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Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves

Kim JH, Lee J, Kang S, Moon H, Chung KH, Kim KR

  • Biomol Ther.
  • 2016 Nov;24(6):659-664.
  • doi: 10.4062/biomolther.2016.021
Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities....
Protective Effects of Ecklonia stolonifera Extract on Ethanol-Induced Fatty Liver in Rats

Bang CY, Byun JH, Choi HK, Choi JS, Choung SY

  • Biomol Ther.
  • 2016 Nov;24(6):650-658.
  • doi: 10.4062/biomolther.2016.176
Chronic alcohol consumption causes alcoholic liver disease, which is associated with the initiation of dysregulated lipid metabolism. Recent evidences suggest that dysregulated cholesterol metabolism plays an important role in the...
DW2007 Ameliorates Colitis and Rheumatoid Arthritis in Mice by Correcting Th17/Treg Imbalance and Inhibiting NF-κB Activation

Lim SM, Lee SY, Jeong JJ, Choi HS, Chang HB, Kim DH

  • Biomol Ther.
  • 2016 Nov;24(6):638-649.
  • doi: 10.4062/biomolther.2016.018
In the previous study, the rhizome mixture of Anemarrhena asphodeloides and Coptis chinensis (DW2007), improved TNBS-, oxazolone-, or DSS-induced colitis in mice by regulating macrophage activation. Therefore, to understand the...
Anti-Inflammatory Properties of Flavone di-C-Glycosides as Active Principles of Camellia Mistletoe, Korthalsella japonica

Kim MK, Yun KJ, Lim DH, Kim J, Jang YP

  • Biomol Ther.
  • 2016 Nov;24(6):630-637.
  • doi: 10.4062/biomolther.2016.019
The chemical components and biological activity of Camellia mistletoe, Korthalsella japonica (Loranthaceae) are relatively unknown compared to other mistletoe species. Therefore, we investigated the phytochemical properties and biological activity of...
The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells

Kim EJ, Kang JI, Tung NH, Kim YH, Hyun JW, Koh YS, Chang WY, Yoo ES, Kang HK

  • Biomol Ther.
  • 2016 Nov;24(6):623-629.
  • doi: 10.4062/biomolther.2016.023
(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide (LS-1), a marine cembrenolide diterpene, has anticancer activity against colon cancer cells such as HT-29, SNU-C5/5-FU (fluorouracil-resistant SNU-C5) and SNU-C5. However, the action mechanism of LS-1 on SNU-C5 human...
Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress

Oh MC, Piao MJ, Fernando P, Han X, Hewage SR, Park JE, Ko MS, Jung U, Kim IG, Hyun JW

  • Biomol Ther.
  • 2016 Nov;24(6):616-622.
  • doi: 10.4062/biomolther.2016.022
Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated apoptosis induced...
Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells

Park JY, Lim MS, Kim SI, Lee HJ, Kim SS, Kwon YS, Chun W

  • Biomol Ther.
  • 2016 Nov;24(6):610-615.
  • doi: 10.4062/biomolther.2016.026
Quercetin, a flavonol, has been reported to exhibit a wide range of biological properties including anti-oxidant and anti-inflammatory activities. However, pharmacological properties of quercetin-3-O-β-D-glucuronide (QG), a glycoside derivative of quercetin,...
Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin

Lee J, Kang JS, Choi BY, Keum YS

  • Biomol Ther.
  • 2016 Nov;24(6):604-609.
  • doi: 10.4062/biomolther.2016.028
5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding...
Pyrrole-Derivative of Chalcone, (E)-3-Phenyl-1-(2-Pyrrolyl)-2-Propenone, Inhibits Inflammatory Responses via Inhibition of Src, Syk, and TAK1 Kinase Activities

Yang S, Kim Y, Jeong D, Kim JH, Kim S, Son YJ, Yoo BC, Jeong EJ, Kim TW, Han Lee IS, Cho JY

  • Biomol Ther.
  • 2016 Nov;24(6):595-603.
  • doi: 10.4062/biomolther.2016.027
(E)-3-Phenyl-1-(2-pyrrolyl)-2-propenone (PPP) is a pyrrole derivative of chalcone, in which the B-ring of chalcone linked to β-carbon is replaced by pyrrole group. While pyrrole has been studied for possible Src...
Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells

Ramalingam M, Kwon YD, Kim SJ

  • Biomol Ther.
  • 2016 Nov;24(6):589-594.
  • doi: 10.4062/biomolther.2016.030
Insulin is a peptide hormone of the endocrine pancreas and exerts a wide variety of physiological actions in insulin sensitive tissues, such as regulation of glucose homeostasis, cell growth, differentiation,...
Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes

Jeong YH, Park JS, Kim DH, Kim HS

  • Biomol Ther.
  • 2016 Nov;24(6):581-588.
  • doi: 10.4062/biomolther.2016.141
Lonchocarpine is a phenylpropanoid compound isolated from Abrus precatorius that has anti-bacterial, anti-inflammatory, antiproliferative, and antiepileptic activities. In the present study, we investigated the antioxidant effects of lonchocarpine in brain...
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

Kim YE, Choi HC, Lee IC, Yuk DY, Lee H, Choi BY

  • Biomol Ther.
  • 2016 Nov;24(6):572-580.
  • doi: 10.4062/biomolther.2016.183
3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle...
Marine-Derived Pharmaceuticals – Challenges and Opportunities

Lindequist U

  • Biomol Ther.
  • 2016 Nov;24(6):561-571.
  • doi: 10.4062/biomolther.2016.181
Marine biosphere is the largest one of the earth and harbors an enormous number of different organisms. Living conditions differ fundamentally from those in terrestrial environment. The production of specific...

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