Drug-Induced Organ Injury in Rodent Models

Cho YE, Kim SH, Lee BH, Baek MC

  • Biomol Ther.
  • 2017 Jul;25(4):367-373.
  • doi: 10.4062/biomolther.2016.174
This study was performed to evaluate whether microRNAs (miRNAs) in circulating exosomes may serve as biomarkers of drug-induced liver, kidney, or muscle-injury. Quantitative PCR analyses were performed to measure the...
Comparison of Reprogramming Methods for Generation of Induced-Oligodendrocyte Precursor Cells

Lee EH, Park CH

  • Biomol Ther.
  • 2017 Jul;25(4):362-366.
  • doi: 10.4062/biomolther.2017.066
Direct conversion by trans-differentiation is of growing interest in cell therapy for incurable diseases. The efficiency of cell reprogramming and functionality of converted cells are important considerations in cell transplantation...
Role of TAZ in Lysophosphatidic Acid-Induced Migration and Proliferation of Human Adipose-Derived Mesenchymal Stem Cells

Mo WM, Kwon YW, Jang IH, Choi EJ, Kwon SM, Kim JH

  • Biomol Ther.
  • 2017 Jul;25(4):354-361.
  • doi: 10.4062/biomolther.2016.263
Transcriptional co-activator with a PDZ-binding motif (TAZ) is an important factor in lysophosphatidic acid (LPA)-induced promotion of migration and proliferation of human mesenchymal stem cells (MSCs). The expression of TAZ...
Production of Recombinant Anti-Cancer Vaccines in Plants

Lee JH, Ko K

  • Biomol Ther.
  • 2017 Jul;25(4):345-353.
  • doi: 10.4062/biomolther.2016.126
Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used...

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