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Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery

Park SJ, Im DS

  • Biomol Ther.
  • 2017 Jan;25(1):80-90.
  • doi: 10.4062/biomolther.2016.160
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G...
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection

Lee S, Chung YH, Lee C

  • Biomol Ther.
  • 2017 Jan;25(1):69-79.
  • doi: 10.4062/biomolther.2016.208
Viruses continue to evolve a new strategy to take advantage of every aspect of host cells in order to maximize their survival. Due to their central roles in transducing a...
Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors

Furlong M, Seong JY

  • Biomol Ther.
  • 2017 Jan;25(1):57-68.
  • doi: 10.4062/biomolther.2016.199
Seven transmembrane receptors (7TMRs), also known as G protein-coupled receptors, are popular targets of drug development, particularly 7TMR systems that are activated by peptide ligands. Although many pharmaceutical drugs have...
β-Adrenergic Receptor and Insulin Resistance in the Heart

Mangmool S, Denkaew T, Parichatikanond W, Kurose H

  • Biomol Ther.
  • 2017 Jan;25(1):44-56.
  • doi: 10.4062/biomolther.2016.128
Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and...
Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis

Zhang X, Kim KM

  • Biomol Ther.
  • 2017 Jan;25(1):26-43.
  • doi: 10.4062/biomolther.2016.186
Endocytosis is a process by which cells absorb extracellular materials via the inward budding of vesicles formed from the plasma membrane. Receptor-mediated endocytosis is a highly selective process where receptors...
Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology

Bologna Z, Teoh JP, Bayoumi AS, Tang Y, Kim IM

  • Biomol Ther.
  • 2017 Jan;25(1):12-25.
  • doi: 10.4062/biomolther.2016.165
G protein-coupled receptors (GPCRs) are a family of cell-surface proteins that play critical roles in regulating a variety of pathophysiological processes and thus are targeted by almost a third of...
Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation

Duc NM, Kim HR, Chung KY

  • Biomol Ther.
  • 2017 Jan;25(1):4-11.
  • doi: 10.4062/biomolther.2016.169
Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have...
Conceptual Progress for the Improvements in the Selectivity and Efficacy of G Protein-Coupled Receptor Therapeutics: An Overview

Kim KM

  • Biomol Ther.
  • 2017 Jan;25(1):1-3.
  • doi: 10.4062/biomolther.2016.262
No abstract available.

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