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13 results

Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-kappaB-signaling Pathway

Kim B, Kim JE, Choi BK, Kim HS

  • Biomol Ther.
  • 2015 Jan;23(1):90-97.
  • doi: 10.4062/biomolther.2014.080
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant...
7alpha-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells

Seo HC, Kim SM, Eo SK, Rhim BY, Kim K

  • Biomol Ther.
  • 2015 Jan;23(1):84-89.
  • doi: 10.4062/biomolther.2014.067
We investigated the question of whether 7-oxygenated cholesterol derivatives could affect inflammatory and/or immune responses in atherosclerosis by examining their effects on expression of IL-23 in monocytic cells. 7alpha-Hydroxycholesterol (7alphaOHChol)...
Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans

Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK

  • Biomol Ther.
  • 2015 Jan;23(1):77-83.
  • doi: 10.4062/biomolther.2014.075
The seed of Vigna angularis has long been cultivated as a food or a folk medicine in East Asia. Genistein (4',5,7-trihydroxyisoflavone), a dietary phytoestrogen present in this plant, has been...
Ciglitazone, a Peroxisome Proliferator-Activated Receptor Gamma Ligand, Inhibits Proliferation and Differentiation of Th17 Cells

Kim DH, Ihn HJ, Moon C, Oh SS, Park S, Kim S, Lee KW, Kim KD

  • Biomol Ther.
  • 2015 Jan;23(1):71-76.
  • doi: 10.4062/biomolther.2014.042
Peroxisome proliferator-activated receptor gamma (PPARgamma) was identified as a cell-intrinsic regulator of Th17 cell differentiation. Th17 cells have been associated with several autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), inflammatory...
Effect of Cordycepin-Enriched WIB801C from Cordyceps militaris Suppressing Fibrinogen Binding to Glycoprotein IIb/IIIa

Lee DH, Kim HH, Lim DH, Kim JL, Park HJ

  • Biomol Ther.
  • 2015 Jan;23(1):60-70.
  • doi: 10.4062/biomolther.2014.086
In this study, we investigated the effects of cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha on collagen-stimulated platelet aggregation. CE-WIB801C dose dependently inhibited collagen-induced platelet aggregation, and had a...
Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury

Sohn YA, Hwang SA, Lee SY, Hwang IY, Kim SW, Kim SY, Moon A, Lee YS, Kim YH, Kang KJ, Jeong CS

  • Biomol Ther.
  • 2015 Jan;23(1):53-59.
  • doi: 10.4062/biomolther.2014.103
In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric...
Therapeutic Effects of S-Petasin on Disease Models of Asthma and Peritonitis

Lee KP, Kang S, Noh MS, Park SJ, Kim JM, Chung HY, Je NK, Lee YG, Choi YW, Im DS

  • Biomol Ther.
  • 2015 Jan;23(1):45-52.
  • doi: 10.4062/biomolther.2014.069
To explore the anti-allergic and anti-inflammatory effects of extracts of Petasites genus, we studied the effects of s-petasin, a major sesquiterpene from Petasites formosanus (a butterbur species) on asthma and...
Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-kappaB Signaling

Shao HJ, Lou Z, Jeong JB, Kim KJ, Lee J, Lee SH

  • Biomol Ther.
  • 2015 Jan;23(1):39-44.
  • doi: 10.4062/biomolther.2014.088
Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. Nuclear factor kappa B (NF-kappaB) is a sequence-specific transcription factor...
The Histone Deacetylase Inhibitor Trichostatin A Sensitizes Human Renal Carcinoma Cells to TRAIL-Induced Apoptosis through Down-Regulation of c-FLIP(L)

Han MH, Park C, Kwon TK, Kim GY, Kim WJ, Hong SH, Yoo YH, Choi YH

  • Biomol Ther.
  • 2015 Jan;23(1):31-38.
  • doi: 10.4062/biomolther.2014.092
Histone acetylation plays a critical role in the regulation of transcription by altering the structure of chromatin, and it may influence the resistance of some tumor cells to tumor necrosis...
Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells

Shim AR, Dong GZ, Lee HJ, Ryu JH

  • Biomol Ther.
  • 2015 Jan;23(1):26-30.
  • doi: 10.4062/biomolther.2014.095
Wnt/beta-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated beta-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the...
Thymosin Beta-4, Actin-Sequestering Protein Regulates Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Nitric Oxide Production in HeLa Cervical Cancer Cells

Ryu YK, Lee JW, Moon EY

  • Biomol Ther.
  • 2015 Jan;23(1):19-25.
  • doi: 10.4062/biomolther.2014.101
Vascular endothelial growth factor (VEGF) is an important regulator of neovascularization. Hypoxia inducible nitric oxide (NO) enhanced the expression of VEGF and thymosin beta-4 (Tbeta4), actin sequestering protein. Here, we...
Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition

Bae ON, Noh M, Chun YJ, Jeong TC

  • Biomol Ther.
  • 2015 Jan;23(1):12-18.
  • doi: 10.4062/biomolther.2014.102
Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in...
Promising Pharmacological Directions in the World of Lysophosphatidic Acid Signaling

Stoddard N, Chun J

  • Biomol Ther.
  • 2015 Jan;23(1):1-11.
  • doi: 10.4062/biomolther.2014.109
Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. These receptors initiate signaling cascades relevant to development, maintenance, and healing processes...

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