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Preclinical Pharmacokinetic Evaluation of beta-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats

Kim I, Kim H, Ro J, Jo K, Karki S, Khadka P, Yun G, Lee J

  • Biomol Ther.
  • 2015 May;23(3):296-300.
  • doi: 10.4062/biomolther.2015.029
beta-Lapachone has drawn increasing attention as an anti-inflammatory and anti-cancer drug. However, its oral bioavailability has not been yet assessed, which might be useful to develop efficient dosage forms possibly...
Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila

Ghimire S, Kim MS

  • Biomol Ther.
  • 2015 May;23(3):290-295.
  • doi: 10.4062/biomolther.2014.147
Aging is defined as a collective process that alters organism's functional capacity and appearance over the course of life. Apart from an increase in susceptibility to many diseases, aging affects...
Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities

Roh HJ, Noh HJ, Na CS, Kim CS, Kim KH, Hong CY, Lee KR

  • Biomol Ther.
  • 2015 May;23(3):283-289.
  • doi: 10.4062/biomolther.2014.140
The half-dried leaves of Stewartia. pseudocamellia were extracted with hot water (SPE) and partitioned with n-hexane (SPEH), dichloromethane (SPED), and ethyl acetate (SPEE) successively. SPE and SPEE showed significant inhibitory...
Neuroprotective and Antioxidant Effects of Novel Benzofuran-2-Carboxamide Derivatives

Cho J, Park C, Lee Y, Kim S, Bose S, Choi M, Kumar AS, Jung JK, Lee H

  • Biomol Ther.
  • 2015 May;23(3):275-282.
  • doi: 10.4062/biomolther.2015.030
In the present study, we synthesized a series of novel 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives in moderate to good yields and evaluated their neuroprotective and antioxidant activities using primary cultured rat cortical...
Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice

Mabunga DF, Gonzales E, Kim HJ, Choung SY

  • Biomol Ther.
  • 2015 May;23(3):268-274.
  • doi: 10.4062/biomolther.2015.022
gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian central nervous system, is involved in sleep physiology. Caffeine is widely used psychoactive substance known to induce wakefulness and insomnia...
Effect of Pioglitazone on Excitotoxic Neuronal Damage in the Mouse Hippocampus

Lee CH, Yi MH, Chae DJ, Zhang E, Oh SH, Kim DW

  • Biomol Ther.
  • 2015 May;23(3):261-267.
  • doi: 10.4062/biomolther.2014.146
Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor gamma agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the...
Repeated Neonatal Propofol Administration Induces Sex-Dependent Long-Term Impairments on Spatial and Recognition Memory in Rats

Gonzales E, Yang SM, Choi CS, Mabunga DF, Kim HJ, Cheong JH, Ryu JH, Koo BN, Shin CY

  • Biomol Ther.
  • 2015 May;23(3):251-260.
  • doi: 10.4062/biomolther.2014.120
Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment...
Protective Effects of Silibinin and Its Possible Mechanism of Action in Mice Exposed to Chronic Unpredictable Mild Stress

Yan WJ, Tan YC, Xu JC, Tang XP, Zhang C, Zhang PB, Ren ZQ

  • Biomol Ther.
  • 2015 May;23(3):245-250.
  • doi: 10.4062/biomolther.2014.138
Silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, has recently been identified as having anti-hepatotoxic and anticancer properties. In this paper, we investigated the effects...
Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-gamma Stimulated HaCaT Human Keratinocytes

Kang NJ, Koo DH, Kang GJ, Han SC, Lee BW, Koh YS, Hyun JW, Lee NH, Ko MH, Kang HK, Yoo ES

  • Biomol Ther.
  • 2015 May;23(3):238-244.
  • doi: 10.4062/biomolther.2014.141
Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22...
The Inhibitory Effect of Shikonin on the Agonist-Induced Regulation of Vascular Contractility

Je HD, Kim HD, La HO

  • Biomol Ther.
  • 2015 May;23(3):233-237.
  • doi: 10.4062/biomolther.2014.148
Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin...
Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling

Han YS, Lee JH, Lee SH

  • Biomol Ther.
  • 2015 May;23(3):225-232.
  • doi: 10.4062/biomolther.2014.136
We identified a novel Akt signaling mechanism that mediates fucoidan-induced suppression of human colon cancer cell (HT29) proliferation and anticancer effects. Fucoidan treatment significantly inhibited growth, induced G1-phase-associated upregulation of...
A Cannabinoid Receptor Agonist N-Arachidonoyl Dopamine Inhibits Adipocyte Differentiation in Human Mesenchymal Stem Cells

Ahn S, Yi S, Seo WJ, Lee MJ, Song YK, Baek SY, Yu J, Hong SH, Lee J, Shin DW, Jeong LS, Noh M

  • Biomol Ther.
  • 2015 May;23(3):218-224.
  • doi: 10.4062/biomolther.2014.137
Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and peroxisome proliferator-activated receptor gamma (PPARgamma). The stimuli to...
Role of Micronutrients in Skin Health and Function

Park K

  • Biomol Ther.
  • 2015 May;23(3):207-217.
  • doi: 10.4062/biomolther.2015.003
Skin is the first line of defense for protecting our bodies against external perturbations, including ultraviolet (UV) irradiation, mechanical/chemical stress, and bacterial infection. Nutrition is one of many factors required...

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