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Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay

Kim YH, Bae YJ, Kim HS, Cha HJ, Yun JS, Shin JS, Seong WK, Lee YM, Han KM

  • Biomol Ther.
  • 2015 Sep;23(5):486-492.
  • doi: 10.4062/biomolther.2015.041
Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA...
Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms

Joung HY, Kang YM, Lee BJ, Chung SY, Kim KS, Shim I

  • Biomol Ther.
  • 2015 Sep;23(5):479-485.
  • doi: 10.4062/biomolther.2014.122
This study was performed to investigate the sedative-hypnotic activity of gamma-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis...
Anti-Oxidative Effect of Myrtenal in Prevention and Treatment of Colon Cancer Induced by 1, 2-Dimethyl Hydrazine (DMH) in Experimental Animals

Lokeshkumar B, Sathishkumar V, Nandakumar N, Rengarajan T, Madankumar A, Balasubramanian MP

  • Biomol Ther.
  • 2015 Sep;23(5):471-478.
  • doi: 10.4062/biomolther.2015.039
Colon cancer is considered as the precarious forms of cancer in many developed countries, with few to no symptoms; the tumor is often diagnosed in the later stages of cancer....
Antiviral Activity of Chrysin Derivatives against Coxsackievirus B3 in vitro and in vivo

Song JH, Kwon BE, Jang H, Kang H, Cho S, Park K, Ko HJ, Kim H

  • Biomol Ther.
  • 2015 Sep;23(5):465-470.
  • doi: 10.4062/biomolther.2015.095
Chrysin is a 5,7-dihydroxyflavone and was recently shown to potently inhibit enterovirus 71 (EV71) by suppressing viral 3C protease (3Cpro) activity. In the current study, we investigated whether chrysin also...
Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H+/K+-ATPase

Hwang IY, Jeong CS

  • Biomol Ther.
  • 2015 Sep;23(5):458-464.
  • doi: 10.4062/biomolther.2015.052
Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer....
A Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis

Park D, Jo IG, Jang JY, Kwak TH, Yoo SK, Jeon JH, Choi EK, Joo SS, Kim O, Kim YB

  • Biomol Ther.
  • 2015 Sep;23(5):449-457.
  • doi: 10.4062/biomolther.2015.034
The present study was aimed to investigate the effects of MB12662, a synthetic dunnione compound, on cisplatin-induced vomiting reflexes and intestinal, renal, immune system, and hematopoietic toxicities in ferrets and...
Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo

Park JS, Lee HJ, Lee DY, Jo HS, Jeong JH, Kim DH, Nam DC, Lee CJ, Hwang SC

  • Biomol Ther.
  • 2015 Sep;23(5):442-448.
  • doi: 10.4062/biomolther.2015.045
We evaluated the chondroprotective effects of wogonin by investigating its effects on the gene expression and production of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as...
A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1

De U, Kundu S, Patra N, Ahn MY, Ahn JH, Son JY, Yoon JH, Moon HR, Lee BM, Kim HS

  • Biomol Ther.
  • 2015 Sep;23(5):434-441.
  • doi: 10.4062/biomolther.2015.026
Histone deacetylase (HDAC) inhibitors are considered novel agents for cancer chemotherapy. We previously investigated MHY219, a new HDAC inhibitor, and its potent anticancer activity in human prostate cancer cells. In...
Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-kappaB Activity

Cho SC, Choi BY

  • Biomol Ther.
  • 2015 Sep;23(5):428-433.
  • doi: 10.4062/biomolther.2015.102
Acetylshikonin, a natural naphthoquinone derivative compound, has been used for treatment of inflammation and cancer. In the present study, we have investigated whether acetylshikonin could regulate the NF-kappaB signaling pathway,...
Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells

Jeong KT, Lee E, Park NY, Kim SG, Park HH, Lee J, Lee YJ, Lee E

  • Biomol Ther.
  • 2015 Sep;23(5):421-427.
  • doi: 10.4062/biomolther.2015.023
Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse...
Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk

Kim JH, Kim MY, Kim JH, Cho JY

  • Biomol Ther.
  • 2015 Sep;23(5):414-420.
  • doi: 10.4062/biomolther.2015.036
Flavonoids, such as fisetin (3,7,3',4'-tetrahydroxyflavone), are plant secondary metabolites. It has been reported that fisetin is able to perform numerous pharmacological roles including anti-inflammatory, anti-microbial, and anti-cancer activities; however, the...
Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells

Jang YJ, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Hong S, Chang M, Kim DK

  • Biomol Ther.
  • 2015 Sep;23(5):407-413.
  • doi: 10.4062/biomolther.2015.075
Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has...
Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid

Peng JF, Liu L, Guo CX, Liu SK, Chen XP, Huang LH, Xiang H, Huang ZJ, Yuan H, Yang GP

  • Biomol Ther.
  • 2015 Sep;23(5):400-406.
  • doi: 10.4062/biomolther.2015.010
MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate...
Immortalization of Primary Keratinocytes and Its Application to Skin Research

Choi M, Lee C

  • Biomol Ther.
  • 2015 Sep;23(5):391-399.
  • doi: 10.4062/biomolther.2015.038
As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for...

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