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Effects of Triclosan on Neural Stem Cell Viability and Survival

Park BK, Gonzales E, Yang SM, Bang M, Choi CS, Shin CY

  • Biomol Ther.
  • 2016 Jan;24(1):99-107.
  • doi: 10.4062/biomolther.2015.164
Triclosan is an antimicrobial or sanitizing agent used in personal care and household products such as toothpaste, soaps, mouthwashes and kitchen utensils. There are increasing evidence of the potentially harmful...
Effects of Bisphosphonates on Glucose Transport in a Conditionally Immortalized Rat Retinal Capillary Endothelial Cell Line (TR-iBRB Cells)

Lee NY, Park HJ, Kang YS

  • Biomol Ther.
  • 2016 Jan;24(1):94-98.
  • doi: 10.4062/biomolther.2015.183
The objective of the present study was to elucidate the effect of bisphosphonates, anti-osteoporosis agents, on glucose uptake in retinal capillary endothelial cells under normal and high glucose conditions. The...
Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin

Lee TH, Kang JH, Seo JO, Baek SH, Moh SH, Chae JK, Park YU, Ko YT, Kim SY

  • Biomol Ther.
  • 2016 Jan;24(1):85-93.
  • doi: 10.4062/biomolther.2015.165
We already reported that genetically engineered resveratrol-enriched rice (RR) showed to down-regulate skin melanogenesis. To be developed to increase the bioactivity of RR using calli from plants, RR was adopted...
Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells

Fernando P, Piao MJ, Kang KA, Ryu YS, Hewage SR, Chae SW, Hyun JW

  • Biomol Ther.
  • 2016 Jan;24(1):75-84.
  • doi: 10.4062/biomolther.2015.069
This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging...
Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents

Lee JH, Sun YN, Kim YH, Lee SK, Kim HP

  • Biomol Ther.
  • 2016 Jan;24(1):67-74.
  • doi: 10.4062/biomolther.2015.070
In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as...
Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells

Lee HM, Moon A

  • Biomol Ther.
  • 2016 Jan;24(1):62-66.
  • doi: 10.4062/biomolther.2015.172
Amygdalin, D-mandelonitrile-beta-D-glucoside-6-beta-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor...
Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility

Je HD, Sohn UD, La HO

  • Biomol Ther.
  • 2016 Jan;24(1):57-61.
  • doi: 10.4062/biomolther.2015.104
Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of...
Aloe-Emodin Protects RIN-5F (Pancreatic beta-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3

Alshatwi A, Subash-Babu P

  • Biomol Ther.
  • 2016 Jan;24(1):49-56.
  • doi: 10.4062/biomolther.2015.056
To determine the protective effect of aloe-emodin (AE) from high glucose induced toxicity in RIN-5F (pancreatic beta-cell) cell and restoration of its function was analyzed. RIN-5F cells have been cultured...
PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice

Ye N, Wang H, Hong J, Zhang T, Lin C, Meng C

  • Biomol Ther.
  • 2016 Jan;24(1):40-48.
  • doi: 10.4062/biomolther.2015.077
The pregnane X receptor (PXR), a liver and intestine specific receptor,, has been reported to be related with the repression of inflammation as well as activation of cytochromosome P450 3A...
Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling

Jung JS, Lee SY, Kim DH, Kim HS

  • Biomol Ther.
  • 2016 Jan;24(1):33-39.
  • doi: 10.4062/biomolther.2015.129
Oxidative stress activates several intracellular signaling cascades that may have deleterious effects on neuronal cell survival. Thus, controlling oxidative stress has been suggested as an important strategy for prevention and/or...
Lobaric Acid Inhibits VCAM-1 Expression in TNF-alpha-Stimulated Vascular Smooth Muscle Cells via Modulation of NF-kappaB and MAPK Signaling Pathways

Kwon IS, Yim JH, Lee HK, Pyo S

  • Biomol Ther.
  • 2016 Jan;24(1):25-32.
  • doi: 10.4062/biomolther.2015.084
Lichens have been known to possess multiple biological activities, including anti-proliferative and anti-inflammatory activities. Vascular cell adhesion molecule-1 (VCAM-1) may play a role in the development of atherosclerosis. Hence, VCAM-1...
Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis

Zhang J, Gao C, Meng M, Tang H

  • Biomol Ther.
  • 2016 Jan;24(1):19-24.
  • doi: 10.4062/biomolther.2015.066
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The exploration of new biomarkers with high sensitivity and specificity for early diagnosis of AMI therefore becomes...
NDRG2 Expression Decreases Tumor-Induced Osteoclast Differentiation by Down-regulating ICAM1 in Breast Cancer Cells

Kim B, Nam S, Lim JH, Lim JS

  • Biomol Ther.
  • 2016 Jan;24(1):9-18.
  • doi: 10.4062/biomolther.2015.105
Bone matrix is properly maintained by osteoclasts and osteoblasts. In the tumor microenvironment, osteoclasts are increasingly differentiated by the various ligands and cytokines secreted from the metastasized cancer cells at...
Alpha-Ketoglutarate: Physiological Functions and Applications

Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D

  • Biomol Ther.
  • 2016 Jan;24(1):1-8.
  • doi: 10.4062/biomolther.2015.078
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source...

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