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16 results

Erratum to "Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells" [Biomol. Ther. 22 (2014) 355-362]

An D, Kim K, Kim J

  • Biomol Ther.
  • 2014 Sep;22(5):475-475.
  • doi: 10.4062/biomolther.2014.475
The authors request to correct the project number NRF-2013R1A1A1010734 from NRF-116436 on the 4th line of Acknowledgments section.
Erratum to "L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats" [Biomol. Ther. 22 (2014) 213-222]

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • Biomol Ther.
  • 2014 Sep;22(5):474-474.
  • doi: 10.4062/biomolther.2014.474
In the article, incorrect images were placed in Fig. 8.
Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment

Kim CY, Lee GY, Park GH, Lee J, Jang JH

  • Biomol Ther.
  • 2014 Sep;22(5):467-473.
  • doi: 10.4062/biomolther.2014.063
The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced...
Conditioned Place Preference and Self-Administration Induced by Nicotine in Adolescent and Adult Rats

Ahsan HM, de la Pena JBI, Botanas CJ, Kim HJ, Yu GY, Cheong JH

  • Biomol Ther.
  • 2014 Sep;22(5):460-466.
  • doi: 10.4062/biomolther.2014.056
Nicotine addiction is a worldwide problem. However, previous studies characterizing the rewarding and reinforcing effects of nicotine in animal models have reported inconsistent findings. It was observed that the addictive...
Strain Differences in the Chronic Mild Stress Animal Model of Depression and Anxiety in Mice

Jung YH, Hong SI, Ma SX, Hwang JY, Kim JS, Lee JH, Seo JY, Lee SY, Jang CG

  • Biomol Ther.
  • 2014 Sep;22(5):453-459.
  • doi: 10.4062/biomolther.2014.058
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms of human depression. In the present study, we used a...
Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice

Moon E, Lee SO, Kang TH, Kim HJ, Choi SZ, Son MW, Kim SY

  • Biomol Ther.
  • 2014 Sep;22(5):445-452.
  • doi: 10.4062/biomolther.2014.051
The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model....
The Leaves of Broussonetia kazinoki Siebold Inhibit Atopic Dermatitis-Like Response on Mite Allergen-Treated Nc/Nga Mice

Lee H, Ha H, Lee JK, Park SJ, Jeong SI, Shin HK

  • Biomol Ther.
  • 2014 Sep;22(5):438-444.
  • doi: 10.4062/biomolther.2014.023
Broussonetia kazinoki Siebold. (B. kazinoki) has long been used in the manufacture of paper in Asian countries. Although B. kazinoki leaves (BK) have been employed in dermatological therapy, use of...
Resveratrol-Enriched Rice Down-Regulates Melanin Synthesis in UVB-Induced Guinea Pigs Epidermal Skin Tissue

Lee TH, Seo JO, Do MH, Ji E, Baek SH, Kim SY

  • Biomol Ther.
  • 2014 Sep;22(5):431-437.
  • doi: 10.4062/biomolther.2014.098
Synthetic compounds that are used in the clinic to regulate skin hyperpigmentation, such as arbutin, hydroquinone, and kojic acid, are only moderately effective. But, their use is limited by side...
Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells

Lee MH, Kundu JK, Keum YS, Cho YY, Surh YJ, Choi BY

  • Biomol Ther.
  • 2014 Sep;22(5):426-430.
  • doi: 10.4062/biomolther.2014.061
Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional...
Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats

Kang JW, Lee SM

  • Biomol Ther.
  • 2014 Sep;22(5):420-425.
  • doi: 10.4062/biomolther.2014.066
Esophageal reflux of gastric contents causes esophageal mucosal damage and inflammation. Recent studies show that oxygen-derived free radicals mediate mucosal damage in reflux esophagitis (RE). Chlorogenic acid (CGA), an ester...
Comparison of the Effects of Matrix Metalloproteinase Inhibitors on TNF-alpha Release from Activated Microglia and TNF-alpha Converting Enzyme Activity

Lee EJ, Moon PG, Baek MC, Kim HS

  • Biomol Ther.
  • 2014 Sep;22(5):414-419.
  • doi: 10.4062/biomolther.2014.099
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that regulate cell-matrix composition and are also involved in processing various bioactive molecules such as cell-surface receptors, chemokines, and cytokines. Our group recently reported...
Effects of Atomoxetine on Hyper-Locomotive Activity of the Prenatally Valproate-Exposed Rat Offspring

Choi CS, Hong M, Kim KC, Kim JW, Yang SM, Seung H, Ko MJ, Choi DH, You JS, Shin CY, Bahn GH

  • Biomol Ther.
  • 2014 Sep;22(5):406-413.
  • doi: 10.4062/biomolther.2014.027
A substantial proportion of patients with autism spectrum disorder (ASD) display hyperactivity as a comorbid symptom. Exposure to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes as well...
HD047703, a New Promising Anti-Diabetic Drug Candidate: In Vivo Preclinical Studies

Kim S, Kim DH, Kim YS, Ha TY, Yang J, Park SH, Jeong KW, Rhee JK

  • Biomol Ther.
  • 2014 Sep;22(5):400-405.
  • doi: 10.4062/biomolther.2014.035
G-protein coupled receptor 119 (GPR119) has emerged as a novel target for the treatment of type 2 diabetes mellitus. GPR119 is involved in glucose-stimulated insulin secretion (GSIS) from the pancreatic...
TI-I-174, a Synthetic Chalcone Derivative, Suppresses Nitric Oxide Production in Murine Macrophages via Heme Oxygenase-1 Induction and Inhibition of AP-1

Kim MJ, Kadayat T, Kim DE, Lee ES, Park PH

  • Biomol Ther.
  • 2014 Sep;22(5):390-399.
  • doi: 10.4062/biomolther.2014.062
Chalcones (1,3-diaryl-2-propen-1-ones), a flavonoid subfamily, are widely known for their anti-inflammatory properties. Propenone moiety in chalcones is known to play an important role in generating biological responses by chalcones. In...
Regulatory Role of Autophagy in Globular Adiponectin-Induced Apoptosis in Cancer Cells

Nepal S, Park PH

  • Biomol Ther.
  • 2014 Sep;22(5):384-389.
  • doi: 10.4062/biomolther.2014.021
Adiponectin, an adipokine predominantly secreted from adipose tissue, exhibits diverse biological responses, including metabolism of glucose and lipid, and apoptosis in cancer cells. Recently, adiponectin has been shown to modulate...
Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification

Kobet RA, Pan X, Zhang B, Pak SC, Asch AS, Lee MH

  • Biomol Ther.
  • 2014 Sep;22(5):371-383.
  • doi: 10.4062/biomolther.2014.084
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional...

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